This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
IL-15 Monoclonal Antibody (201136)
catalog :
MA5-23786
quantity :
500 ug
price :
US 484.00
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
201136

The same clone is also sold as:
reactivity :
mouse
application :
western blot, ELISA
citations: 3
Reference
Schmid A, Neri D. Design and characterisation of a novel interleukin-15 receptor alpha fusion protein and analysis of interleukin-15 complexation. PLoS ONE. 2019;14:e0219313 pubmed publisher
Christofaro D, Casonatto J, Vanderlei L, Cucato G, Dias R. Relationship between Resting Heart Rate, Blood Pressure and Pulse Pressure in Adolescents. Arq Bras Cardiol. 2017;108:405-410 pubmed publisher
Farooqi A, Li K, Fayyaz S, Chang Y, Ismail M, Liaw C, et al. Anticancer drugs for the modulation of endoplasmic reticulum stress and oxidative stress. Tumour Biol. 2015;36:5743-52 pubmed publisher
product information
Product Type :
Antibody
Product Name :
IL-15 Monoclonal Antibody (201136)
Catalog # :
MA5-23786
Quantity :
500 ug
Price :
US 484.00
Clonality :
Monoclonal
Purity :
Protein A/G
Host :
Rat
Reactivity :
Mouse
Applications :
ELISA: 0.1-0.4 ug/mL (Detection), 2-8 ug/mL (Capture), Western Blot: 1 ug/mL
Species :
Mouse
Clone :
201136
Isotype :
IgG2a
Storage :
-20 C, Avoid Freeze/Thaw Cycles
Description :
IL-15 (Interleukin 15 ) is a cytokine that regulates T and natural killer cell activation and proliferation. IL-15 and IL-2 share many biological activities as both have been found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between IL-15 and IL-2. IL-15 induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. In mouse, studies suggest that IL-15 may increase the expression of apoptosis inhibitor Bcl-xL, possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. IL-15 plays an important role in the growth and differentiation of T and B lymphocytes, natural killer cells, macrophages, and monocytes as well as activation of a number of important intracellular signaling molecules. As such, IL-15 could be essential for the immune responses, allograft rejection, and the pathogenesis of autoimmune diseases. Further, IL-15 is a widely expressed pro-inflammatory cytokine and has been shown to play a role in several inflammatory disorders, including rheumatoid arthritis, psoriasis and pulmonary inflammatory diseases. Emerging data suggest that IL-15 may serve as a good therapeutic target, as there appears to be a beneficial effect of IL-15 neutralization in models of psoriasis and diabetes.
Immunogen :
E. coli-derived recombinant mouse IL-15 Asn49-Ser162
Format :
Lyophilized
Applications w/Dilutions :
ELISA: 0.1-0.4 ug/mL (Detection), 2-8 ug/mL (Capture), Western Blot: 1 ug/mL
Aliases :
AI503618; il 15; Il15; IL-15; ILN; Interleukin; interleukin 15; Interleukin15; interleukin-15; MGC9721; M-IL-15
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA