Uromodulin Monoclonal Antibody (774056) | Invitrogen MA5-24374 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Uromodulin Monoclonal Antibody (774056)

catalog :

MA5-24374

quantity :

100 ug

price :

US 470.00

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

774056

reactivity :

mouse

application :

western blot, immunohistochemistry, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 3

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig 2	Hreha T, Collins C, Daugherty A, Twentyman J, Paluri N, Hunstad D. TGFβ1 orchestrates renal fibrosis following Escherichia coli pyelonephritis. Physiol Rep. 2020;8:e14401 pubmed publisher
	Li J, Liu H, Takagi S, Nitta K, Kitada M, Srivastava S, et al. Renal protective effects of empagliflozin via inhibition of EMT and aberrant glycolysis in proximal tubules. JCI Insight. 2020;5: pubmed publisher
	Dalghi M, Clayton D, Ruiz W, Al Bataineh M, Satlin L, Kleyman T, et al. Expression and distribution of PIEZO1 in the mouse urinary tract. Am J Physiol Renal Physiol. 2019;317:F303-F321 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Uromodulin Monoclonal Antibody (774056)

Catalog # :

MA5-24374

Quantity :

100 ug

Price :

US 470.00

Clonality :

Monoclonal

Purity :

Protein A/G

Host :

Rat

Reactivity :

Mouse

Applications :

Immunohistochemistry (Frozen): 8-25 ug/mL, Western Blot: 0.5 ug/mL

Species :

Mouse

Clone :

774056

Isotype :

IgG2a

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.

Immunogen :

Mouse myeloma cell line NS0-derived recombinant mouse Uromodulin Ser24-Ala618

Format :

Lyophilized

Applications w/Dilutions :

Immunohistochemistry (Frozen): 8-25 ug/mL, Western Blot: 0.5 ug/mL

Aliases :

ADMCKD2; FJHN; HNFJ; HNFJ1; MCKD2; Tamm-Horsfall urinary glycoprotein; THGP; THP; UMOD; Urehd1; urehr4; Urmodulin (Tamm-Horsfall protein); uromodulin; Uromodulin, secreted form; uromucoid; uromucoid uromucoid

more info or order :

Invitrogen product webpage