SCF Monoclonal Antibody (OTI6E5) | Invitrogen MA5-26329 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

SCF Monoclonal Antibody (OTI6E5)

catalog :

MA5-26329

quantity :

100 uL

price :

US 514.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

OTI6E5

The same clone is also sold as:

OriGene: TA507211BM, CF507211, TA507211, TA507211AM, TA507211S

reactivity :

human

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

product information

Product Type :

Antibody

Product Name :

SCF Monoclonal Antibody (OTI6E5)

Catalog # :

MA5-26329

Quantity :

100 uL

Price :

US 514.00

Clonality :

Monoclonal

Purity :

Affinity Chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Immunohistochemistry (Paraffin): 1:150, Western Blot: 1:4,000

Species :

Human

Clone :

OTI6E5

Isotype :

IgG1

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and the activation of signalling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase pathways. SCF expression leads to the induction of mast cell survival and the expression and release of histamine, pro-inflammatory cytokines and chemokines. The inhibition of the SCF/c-Kit pathway leads to a decrease in histamine levels, mast cell and eosinophil infiltration, IL-4 production and airway hyperresponsiveness, suggesting this pathway may be a useful therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist.

Immunogen :

Full length human recombinant protein of KITLG produced in HEK293T cell

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 1:150, Western Blot: 1:4,000

Aliases :

710-712; blz; c-Kit ligand; Clo; cloud gray; Con; contrasted; CSF; DCUA; DFNA69; DKFZp686F2250; familial progressive hyperpigmentation 2; FPH2; FPHH; Gb; grizzle-belly; hematopoietic growth factor KL; H-SCF; Kit ligand; Kitl; Kitlg; kit-ligand; KL-1; Mast cell growth factor; MGF; M-SCF; Processed kit ligand; SCF; SF; SHEP7; sKITLG; Sl; SLF; Soluble KIT ligand; Steel factor; steel factor/kit ligand; stem cell factor; stem cell factor KL-1; stem cell factor, CSF