IL4R Monoclonal Antibody (25463) | Invitrogen MA5-23814 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IL4R Monoclonal Antibody (25463)

catalog :

MA5-23814

quantity :

100 ug

price :

US 427.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

25463

The same clone is also sold as:

R&D Systems: FAB230P-100, MAB230-100, FAB230A-100, FAB230N-100

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section

citations: 1

Reference
Yu X, Robbie G, Wu Y, Esser M, Jensen K, Schwartz H, et al. Safety, Tolerability, and Pharmacokinetics of MEDI4893, an Investigational, Extended-Half-Life, Anti-Staphylococcus aureus Alpha-Toxin Human Monoclonal Antibody, in Healthy Adults. Antimicrob Agents Chemother. 2017;61: pubmed publisher

product information

Product Type :

Antibody

Product Name :

IL4R Monoclonal Antibody (25463)

Catalog # :

MA5-23814

Quantity :

100 ug

Price :

US 427.00

Clonality :

Monoclonal

Purity :

Protein A/G

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 0.25 ug per million cells, Immunocytochemistry: 5-15 ug/mL, Immunohistochemistry (Paraffin): 8-25 ug/mL, Neutralization: 3-6 ng/mL, Western Blot: 1 ug/mL

Species :

Human

Clone :

25463

Isotype :

IgG2a

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

IL4 Receptor alpha (IL4RA) is the alpha chain of the interleukin 4 receptor which binds to both interleukin 4 and interleukin 13 to regulate IgE production, chemokine and mucus production at sites of allergic inflammmation. The IL4 response is involved in promoting Th2 differentiation. The secreted extracellular domain of IL4R alpha, called sIL4R alpha, can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. It has no signaling abilities. Allelic variations in the IL4RA gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema.

Immunogen :

Sf 21-derived recombinant human IL-4 R Gly24-His232

Format :

Lyophilized

Applications w/Dilutions :

Flow Cytometry: 0.25 ug per million cells, Immunocytochemistry: 5-15 ug/mL, Immunohistochemistry (Paraffin): 8-25 ug/mL, Neutralization: 3-6 ng/mL, Western Blot: 1 ug/mL

Aliases :

582J2.1; CD124; il-4 receptor; IL-4 receptor alpha chain; IL-4 receptor subunit alpha; IL-4-binding protein; IL4-BP; Il4r; IL4R nirs variant 1; IL-4R subunit alpha; IL4RA; IL-4RA; IL-4R-alpha; interleukin 4 receptor; interleukin 4 receptor, alpha; interleukin-4 receptor alpha chain; interleukin-4 receptor subunit alpha; Soluble IL-4 receptor subunit alpha; Soluble interleukin-4 receptor subunit alpha