NGF Monoclonal Antibody (25623) | Invitrogen MA5-23717 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

NGF Monoclonal Antibody (25623)

catalog :

MA5-23717

quantity :

500 ug

price :

US 484.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

25623

The same clone is also sold as:

R&D Systems: MAB256-100

reactivity :

human

application :

neutralization

product information

Product Type :

Antibody

Product Name :

NGF Monoclonal Antibody (25623)

Catalog # :

MA5-23717

Quantity :

500 ug

Price :

US 484.00

Clonality :

Monoclonal

Purity :

Protein A/G

Host :

Mouse

Reactivity :

Human

Applications :

ELISA: 0.1-0.4 ug/mL (Detection), 2-8 ug/mL (Capture), Neutralization: 0.1-0.4 ug/mL

Species :

Human

Clone :

25623

Isotype :

IgG1

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Nerve growth factor (NGF) influences the survival and differentiation of a variety of neuronal and nonneuronal cells. The actions of this polypeptide result from binding to specific cell surface receptors which are present as both high and low affinity sites. Although both types of receptor bind NGF only the high affinity form is capable of signal transduction. Cross-linking studies with 125I-NGF have shown that the high affinity receptor of rat PC12 cells forms an Mr 158,000 complex with NGF while the low affinity receptor forms an Mr 100,000 complex. Full length cDNA clones for both the human and rat NGF receptor genes have been produced and sequenced, revealing greater than 90% homology between the two species. NGF exhibits nerve growth stimulating activity and is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Further, NGF stimulates division and differentiation of sympathetic and embryonic sensory neurons. Mutations in the NGF gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of NGF gene expression is associated with allergic rhinitis.

Immunogen :

Mouse myeloma cell line NS0-derived recombinant human beta-NGF Ser122-Ala241

Format :

Lyophilized

Applications w/Dilutions :

ELISA: 0.1-0.4 ug/mL (Detection), 2-8 ug/mL (Capture), Neutralization: 0.1-0.4 ug/mL

Aliases :

B nerve growth factor; beta ngf; beta-nerve growth factor; BetaNGF; beta-NGF; bNGF; b-NGF; HSAN5; MGC161426; MGC161428; Nerve growth factor; nerve growth factor (beta polypeptide); nerve growth factor, beta; nerve growth factor, beta polypeptide; nerve growth factor, beta subunit; NGF; NGF b; NGF ß; Ngfb; NGFbeta; NGFß; ß nerve growth factor; ß NGF; ßNGF