GITRL Monoclonal Antibody (109114) | Invitrogen MA5-23852 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

GITRL Monoclonal Antibody (109114)

catalog :

MA5-23852

quantity :

100 ug

price :

US 441.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

109114

The same clone is also sold as:

R&D Systems: MAB6942-100

reactivity :

human

application :

neutralization, flow cytometry

citations: 1

Reference
Li X, Liang L, Feng Y, De Vivo I, Giovannucci E, Tang J, et al. Height, height-related SNPs, and risk of non-melanoma skin cancer. Br J Cancer. 2017;116:134-140 pubmed publisher

product information

Product Type :

Antibody

Product Name :

GITRL Monoclonal Antibody (109114)

Catalog # :

MA5-23852

Quantity :

100 ug

Price :

US 441.00

Clonality :

Monoclonal

Purity :

Protein A/G

Host :

Mouse

Reactivity :

Human

Applications :

ELISA: 0.5-2 ug/mL (Detection), 2-8 ug/mL (Capture), Flow Cytometry: 2.5 ug per million cells, Neutralization: Assay-Dependent

Species :

Human

Clone :

109114

Isotype :

IgG1

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

The tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate numerous biological functions including cell proliferation, differentiation, and survival through regulating the activation of the transcription factor NF-kappa-B and various mitogen-activated protein kinases. The glucocorticoid-induced tumor necrosis factor receptor (GITR) is an emerging member of this family that is expressed on CD4+ CD25+ regulatory T cells and appears to have crucial immune regulation functions. Its ligand GITRL is expressed in endothelial and antigen-presenting cells and can activate NF-kappa-B, induce both pro- and anti-apoptotic effects, inhibit the suppressive activity of regulatory T cells, and co-stimulate responder T cells through GITR. Dominant negative forms of NIK and TRAF2 expressed in transfected 293 cells substantially inhibited NF-kappa-B activation, suggesting that the GITRL-GITR pathway involves both NIK and TRAF2.

Immunogen :

Sf 21-derived recombinant human GITR Ligand/TNFSF18Glu52-Ser177

Format :

Lyophilized

Applications w/Dilutions :

ELISA: 0.5-2 ug/mL (Detection), 2-8 ug/mL (Capture), Flow Cytometry: 2.5 ug per million cells, Neutralization: Assay-Dependent

Aliases :

Activation-inducible TNF-related ligand; AITR ligand; AITRL; GITR ligand; Gitrl; GITRLigand; Glucocorticoid-induced TNF-related ligand; glucocorticoid-induced TNFR-related protein ligand; glucocorticoid-induced-tumor necrosis factor receptor ligand; hGITRL; RP1-15D23.1; TL6; TNF superfamily member 18; Tnfsf18; TNLG2A; tumor necrosis factor (ligand) superfamily member 18; tumor necrosis factor (ligand) superfamily, member 18; tumor necrosis factor ligand 2A; tumor necrosis factor ligand superfamily member 18; tumor necrosis factor superfamily member 18; UNQ149/PRO175