HBVgp3 Monoclonal Antibody | Invitrogen MA5-24712 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

HBVgp3 Monoclonal Antibody

catalog :

MA5-24712

quantity :

100µl

price :

330 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

Hepatitis B virus

application :

western blot

product information

Product Type :

Antibody

Product Name :

HBVgp3 Monoclonal Antibody

Catalog # :

MA5-24712

Quantity :

100µl

Price :

330 USD

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Virus

Applications :

Western Blot: 1.0 µg/mL

Species :

Virus

Isotype :

IgG

Storage :

-20° C, Avoid Freeze/Thaw Cycles

Description :

Multifunctional protein that may modulate protein degradation pathways, apoptosis, transcription, signal transduction, cell cycle progress, and genetic stability by directly or indirectly interacting with host factors.; Multifunctional protein that plays a role in silencing host antiviral defenses and promoting viral transcription. Does not seem to be essential for HBV infection. May be directly involved in development of cirrhosis and liver cancer (hepatocellular carcinoma). Most of cytosolic activities involve modulation of cytosolic calcium. The effect on apoptosis is controversial depending on the cell types in which the studies have been conducted. May induce apoptosis by localizing in mitochondria and causing loss of mitochondrial membrane potential. May also modulate apoptosis by binding host CFLAR, a key regulator of the death-inducing signaling complex (DISC). Promotes viral transcription by using the host E3 ubiquitin ligase DDB1 to target the SMC5-SMC6 complex to proteasomal degradation. This host complex would otherwise bind to viral episomal DNA, and prevents its transcription. Moderately stimulates transcription of many different viral and cellular transcription elements. Promoters and enhancers stimulated by HBx contain DNA binding sites for NF-kappa-B, AP-1, AP-2, c-EBP, ATF/CREB, or the calcium-activated factor NF-AT.

Immunogen :

synthetic peptide directed towards the middle region of human HBVgp3

Format :

Liquid

Applications w/Dilutions :

Western Blot: 1.0 µg/mL