TSPO Recombinant Rabbit Monoclonal Antibody (4H2) | Invitrogen MA5-24844 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TSPO Recombinant Rabbit Monoclonal Antibody (4H2)

catalog :

MA5-24844

quantity :

100 uL

price :

US 530.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

4H2

reactivity :

human, mouse

application :

western blot, immunocytochemistry

citations: 2

Reference
Mahmud F, Du Y, Greif E, Boucher T, Dannals R, Mathews W, et al. Osteopontin/secreted phosphoprotein-1 behaves as a molecular brake regulating the neuroinflammatory response to chronic viral infection. J Neuroinflammation. 2020;17:273 pubmed publisher
Tong J, Williams B, Rusjan P, Mizrahi R, Lacapere J, McCluskey T, et al. Concentration, distribution, and influence of aging on the 18 kDa translocator protein in human brain: Implications for brain imaging studies. J Cereb Blood Flow Metab. 2020;40:1061-1076 pubmed publisher

product information

Product Type :

Antibody

Product Name :

TSPO Recombinant Rabbit Monoclonal Antibody (4H2)

Catalog # :

MA5-24844

Quantity :

100 uL

Price :

US 530.00

Clonality :

Recombinant Monoclonal

Purity :

Affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Immunocytochemistry: 1:50-1:200, Western Blot: 1:1,000-1:5,000

Species :

Human, Mouse

Clone :

4H2

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Mitochondrial peripheral-type benzodiazepine receptor (PBR) is an indispensable element of the steroidogenic machinery, where it mediates the delivery of cholesterol to the inner mitochondrial side chain cleavage cytochrome P-450 upon ligand activation. PBR is composed of three subunits, an isoquinoline binding site, a voltage-dependent anion channel and an adenine nucleotide carrier. PBR is genetically conserved from bacteria to humans and in humans is widely expressed in peripheral organs, whereas in the brain, it is sparse and located mainly in glial cells. Peroxisome proliferator perfluordecanoic acid (PFDA) inhibits the Leydig cell steroidogenesis by affecting PBR mRNA stability, thus inhibiting PBR expression, cholesterol transport into the mitochondria and subsequent steroid formation. A cytoplasmic protein, PRAX-1 ( peripheral benzodiazepine receptor-associated protein 1), is found to specifically interact with PBR.

Immunogen :

Recombinant TSPO.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:50-1:200, Western Blot: 1:1,000-1:5,000

Aliases :

Benzodiazepin receptor (peripheral); benzodiazepine peripheral binding site; benzodiazepine receptor, peripheral; BPBS; BZRP; DBI; IBP; isoquinoline-binding protein; MBR; mDRC; mitochondrial benzodiazepine receptor; OTTHUMP00000028891; PBR; PBS; peripheral-type benzodiazepine receptor; pk18; PKBS; PTBR; Ptbzr; PTBZR02; RATPTBZR02; translocator protein; translocator protein (18kDa); TSPO; Tspo1