This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
SIAH2 Monoclonal Antibody (24E6H3)
catalog :
MA5-24780
quantity :
500 uL
price :
US 474.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
24E6H3

The same clone is also sold as:
reactivity :
human, pigs , fruit fly
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
product information
Product Type :
Antibody
Product Name :
SIAH2 Monoclonal Antibody (24E6H3)
Catalog # :
MA5-24780
Quantity :
500 uL
Price :
US 474.00
Clonality :
Monoclonal
Host :
Mouse
Reactivity :
Drosophila, Human, Porcine
Applications :
Flow Cytometry: 1:10, Immunocytochemistry: 1:10, Immunohistochemistry (Frozen): 1:40-1:50, Immunohistochemistry (Paraffin): 1:40-1:50, Western Blot: Assay-Dependent
Species :
Drosophila, Human, Porcine
Clone :
24E6H3
Isotype :
IgG1
Storage :
4 C, do not freeze
Description :
SIAH-2 (seven in absentia homolog 2) is an E3 ligase that catalyzes ubiquitination and proteasome-mediated degradation of protein substrates. SIAH-2 encodes a 324 amino acid protein that shares 77% identity with human SIAH-1 and 68% identity with the Drosophila sina (seven in absentia) gene, on which development of the Drosophila R7 photoreceptor is dependent. SIAH-2 targets TRAF2 (which regulates cell responses to stress and cytokines through the regulation of key stress-signaling cascades) for degradation under stress conditions such as hypoxia. It targets HIF-1 alpha prolyl hydroxylase 3 (PHD3) for degradation upon exposure to hypoxic conditions, which coincides with an increase in SIAH-2 transcription. SIAH-2 can decrease TNF-alpha-dependent induction of JNK activity and transcriptional activation of NFkB. SIAH-2 null mice subjected to hypoxia display an impaired respiratory response and reduced levels of hemoglobin.
Immunogen :
Synthetic peptide made to an N-terminal portion of the drosophila SIAH2 protein (within residues 1-100).
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1:10, Immunocytochemistry: 1:10, Immunohistochemistry (Frozen): 1:40-1:50, Immunohistochemistry (Paraffin): 1:40-1:50, Western Blot: Assay-Dependent
Aliases :
AA415433; E3 ubiquitin-protein ligase SIAH2; EC 6.3.2; hSiah2; mSiah2; RING-type E3 ubiquitin transferase SIAH2; seven in absentia 2; seven in absentia homolog 2; siah E3 ubiquitin protein ligase 2; SIAH2; siah-2; Sinh2
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA