B7-H4 Monoclonal Antibody (297219) | Invitrogen MA5-24006 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

B7-H4 Monoclonal Antibody (297219)

catalog :

MA5-24006

quantity :

100 ug

price :

US 474.00

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

297219

The same clone is also sold as:

R&D Systems: MAB2154, FAB2154G-100UG

reactivity :

mouse

application :

western blot, flow cytometry

product information

Product Type :

Antibody

Product Name :

B7-H4 Monoclonal Antibody (297219)

Catalog # :

MA5-24006

Quantity :

100 ug

Price :

US 474.00

Clonality :

Monoclonal

Purity :

Protein A/G

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.25 ug per million cells, Western Blot: 1 ug/mL

Species :

Mouse

Clone :

297219

Isotype :

IgG2b

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

B7-H4 (B7x, VTCN1) a costimulatory protein which is reported to function as a negative regulator of T-cell mediated immunity. Although B7-H4 binds an unknown receptor, it is thought to deliver an inhibitory signal to T-cells preventing their proliferation, cell cycle progression and interleukin-2 production. B7-H4 deficient mice are only minimally affected; suggesting B7-H4 is important in the fine tuning of the T-cell mediated immune response. B7-H4 is expressed on activated T-cells, B-cells, monocytes and dendritic cells. Aberrant expression has been associated with cancers of the lung, breast and ovary in humans. B7-H4 is expressed primarily on the membrane of lymphoid cells, and as an immunoinhibitory protein that interacts with receptors on the surface of T lymphocytes, it is involved in mediating cellular and humoral immune responses. Overexpression of B7-H4 is associated with certain malignancies, including ovarian and breast cancer, which may be a mechanism by which tumor cells suppress T cell immunity and facilitate tumor progression. Further, VTCN1 may be a useful biomarker for the early detection of ovarian cancer and Renal Cell Carcinoma (RCC).

Immunogen :

Mouse myeloma cell line NS0-derived recombinant mouse B7-H4 Phe29-Pro258

Format :

Lyophilized

Applications w/Dilutions :

Flow Cytometry: 0.25 ug per million cells, Western Blot: 1 ug/mL

Aliases :

B7 family member, H4; B7 homolog 4; B7 superfamily member 1; B7h.5; B7H4; B7-H4; B7s1; B7x; BC032925; EMBL:AAH95842.1}; FLJ22418; immune costimulatory protein B7-H4; PRO1291; Protein B7S1; RGD1311204; RP11-229A19.4; t cell costimulatory molecule B7x; T-cell costimulatory molecule B7x; UNQ659/PRO1291; VCTN1; V-set domain containing T cell activation inhibitor 1; V-set domain containing T-cell activation inhibitor 1; V-set domain-containing T-cell activation inhibitor 1; Vtcn1; vtcn1 {ECO:0000312