SCN5A Monoclonal Antibody (4G8:1G7) | Invitrogen MA5-24779 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

SCN5A Monoclonal Antibody (4G8:1G7)

catalog :

MA5-24779

quantity :

100 ug

price :

US 464.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4G8:1G7

The same clone is also sold as:

Santa Cruz Biotechnology: sc-81631

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry

citations: 2

Reference
Velázquez R, Ferreira E, Tran A, Turner E, Belfiore R, Branca C, et al. Acute tau knockdown in the hippocampus of adult mice causes learning and memory deficits. Aging Cell. 2018;:e12775 pubmed publisher
Benford H, Bolborea M, Pollatzek E, Lossow K, Hermans Borgmeyer I, Liu B, et al. A sweet taste receptor-dependent mechanism of glucosensing in hypothalamic tanycytes. Glia. 2017;65:773-789 pubmed publisher

product information

Product Type :

Antibody

Product Name :

SCN5A Monoclonal Antibody (4G8:1G7)

Catalog # :

MA5-24779

Quantity :

100 ug

Price :

US 464.00

Clonality :

Monoclonal

Purity :

purified

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 1:10-1:1,000, Immunocytochemistry: 10 ug/mL, Immunohistochemistry: 1:10-1:500, Immunoprecipitation: 1:10-1:500, Radioimmune assays: 1:100-1:2,000, Western Blot: 2 ug/mL

Species :

Human

Clone :

4G8:1G7

Isotype :

IgM

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Scn5a is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. Scn5a is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in Scn5a are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms of Scn5a. Voltage-gated sodium channesl (VGSCs) mediate regenerative cell membrane depolarization and conduction of electrical signalling in nerves and muscles. Expression of Scn5a is also detected in lymphocytes, glia, and fibroblasts. Further, Scn5a mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, Scn5a forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Functionally, Scn5a is responsible for the initial upstroke of the action potential and the channel inactivation is regulated by intracellular calcium levels. Voltage-gated sodium channels (NaV) are responsible for action potential initiation and propagation in excitable cells, including nerve, muscle, and neuroendocrine cell types. Scn5a are also expressed at low levels in non-excitable cells, where their physiological role is unclear. Diseases associated with SCN5A include Long Qt Syndrome-3 and Brugada Syndrome 1.

Immunogen :

Peptide (14mer) from an extracellular domain of Nav1.5

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1:10-1:1,000, Immunocytochemistry: 10 ug/mL, Immunohistochemistry: 1:10-1:500, Immunoprecipitation: 1:10-1:500, Radioimmune assays: 1:100-1:2,000, Western Blot: 2 ug/mL

Aliases :

cardiac tetrodotoxin-insensitive voltage-dependent sodium channel alpha subunit; CDCD2; CDCD2VF1; CIN5; CMD1E; CMPD2; HB1; HB2; HBBD; HH1; HH1CMD1E; ICCD; IVF; LQT3; LQT3SSS1CMPD2; mH1; Nav1.5; Nav1.5c; PFHB1; RATRSKM2X; RH1; RSkM2; RSKM2X; SCAL; Scn2x; SCN5A; SkM1; SkM2; sodium channel protein cardiac muscle subunit alpha; Sodium channel protein type 5 subunit alpha; sodium channel protein type V subunit alpha; sodium channel voltage-gated type V alpha polypeptide; sodium channel, voltage gated, type V alpha subunit; sodium channel, voltage-gated, type 5, alpha subunit; sodium channel, voltage-gated, type V, alpha; sodium channel, voltage-gated, type V, alpha polypeptide; sodium channel, voltage-gated, type V, alpha subunit; sodium voltage-gated channel alpha subunit 5; SSS1; VF1; voltage-gated sodium channel Nav1.5c; voltage-gated sodium channel subunit alpha Nav1.5