STING Monoclonal Antibody (OTI4H1) | Invitrogen MA5-26030 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

STING Monoclonal Antibody (OTI4H1)

catalog :

MA5-26030

quantity :

100 uL

price :

US 542.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

OTI4H1

The same clone is also sold as:

Bio-Rad: VMA00456
OriGene: CF505023, TA505023AM, TA505023BM, TA505023, TA505023S
Novus Biologicals: NBP2-74402, NBP2-45998

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

citations: 1

Reference
Liu H, Ghosh S, Vaidya T, Bammidi S, Huang C, Shang P, et al. Activated cGAS/STING signaling elicits endothelial cell senescence in early diabetic retinopathy. JCI Insight. 2023;8: pubmed publisher

product information

Product Type :

Antibody

Product Name :

STING Monoclonal Antibody (OTI4H1)

Catalog # :

MA5-26030

Quantity :

100 uL

Price :

US 542.00

Clonality :

Monoclonal

Purity :

Affinity Chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Immunocytochemistry: 1:100-1:1,000, Immunohistochemistry (Paraffin): 1:100, Immunoprecipitation: Assay-dependent, Western Blot: 1:2,000

Species :

Human

Clone :

OTI4H1

Isotype :

IgG2a

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

STING is a 379 amino acid containing signaling protein that acts as an important component of innate immune signaling. This signaling protein is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon (IFN-alpha and IFN-beta) and exert a potent anti-viral state following expression. STING may have translocon function, the translocon possibly being able to influence the induction of type I interferons and is also involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II) thus facilitating the detection of intracellular viral RNA species as well as B-form DNA and mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Generally seen in endoplasmic reticulum membrane, cell membrane and mitochondrion outer membrane, it is ubiquitously expressed in most of tissues.

Immunogen :

Full length human recombinant protein of TMEM173 produced in HEK293T cell

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:100-1:1,000, Immunohistochemistry (Paraffin): 1:100, Immunoprecipitation: Assay-dependent, Western Blot: 1:2,000

Aliases :

2610307O08Rik; endoplasmic reticulum IFN stimulator; endoplasmic reticulum interferon stimulator; ERIS; hMITA; hSTING; hypothetical LOC533661; mediator of IRF3 activation; Mita; mitochondrial mediator of IRF3 activation; mitochondrial transmembrane protein 173; MMITA; Mpys; mSTING; NET23; N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner; poSTING; RGD1562552; rSTING; SAVI; Stimulator of interferon genes protein; stimulator of interferon response cGAMP interactor 1; STING; STING1; tm173; Tmem173; Transmembrane protein 173