IL-10 Monoclonal Antibody (JES052A5) | Invitrogen MA5-23796 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IL-10 Monoclonal Antibody (JES052A5)

catalog :

MA5-23796

quantity :

500 ug

price :

US 524.00

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

JES052A5

reactivity :

mouse

application :

western blot, ELISA, neutralization, flow cytometry, blocking or activating experiments

more info or order :

Invitrogen product webpage

citations: 9

Published Application/Species/Sample/Dilution	Reference
blocking or activating experiments; mouse; 50 ug/ml	Reinwald S, Wiethe C, Westendorf A, Breloer M, Probst Kepper M, Fleischer B, et al. CD83 expression in CD4+ T cells modulates inflammation and autoimmunity. J Immunol. 2008;180:5890-7 pubmed
flow cytometry; mouse	Walsh C, Smith P, Fallon P. Role for CTLA-4 but not CD25+ T cells during Schistosoma mansoni infection of mice. Parasite Immunol. 2007;29:293-308 pubmed
flow cytometry; mouse; fig 6C	Erhardt A, Biburger M, Papadopoulos T, Tiegs G. IL-10, regulatory T cells, and Kupffer cells mediate tolerance in concanavalin A-induced liver injury in mice. Hepatology. 2007;45:475-85 pubmed
flow cytometry; mouse; fig 8	Mangan N, Van Rooijen N, McKenzie A, Fallon P. Helminth-modified pulmonary immune response protects mice from allergen-induced airway hyperresponsiveness. J Immunol. 2006;176:138-47 pubmed
flow cytometry; mouse; fig 7	Furze R, Selkirk M. Comparative dynamics and phenotype of the murine immune response to Trichinella spiralis and Trichinella pseudospiralis. Parasite Immunol. 2005;27:181-8 pubmed
flow cytometry; mouse; fig 8	Mangan N, Fallon R, Smith P, Van Rooijen N, McKenzie A, Fallon P. Helminth infection protects mice from anaphylaxis via IL-10-producing B cells. J Immunol. 2004;173:6346-56 pubmed
ELISA; mouse	Cabarrocas J, Piaggio E, Zappulla J, Desbois S, Mars L, Lassmann H, et al. A transgenic mouse model for T-cell ignorance of a glial autoantigen. J Autoimmun. 2004;22:179-89 pubmed
	Luo H, Luo T, Liu J, Wu F, Bai T, Ou C, et al. Macrophage polarization-associated lnc-Ma301 interacts with caprin-1 to inhibit hepatocellular carcinoma metastasis through the Akt/Erk1 pathway. Cancer Cell Int. 2021;21:422 pubmed publisher
	Jiang X, Chen D. LncRNA FAM83H-AS1 maintains intervertebral disc tissue homeostasis and attenuates inflammation-related pain via promoting nucleus pulposus cell growth through miR-22-3p inhibition. Ann Transl Med. 2020;8:1518 pubmed publisher

product information

Product Type :

Antibody

Product Name :

IL-10 Monoclonal Antibody (JES052A5)

Catalog # :

MA5-23796

Quantity :

500 ug

Price :

US 524.00

Clonality :

Monoclonal

Purity :

Protein A/G

Host :

Rat

Reactivity :

Mouse

Applications :

ELISA: 0.1-0.4 ug/mL (Detection), 2-8 ug/mL (Capture), Neutralization: 0.005-0.015 ug/mL, Western Blot: 1 ug/mL

Species :

Mouse

Clone :

JES052A5

Isotype :

IgG1

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

IL-10 encodes a protein that acts as a cytokine and is primarily produced by monocytes, with some production by lymphocytes. This cytokine has various effects on immunoregulation and inflammation, including down-regulating the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. Additionally, IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice have suggested that this cytokine is an essential immunoregulator in the intestinal tract. Mutations in this gene have been associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. Diseases associated with IL10 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1.

Immunogen :

E. coli-derived recombinant mouse IL-10

Format :

Lyophilized

Applications w/Dilutions :

ELISA: 0.1-0.4 ug/mL (Detection), 2-8 ug/mL (Capture), Neutralization: 0.005-0.015 ug/mL, Western Blot: 1 ug/mL

Aliases :

CSIF; cytokine; Cytokine synthesis inhibitory factor; GVHDS; H-IL-10; il 10; IL10; IL-10; IL-10 precursor; IL10A; IL10X; ILN; Interleukin; interleukin 10; Interleukin10; interleukin-10; MGC126450; MGC126451; RP11-262N9.1; T-cell growth inhibitory factor; TGIF

more info or order :

Invitrogen product webpage