This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
SIAH1/SIAH2 Monoclonal Antibody (8G7H12)
catalog :
MA5-24781
quantity :
500 uL
price :
US 474.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
8G7H12

The same clone is also sold as:
reactivity :
human, rat, pigs , zebrafish , fruit fly
application :
western blot, immunoprecipitation
citations: 1
Reference
Hu R, Xu B, Ma J, Li L, Zhang L, Wang L, et al. LINC00963 promotes the malignancy and metastasis of lung adenocarcinoma by stabilizing Zeb1 and exosomes-induced M2 macrophage polarization. Mol Med. 2023;29:1 pubmed publisher
product information
Product Type :
Antibody
Product Name :
SIAH1/SIAH2 Monoclonal Antibody (8G7H12)
Catalog # :
MA5-24781
Quantity :
500 uL
Price :
US 474.00
Clonality :
Monoclonal
Host :
Mouse
Reactivity :
Drosophila, Human, Porcine, Rat, Zebrafish
Applications :
Immunoprecipitation: 1:10-1:500, Western Blot: 1:500
Species :
Drosophila, Human, Porcine, Rat, Zebrafish
Clone :
8G7H12
Isotype :
IgG1
Storage :
4 C, do not freeze
Description :
SIAH, the human homologue of the Drosophila seven in absentia (sina) gene, is a tumor suppressor protein that is expressed in intestinal epithelium and activated during apoptosis. Human SIAH proteins are produced as two distinct gene products, SIAH-1, and a slightly larger protein SIAH-2, which share a highly conserved C-terminal sequence and differ in their N-terminal regions. SIAH-1 is a 32 kDa protein that contains an N-terminal RING-finger domain, which is required for proteolysis, and a cystein-rich C-terminal domain, which regulates oligomerization and SIAH binding to target proteins. As a tumor suppressor, SIAH-1 binds DCC (deleted in colorectal cancer) and regulates DCC degradation via the ubiquitin-proteasome pathway. SIAH-1 also binds a Bcl-2 related protein, Bag-1, thereby inhibiting cell growth. The majority of SIAH-1 is localized to the nucleus, however a small percentage is detected in the cytoplasm. This nuclear localization suggests that SIAH proteins may interact with other nuclear matrix proteins and DNA.
Immunogen :
Synthetic peptide made to a C-terminal portion of the drosophila SINA protein (within residues 280-331).
Format :
Liquid
Applications w/Dilutions :
Immunoprecipitation: 1:10-1:500, Western Blot: 1:500
Aliases :
AA415433; E3 ubiquitin-protein ligase Siah1; E3 ubiquitin-protein ligase SIAH2; EC 6.3.2; FLJ08065; hSIAH1; hSiah2; HUMSIAH; id:ibd2635; mSiah2; RING-type E3 ubiquitin transferase SIAH1; RING-type E3 ubiquitin transferase SIAH2; seven in absentia 1A; seven in absentia 2; seven in absentia homolog 1; Seven in absentia homolog 2; SIAH; siah E3 ubiquitin protein ligase 1; siah E3 ubiquitin protein ligase 2; Siah1; siah-1; Siah1a; Siah-1a; Siah2; siah-2; Sinh2; zgc:56026
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA