RYBP Monoclonal Antibody (OTI2B4) | Invitrogen MA5-25946 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

RYBP Monoclonal Antibody (OTI2B4)

catalog :

MA5-25946

quantity :

100 uL

price :

US 514.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

OTI2B4

The same clone is also sold as:

OriGene: TA504651S, TA504651, CF504651, TA504651AM, TA504651BM

reactivity :

human, mouse, dogs

application :

western blot

product information

Product Type :

Antibody

Product Name :

RYBP Monoclonal Antibody (OTI2B4)

Catalog # :

MA5-25946

Quantity :

100 uL

Price :

US 514.00

Clonality :

Monoclonal

Purity :

Affinity Chromatography

Host :

Mouse

Reactivity :

Canine, Human, Mouse, Non-human primate

Applications :

Western Blot: 1:2,000

Species :

Canine, Human, Mouse, Non-human primate

Clone :

OTI2B4

Isotype :

IgG1

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

RYBP involves component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females. May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites. Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes. May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis. May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. May bind to DNA. May play a role in the repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3.

Immunogen :

Full length human recombinant protein of RYBP produced in E.coli

Format :

Liquid

Applications w/Dilutions :

Western Blot: 1:2,000

Aliases :

2410018J24Rik; AAP1; APAP-1; apoptin-associating protein 1; Death effector domain-associated factor; DEDAF; DED-associated factor; RING1 and YY1 binding protein; RING1 and YY1-binding protein; ring1 interactor RYBP; Rybp; YEAF1; YY1 and E4TF1 associated factor 1; YY1 and E4TF1-associated factor 1