This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
SATB1 Monoclonal Antibody (OTI11E8)
catalog :
MA5-24961
quantity :
100 uL
price :
US 552.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
OTI11E8

The same clone is also sold as:
reactivity :
human
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section
product information
Product Type :
Antibody
Product Name :
SATB1 Monoclonal Antibody (OTI11E8)
Catalog # :
MA5-24961
Quantity :
100 uL
Price :
US 552.00
Clonality :
Monoclonal
Purity :
Affinity Chromatography
Host :
Mouse
Reactivity :
Human
Applications :
ChIP Assay: 2.5 ug/10^6 cells, Flow Cytometry: 1:100, Immunocytochemistry: 1:100, Immunohistochemistry (Paraffin): 1:50, Western Blot: 1:2,000
Species :
Human
Clone :
OTI11E8
Isotype :
IgG1
Storage :
-20 C, Avoid Freeze/Thaw Cycles
Description :
SATB1 (DNA-binding protein SATB1) is a crucial silencing factor that contributes to the initiation of X inactiviation mediated by Xist RNA that occurs during embryogenesis and in lymphoma. SATB1 binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence, and at nuclear matrix- or scaffold-associated regions. It is thought to recognize the sugar-phosphate structure of double-stranded DNA. SATB1 is also a transcriptonal repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner by binding to matrix attachment regions of DNA and inducing a local chromatin-loop remodeling. SATB1 modulates the genes that are essential in the maturatio of the immune T-cell CD8SP from thymocytes. Alu-like motifs and SATB1-binding sites provide an unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL1 and IL2RA in T-cells by binding to the same domain as HDAC1.
Immunogen :
Full length human recombinant protein of SATB1 produced in HEK293T cell
Format :
Liquid
Applications w/Dilutions :
ChIP Assay: 2.5 ug/10^6 cells, Flow Cytometry: 1:100, Immunocytochemistry: 1:100, Immunohistochemistry (Paraffin): 1:50, Western Blot: 1:2,000
Aliases :
2610306G12Rik; AW413156; DNA-binding protein SATB1; SATB homeobox 1; Satb1; special AT-rich sequence binding protein 1; special AT-rich sequence binding protein 1 (binds to nuclear matrix/scaffold-associating DNA); special AT-rich sequence-binding protein 1
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA