This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Alpha A Crystallin Monoclonal Antibody (OTI3B12)
catalog :
MA5-26164
quantity :
100 uL
price :
US 514.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
OTI3B12

The same clone is also sold as:
reactivity :
human
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section
product information
Product Type :
Antibody
Product Name :
Alpha A Crystallin Monoclonal Antibody (OTI3B12)
Catalog # :
MA5-26164
Quantity :
100 uL
Price :
US 514.00
Clonality :
Monoclonal
Purity :
Affinity Chromatography
Host :
Mouse
Reactivity :
Human
Applications :
Immunocytochemistry: 1:100, Immunohistochemistry (Paraffin): 1:150, Western Blot: 1:2,000
Species :
Human
Clone :
OTI3B12
Isotype :
IgG2b
Storage :
-20 C, Avoid Freeze/Thaw Cycles
Description :
Lens proteins consist almost entirely of crystallins (about 95%). Crystallins are also found vertebrate skeletal muscle tissue. In the lens, their structural function is to assist in maintaining the proper refractive index of the lens. The mammalian lens contains 3 major classes of crystallins: alpha, beta, and gamma. Alpha-crystallin is the largest of the crystallins and is composed of 2 primary gene products-alpha-A and alpha-B. There are at least 5 different proteins comprising the beta-crystallins. The gamma-crystallins are monomeric, but there are at least 5 gamma crystallins identified in bovine and rat lens. Alpha-Crystallin comprises 40% of total lens protein composition. In addition to maintaining proper refractive index, it also functions in a chaperone like manner by preventing the formation of aggregates possibly leading to cataract formation. It is believed that the phosphorylated states of the alpha-crystallin occur in response to cellular stress and may serve a structural control function and play a role in protein maintenance. Alpha-B crystallin has been linked to Alexander's disease where it accumulates in brain cells of those afflicted.
Immunogen :
Full length human recombinant protein of CRYAA produced in HEK293T cell
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: 1:100, Immunohistochemistry (Paraffin): 1:150, Western Blot: 1:2,000
Aliases :
[a]A-crystallin; Acry 1; Acry-1; alpha A crystallin; alpha crystallin A chain; alpha-A-crystallin; alpha-crystallin A chain; Alpha-crystallin A(1-151); Alpha-crystallin A(1-156); Alpha-crystallin A(1-157); Alpha-crystallin A(1-162); Alpha-crystallin A(1-163); Alpha-crystallin A(1-165); Alpha-crystallin A(1-168); Alpha-crystallin A(1-172); Alpha-crystallin A2 chain; Alpha-crystallin A2(1-162); Alpha-crystallin A2(1-168); Alpha-crystallin A2(1-172); CRYA 1; Crya1; Crya-1; CRYAA; CRYAA2; Crystallin Alpha 1; crystallin alpha A; crystallin, alpha 1; crystallin, alpha A; Crystallin, alpha polypeptide A; crystallin, alpha-1; CTRCT9; DAcry-1; Heat shock protein beta-4; HSPB 4; HSPB4; human alphaA-crystallin (CRYA1); lens opacity 18; LOC102724652; lop18; small heat shock protein; wu:fc06h04; zgc:92036
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA