NLRP3 Monoclonal Antibody (768319) | Invitrogen MA5-23919 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

NLRP3 Monoclonal Antibody (768319)

catalog :

MA5-23919

quantity :

100 µg

price :

US 396.00

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

768319

reactivity :

human, mouse

application :

western blot, immunocytochemistry, flow cytometry

more info or order :

Invitrogen product webpage

citations: 4

Reference
Silva D, Candeias E, Esteves A, Magalhães J, Ferreira I, Nunes Costa D, et al. Microbial BMAA elicits mitochondrial dysfunction, innate immunity activation, and Alzheimer's disease features in cortical neurons. J Neuroinflammation. 2020;17:332 pubmed publisher
Huang J, Gandini M, Chen L, M Dahoma S, Stemkowski P, Chung H, et al. Hyperactivity of Innate Immunity Triggers Pain via TLR2-IL-33-Mediated Neuroimmune Crosstalk. Cell Rep. 2020;33:108233 pubmed publisher
Yoon J, Lee H, Kim H, Han B, Lee H, Lee Y, et al. Sauchinone Protects Renal Mesangial Cell Dysfunction against Angiotensin II by Improving Renal Fibrosis and Inflammation. Int J Mol Sci. 2020;21: pubmed publisher
He X, Zeng Y, Li G, Feng Y, Wu C, Liang F, et al. Extracellular ASC exacerbated the recurrent ischemic stroke in an NLRP3-dependent manner. J Cereb Blood Flow Metab. 2020;40:1048-1060 pubmed publisher

product information

Product Type :

Antibody

Product Name :

NLRP3 Monoclonal Antibody (768319)

Catalog # :

MA5-23919

Quantity :

100 µg

Price :

US 396.00

Clonality :

Monoclonal

Purity :

Protein A/G

Host :

Rat

Reactivity :

Human, Mouse

Applications :

Flow Cytometry: 2.5 µg/1x10^6 cells, Immunocytochemistry: 8-25 µg/mL, Western Blot: 2 µg/mL

Species :

Human, Mouse

Clone :

768319

Isotype :

IgG2a

Storage :

-20° C, Avoid Freeze/Thaw Cycles

Description :

This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site domain, and a leucine-rich repeat motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome, and neonatal-onset multisystem inflammatory disease. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.

Immunogen :

E. coli-derived recombinant mouse NLRP3/NALP3 Met1-Arg153

Format :

Lyophilized

Applications w/Dilutions :

Flow Cytometry: 2.5 µg/1x10^6 cells, Immunocytochemistry: 8-25 µg/mL, Western Blot: 2 µg/mL

Aliases :

AGTAVPRL; AII; AII/AVP; Angiotensin/vasopressin receptor AII/AVP-like; AVP; C1orf7; caterpiller protein 1.1; Cias1; CLR1.1; cold autoinflammatory syndrome 1 homolog; cold autoinflammatory syndrome 1 protein; cold autoinflammatory syndrome 1 protein homolog; Cold-induced autoinflammatory syndrome 1 protein; cryopyrin; FCAS; FCAS1; FCU; FLJ95925; mast cell maturation inducible protein 1; mast cell maturation-associated-inducible protein 1; Mmig1; MWS; NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3; NACHT, LRR and PYD containing protein 3; NACHT, LRR and PYD domains-containing protein 3; NACHT/LRR/pyrin domain-containing protein 3; NALP3; NLR family pyrin domain containing 3; NLR family, pyrin domain containing 3; Nlrp3; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3; PYPAF1; PYRIN-containing APAF1-like protein 1

more info or order :

Invitrogen product webpage