RELM alpha Monoclonal Antibody (226033) | Invitrogen MA5-23898 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

RELM alpha Monoclonal Antibody (226033)

catalog :

MA5-23898

quantity :

100 ug

price :

US 464.00

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

226033

The same clone is also sold as:

R&D Systems: MAB1523-100

reactivity :

mouse

application :

western blot, immunocytochemistry

product information

Product Type :

Antibody

Product Name :

RELM alpha Monoclonal Antibody (226033)

Catalog # :

MA5-23898

Quantity :

100 ug

Price :

US 464.00

Clonality :

Monoclonal

Purity :

Protein A/G

Host :

Rat

Reactivity :

Mouse

Applications :

Immunocytochemistry: 8-25 ug/mL, Western Blot: 1 ug/mL

Species :

Mouse

Clone :

226033

Isotype :

IgG2a

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

RELM alpha, also known as Resistin-like alpha or FIZZ1, is a small cytokine (88 aminoacids, MW 9.4 kDa) produced mostly by macrophages. Its highest constitutive expression has been observed in small peritoneal macrophages, alveolar macrophages and adipose tissue macrophages. It is strongly induced by IL-4 and IL-13. Together with Arginase 1 and Ym-1, RELM alpha is considered one of the hallmarks of the M2 polarization of mouse macrophages, however, macrophages polarized with IL-10 (M2c) express neither RELM alpha nor Arginase 1. Also, the expression patterns of RELM alpha and Arginase 1 in untreated tissue macrophages significantly differ. Elevated levels of RELM alpha may indicate parasitic infection. Humans do not have RELM alpha gene but human Resistin resembles mouse RELM alpha in respect to sequence, tissue distribution and function. Other members of RELM family in mouse: RELM beta, RELM gamma and Resistin display different tissue distribution and functional properties. RELM alpha plays an important role in parasite infection, mucosal inflammation and allergy.

Immunogen :

E. coli-derived recombinant mouse RELM alpha Asp24-Ser111

Format :

Lyophilized

Applications w/Dilutions :

Immunocytochemistry: 8-25 ug/mL, Western Blot: 1 ug/mL

Aliases :

1810019L16Rik; cysteine-rich secreted protein A12-gamma; Cysteine-rich secreted protein FIZZ1; Fizz1; Fizz-1; FIZZ2; found in inflammatory zone 1; Himf; HXCP2; Hypoxia-induced mitogenic factor; parasite-induced macrophage novel gene 1 protein; Pmng1; RELMa; RELMalpha; RELM-alpha; RELMb; RELMbeta; RELM-beta; resistin like alpha; resistin-like alpha; Retnla; Xcp2