B-Raf (V600E) Recombinant Rabbit Monoclonal Antibody (RM8) | Invitrogen MA5-24661 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

B-Raf (V600E) Recombinant Rabbit Monoclonal Antibody (RM8)

catalog :

MA5-24661

quantity :

100 ug

price :

US 480.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

RM8

The same clone is also sold as:

Novus Biologicals: NBP2-61503

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

citations: 3

Reference
Vittoria M, Kingston N, Kotynková K, Xia E, Hong R, Huang L, et al. Inactivation of the Hippo tumor suppressor pathway promotes melanoma. Nat Commun. 2022;13:3732 pubmed publisher
Chang T, Shanti R, Liang Y, Zeng J, Shi S, Alawi F, et al. LGR5+ epithelial tumor stem-like cells generate a 3D-organoid model for ameloblastoma. Cell Death Dis. 2020;11:338 pubmed publisher
Feddersen C, Schillo J, Varzavand A, Vaughn H, Wadsworth L, Voigt A, et al. Src-Dependent DBL Family Members Drive Resistance to Vemurafenib in Human Melanoma. Cancer Res. 2019;79:5074-5087 pubmed publisher

product information

Product Type :

Antibody

Product Name :

B-Raf (V600E) Recombinant Rabbit Monoclonal Antibody (RM8)

Catalog # :

MA5-24661

Quantity :

100 ug

Price :

US 480.00

Clonality :

Recombinant Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human

Applications :

ELISA: 0.5-2 ug/mL, Immunocytochemistry: 0.5-5 ug/mL, Immunohistochemistry (Paraffin): 0.5-5 ug/mL, Western Blot: 0.5-2 ug/mL

Species :

Human

Clone :

RM8

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

This gene, B-RAF/BRAF, encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome.

Immunogen :

Peptide corresponding to B-Raf V600E mutant.

Format :

Liquid

Applications w/Dilutions :

ELISA: 0.5-2 ug/mL, Immunocytochemistry: 0.5-5 ug/mL, Immunohistochemistry (Paraffin): 0.5-5 ug/mL, Western Blot: 0.5-2 ug/mL