LGR5 Monoclonal Antibody (OTI2A2) | Invitrogen MA5-25644 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

LGR5 Monoclonal Antibody (OTI2A2)

catalog :

MA5-25644

quantity :

100 uL

price :

US 510.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

OTI2A2

The same clone is also sold as:

OriGene: TA400002, TA400006, TA503316, CF503316, TA400031, TA400001, TA503316S, TA400007, TA400003
Abcam: ab273092

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section

citations: 8

Reference
Chae S, Du M, Son J, Zhu M. Exercise improves homeostasis of the intestinal epithelium by activation of apelin receptor-AMP-activated protein kinase signalling. J Physiol. 2023;601:2371-2389 pubmed publisher
Park S, Kang S, Paek J, Georgescu A, Chang J, Yi A, et al. Geometric engineering of organoid culture for enhanced organogenesis in a dish. Nat Methods. 2022;19:1449-1460 pubmed publisher
Zollner A, Koch R, Jukic A, Pfister A, Meyer M, R xf6 ssler A, et al. Postacute COVID-19 is Characterized by Gut Viral Antigen Persistence in Inflammatory Bowel Diseases. Gastroenterology. 2022;163:495-506.e8 pubmed publisher
Ramezanpour M, Bolt H, Hon K, Shaghayegh G, Rastin H, Fenix K, et al. Characterization of human nasal organoids from chronic rhinosinusitis patients. Biol Open. 2022;11: pubmed publisher
AbdelMageed M, Ismail H, Olsson L, Lindmark G, Hammarstr xf6 m M, Hammarstr xf6 m S, et al. Clinical Significance of Stem Cell Biomarkers EpCAM, LGR5 and LGR4 mRNA Levels in Lymph Nodes of Colon Cancer Patients. Int J Mol Sci. 2021;23: pubmed publisher
Hu L, Xu J, Wang X, Feng L, Zhang C, Wang J, et al. Bone Morphogenetic Protein 4 Alleviates DSS-Induced Ulcerative Colitis Through Activating Intestinal Stem Cell by Target ID3. Front Cell Dev Biol. 2021;9:700864 pubmed publisher
Li W, Zhang N, Jin C, Long M, Rajabi H, Yasumizu Y, et al. MUC1-C drives stemness in progression of colitis to colorectal cancer. JCI Insight. 2020;5: pubmed publisher
Shin J, Ko J, Choi C, Lee Y, Seo Y, Lee J, et al. Deficiency of Crif1 in hair follicle stem cells retards hair growth cycle in adult mice. PLoS ONE. 2020;15:e0232206 pubmed publisher

product information

Product Type :

Antibody

Product Name :

LGR5 Monoclonal Antibody (OTI2A2)

Catalog # :

MA5-25644

Quantity :

100 uL

Price :

US 510.00

Clonality :

Monoclonal

Purity :

Affinity Chromatography

Host :

Mouse

Reactivity :

Human, Mouse

Applications :

Flow Cytometry: 1:100, Immunocytochemistry: 1:100, Immunohistochemistry (Paraffin): 1:150, Immunoprecipitation: 2 ug/ 500 ul, Western Blot: 1:2,000

Species :

Human, Mouse

Clone :

OTI2A2

Isotype :

IgG1

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

G protein-coupled receptor GPR49 has been reported to be expressed in brain, skeletal muscle, placenta, and spinal cord. ESTs have been isolated from normal human brain (amygdala), embryo, and placenta libraries and from human germ cell, uterus, and brain libraries. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This 'turn-off' activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.

Immunogen :

Human recombinant protein fragment corresponding to amino acids 250-550 of LGR5 produced in HEK293T cell

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1:100, Immunocytochemistry: 1:100, Immunohistochemistry (Paraffin): 1:150, Immunoprecipitation: 2 ug/ 500 ul, Western Blot: 1:2,000

Aliases :

Fex; follicle expressed hormone; G protein-coupled receptor 49; GPR49; GPR67; G-protein coupled receptor 49; G-protein coupled receptor 67; G-protein coupled receptor HG38; GRP49; HG38; leucine rich repeat containing G protein coupled receptor 5; leucine rich repeat containing G protein-coupled receptor 5; leucine-rich repeat containing G protein-coupled receptor 5; leucine-rich repeat-containing G protein-coupled receptor 5; leucine-rich repeat-containing G-protein coupled receptor 5; Lgr5; orphan G protein-coupled receptor HG38; orphan G-protein coupled receptor FEX