This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
FBXW7 Monoclonal Antibody (OTI6F5)
catalog :
MA5-26562
quantity :
100 uL
price :
US 504.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
OTI6F5

The same clone is also sold as:
reactivity :
human
application :
western blot, immunohistochemistry, immunohistochemistry - paraffin section
citations: 2
Reference
Meier Abt F, Kraemer D, Braun N, Reinehr M, Stutz Grunder E, Steindl K, et al. Further evidence that the neurodevelopmental gene FBXW7 predisposes to Wilms tumor. Am J Med Genet A. 2024;194:e63528 pubmed publisher
Mozūraitienė J, Gudleviciene Z, Vincerzevskiene I, Laurinaviciene A, Pamedys J. Expression levels of FBXW7 and MDM2 E3 ubiquitin ligases and their c-Myc and p53 substrates in patients with dysplastic nevi or melanoma. Oncol Lett. 2021;21:37 pubmed publisher
product information
Product Type :
Antibody
Product Name :
FBXW7 Monoclonal Antibody (OTI6F5)
Catalog # :
MA5-26562
Quantity :
100 uL
Price :
US 504.00
Clonality :
Monoclonal
Purity :
Affinity Chromatography
Host :
Mouse
Reactivity :
Human
Applications :
Immunohistochemistry (Paraffin): 1:150, Western Blot: 1:2,000
Species :
Human
Clone :
OTI6F5
Isotype :
IgG2a
Storage :
-20 C, Avoid Freeze/Thaw Cycles
Description :
F-Box and WD Repeat Domain Containing 7 (FBXW7) is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. FBXW7 was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene.
Immunogen :
Human recombinant protein fragment corresponding to amino acids 1-354 of FBXW7 produced in E.coli
Format :
Liquid
Applications w/Dilutions :
Immunohistochemistry (Paraffin): 1:150, Western Blot: 1:2,000
Aliases :
1110001A17Rik; AGO; archipelago; Archipelago homolog; CDC4; DKFZp686F23254; F-box and WD repeat domain containing 7; F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase; F-box and WD-40 domain protein 7; F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila); F-box and WD-40 domain protein 7, archipelago homolog; F-box and WD-40 domain-containing protein 7; f-box only protein 30; F-box protein FBW7; F-box protein FBX30; F-box protein Fbxw6; F-box protein SEL-10; F-box/WD repeat-containing protein 7; F-box-WD40 repeat protein 6; FBW6; FBW7; Fbwd6; FBX30; Fbxo30; FBXW6; FBXW7; FLJ11071; FLJ16457; hAgo; hCdc4; homolog of C elegans sel-10; SEL10; SEL-10
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA