5-Hydroxymethylcytosine Recombinant Rabbit Monoclonal Antibody (RM236)

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

5-Hydroxymethylcytosine Recombinant Rabbit Monoclonal Antibody (RM236)

catalog :

MA5-24695

quantity :

50 ug

price :

US 414.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

RM236

application :

immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, dot blot

citations: 1

Reference
Th xe1 E, Gagosian V, Canavez A, Schuck D, Brohem C, Gradia D, et al. In vitro evaluation of the inhalation toxicity of the cosmetic ingredient aluminum chlorohydrate. J Appl Toxicol. 2022;42:2016-2029 pubmed publisher

product information

Product Type :

Antibody

Product Name :

5-Hydroxymethylcytosine Recombinant Rabbit Monoclonal Antibody (RM236)

Catalog # :

MA5-24695

Quantity :

50 ug

Price :

US 414.00

Clonality :

Recombinant Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Chemical

Applications :

Dot Blot: 0.2-1 ug/mL, ELISA: 0.1-1 ug/mL, Flow Cytometry: 1-5 ug/mL, Immunocytochemistry: 0.5-2 ug/mL, Immunohistochemistry (Paraffin): 0.1-1 ug/mL, Immunoprecipitation: 0.2-2 ug/mL

Species :

Chemical

Clone :

RM236

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

5-hydroxymethylcytosine (5-hmC) has been recently discovered in mammalian DNA. 5-hmC results from the enzymatic conversion of 5-methylcytosine into 5-hydroxymethylcytosine by the TET family of oxygenases. Initially, the 5-hmC base had been identified in Purkinje neurons, in granule cells and embryonic stem cells where it is present at high levels (up to 0,6% of total nucleotides in Purkinje cells). A recent report indicates that 5-hmC is also abundant in brain tissue, especially in areas that are associated with higher cognitive functions.Early evidence suggests that 5-hmC may represent an intermediate in a new pathway which demethylates DNA, converting 5-mC to cytosine. Although its precise role has still to be shown, recent results indicate, however, that 5-hmC may play important roles distinct from 5-mC. This may open up entirely new perspectives in epigenetic studies.

Immunogen :

BSA-conjugated 5-hydroxymethylcytosine

Format :

Liquid

Applications w/Dilutions :

Dot Blot: 0.2-1 ug/mL, ELISA: 0.1-1 ug/mL, Flow Cytometry: 1-5 ug/mL, Immunocytochemistry: 0.5-2 ug/mL, Immunohistochemistry (Paraffin): 0.1-1 ug/mL, Immunoprecipitation: 0.2-2 ug/mL

Aliases :

5hmc; 5-hmc; 5-HydroxymethylCytidine; C5H7N3O2