NRG1 Monoclonal Antibody (147705) | Invitrogen MA5-23776 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

NRG1 Monoclonal Antibody (147705)

catalog :

MA5-23776

quantity :

500 ug

price :

US 480.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

147705

The same clone is also sold as:

R&D Systems: MAB3771-100

reactivity :

human

product information

Product Type :

Antibody

Product Name :

NRG1 Monoclonal Antibody (147705)

Catalog # :

MA5-23776

Quantity :

500 ug

Price :

US 480.00

Clonality :

Monoclonal

Purity :

Protein A/G

Host :

Mouse

Reactivity :

Human

Applications :

ELISA: 0.1-0.4 ug/mL (Detection), 2-8 ug/mL (Capture)

Species :

Human

Clone :

147705

Isotype :

IgG1

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specifically expressed and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains; and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentiation of epithelial, neuronal, glial, and other types of cells.

Immunogen :

E. coli-derived recombinant human NRG1-beta 1/HRG1-beta 1 Ser2-Lys246

Format :

Lyophilized

Applications w/Dilutions :

ELISA: 0.1-0.4 ug/mL (Detection), 2-8 ug/mL (Capture)

Aliases :

6030402G23Rik; Acetylcholine receptor-inducing activity; ARIA; Breast cancer cell differentiation factor p45; D230005F13Rik; GGF; GGF2; GGFII; Glial growth factor; glial growth factor 2; heregulin; heregulin, alpha (45kD, ERBB2 p185-activator); HGL; HRG; HRG1; HRGA; HRGalpha; MST131; MSTP131; NDF; Neu differentiation factor; neuregulin 1; neuregulin 1 type III beta 3; Neuregulin-1; NRG1; NRG-1; NRG1-IT2; pro-neuregulin-1, membrane-bound isoform; Pro-NRG1; sensory and motor neuron derived factor; Sensory and motor neuron-derived factor; SMDF; type I neuregulin 1; type III neuregulin 1