Sclerostin Monoclonal Antibody (220902) | Invitrogen MA5-23897 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Sclerostin Monoclonal Antibody (220902)

catalog :

MA5-23897

quantity :

100 ug

price :

US 474.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

220902

The same clone is also sold as:

R&D Systems: MAB1406-100

reactivity :

human

application :

western blot, ELISA

citations: 3

Reference
Chen M, Yang D, Zhou Y, Yang C, Lin W, Liu J, et al. Colchicine Blocks Abdominal Aortic Aneurysm Development by Maintaining Vascular Smooth Muscle Cell Homeostasis. Int J Biol Sci. 2024;20:2092-2110 pubmed publisher
Nugraha A, Ramadhani N, Riawan W, Ihsan I, Ernawati D, Ridwan R, et al. Gingival Mesenchymal Stem Cells Metabolite Decreasing TRAP, NFATc1, and Sclerostin Expression in LPS-Associated Inflammatory Osteolysis In Vivo. Eur J Dent. 2022;: pubmed publisher
Kim J, Han W, Park T, Kim E, Bang I, Lee H, et al. Sclerostin inhibits Wnt signaling through tandem interaction with two LRP6 ectodomains. Nat Commun. 2020;11:5357 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Sclerostin Monoclonal Antibody (220902)

Catalog # :

MA5-23897

Quantity :

100 ug

Price :

US 474.00

Clonality :

Monoclonal

Purity :

Protein A/G

Host :

Mouse

Reactivity :

Human

Applications :

ELISA: 0.5-2 ug/mL (Detection), 2-8 ug/mL (Capture), Western Blot: 1 ug/mL

Species :

Human

Clone :

220902

Isotype :

IgG2b

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Sclerostin, a glycoprotein predominantly secreted by osteocytes, is a member of the Cerberus/DAN family of putative BMP antagonists that functions as an endogenous regulator of the canonical Wnt signaling pathway and an inhibitory regulator of bone homeostasis. Although expressed nearly exclusively by osteocytes, sclerostin can also be found at significant levels elsewhere, such as bone, bone marrow, cartilage, the kidney, and the liver, and has also been shown to be produced by hypertrophic chondrocytes and cementocytes. Like DKK family members DKK-1 and DKK-4, sclerostin plays an important regulatory role in the Wnt/beta-catenin signaling pathway by forming inhibitory complexes with LDL Receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/beta-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/beta-catenin signaling cascade. Sclerostin has also been shown to interact directly with LRP4 via its extracellular domain to facilitate inhibition of Wnt signaling, and can catabolically promote osteoclast activity by increasing osteocyte expression of RANKL. Sclerostin's critical involvement in the regulation of bone formation and resorption is emphasized by two bone dysplasia disorders, sclerosteosis and van Buchem disease (VBD), caused by rare autosomal recessive mutations that result in progressive bone overgrowth and hypermineralization due to markedly decreased sclerostin levels.

Immunogen :

Mouse myeloma cell line NS0-derived recombinant human SOST/Sclerostin Gln24-Tyr213

Format :

Lyophilized

Applications w/Dilutions :

ELISA: 0.5-2 ug/mL (Detection), 2-8 ug/mL (Capture), Western Blot: 1 ug/mL

Aliases :

5430411E23Rik; CDD; DAND6; sclerosteosis; sclerostin; SOST; SOST1; UNQ2976/PRO7455/PRO7476; VBCH