This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
PON3 Monoclonal Antibody (454929)
catalog :
MA5-24173
quantity :
100 ug
price :
US 414.00
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
454929

The same clone is also sold as:
reactivity :
human, mouse, rat
application :
western blot
product information
Product Type :
Antibody
Product Name :
PON3 Monoclonal Antibody (454929)
Catalog # :
MA5-24173
Quantity :
100 ug
Price :
US 414.00
Clonality :
Monoclonal
Purity :
Protein A/G
Host :
Rat
Reactivity :
Human, Mouse, Rat
Applications :
Western Blot: 0.5 ug/mL
Species :
Human, Mouse, Rat
Clone :
454929
Isotype :
IgG2a
Storage :
-20 C, Avoid Freeze/Thaw Cycles
Description :
Paraoxonase-1 (PON1) is a calcium-dependent ester hydrolase that is tightly associated with apoA-I in HDL. PON1 prevents the oxidation of LDL, thereby the formation of atherogenic oxidised-LDL. Polymorphisms of the human PON1 gene are correlated with coronary artery disease, indicating a genetic association between PON1 and coronary artery disease. PON1 activity is lower in subjects prone to development of atherosclerosis such as in type 1 and type 2 diabetes, familial hypercholesterolemia, and renal disease, indicating the involvement of PON1 in atherosclerosis development. PON2 is a ubiquitously expressed intracellular protein that can protect cells against oxidative damage. PON3 is similar to PON1 in activity but differs from it in substrate specificity. PON1 and PON3 are implicated in lowering the risk of developing coronary artery disease and atherosclerosis. Human PON3 protein shares the 3 conserved cysteine residues identified in PON1, suggesting their importance of in vivo activities. PON1-based catalytic scavengers can be a way to safe and effective organophosphate intoxication.
Immunogen :
E. coli-derived recombinant human PON3 Ala30-Leu354
Format :
Lyophilized
Applications w/Dilutions :
Western Blot: 0.5 ug/mL
Aliases :
2810004E20; AI786302; arylesterase 3; lactonase/esterase; paraoxanase-3; paraoxonase 3; PON3; Serum paraoxonase/lactonase 3
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA