REST Monoclonal Antibody (CL0381) | Invitrogen MA5-24606 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

REST Monoclonal Antibody (CL0381)

catalog :

MA5-24606

quantity :

100 uL

price :

US 532.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

CL0381

The same clone is also sold as:

Novus Biologicals: NBP2-42048
Abcam: ab211537

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

citations: 2

Reference
Schenk M, Humphrey S, Hossain A, Revill M, Pearsall S, Lallo A, et al. Soluble guanylate cyclase signalling mediates etoposide resistance in progressing small cell lung cancer. Nat Commun. 2021;12:6652 pubmed publisher
Pearsall S, Humphrey S, Revill M, Morgan D, Frese K, Galvin M, et al. The Rare YAP1 Subtype of SCLC Revisited in a Biobank of 39 Circulating Tumor Cell Patient Derived Explant Models: A Brief Report. J Thorac Oncol. 2020;15:1836-1843 pubmed publisher

product information

Product Type :

Antibody

Product Name :

REST Monoclonal Antibody (CL0381)

Catalog # :

MA5-24606

Quantity :

100 uL

Price :

US 532.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

ChIP Assay: Assay-dependent, Immunocytochemistry: 2-10 ug/ml, Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1.4 ug/mL

Species :

Human

Clone :

CL0381

Isotype :

IgG1

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier.

Immunogen :

Recombinant protein corresponding to Human REST

Format :

Liquid

Applications w/Dilutions :

ChIP Assay: Assay-dependent, Immunocytochemistry: 2-10 ug/ml, Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1.4 ug/mL

Aliases :

2610008J04Rik; AA407358; Neural-restrictive silencer factor; neuron restrictive silencer factor; neuron-restrictive silencer factor; NRSF; RE1 silencing transcription factor; RE1-silencing transcription factor; RE1-silencing transcription factor variant E1a/E2/E3/E4c; RE1-silencing transcription factor variant E1a/E2/E3/E5; RE1-silencing transcription factor variant E1a/E2/E3/N3a/E4i; RE1-silencing transcription factor variant E1a/E2/E3/N3c/E4; RE1-silencing transcription factor variant E1a/E2/E4; RE1-silencing transcription factor variant E1a/E2/E5; RE1-silencing transcription factor variant E1a/E2a/E2k; RE1-silencing transcription factor variant E1a/E2d/E4g; RE1-silencing transcription factor variant E1a/E2e/E4h; RE1-silencing transcription factor variant E1a/E2f/E4e; RE1-silencing transcription factor variant E1a/E2k/E2i/E3/E4j; RE1-silencing transcription factor variant E1b/E2/E3/E5; RE1-silencing transcription factor variant E1b/E2/E3/N3b/E4i; RE1-silencing transcription factor variant E1b/E2/E3/N3c/E4; RE1-silencing transcription factor variant E1b/E2a/E2k; RE1-silencing transcription factor variant E1b/E2c/E2j/E3/E4; RE1-silencing transcription factor variant E1b/E2e/E4h; RE1-silencing transcription factor variant E1c/E2/E3/E5; RE1-silencing transcription factor variant E1c/E2a/E2k; RE1-silencing transcription factor variant E1c/E2g/E3/E4; repressor binding to the X2 box; Rest; REST4; WT6; X2 box repressor; XBR; zinc finger transcription factor REST protein