5-hydroxymethylcytosine Monoclonal Antibody (3I7) | Invitrogen MA5-23525 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

5-hydroxymethylcytosine Monoclonal Antibody (3I7)

catalog :

MA5-23525

quantity :

100 uL

price :

US 524.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3i7

application :

immunohistochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, dot blot

product information

Product Type :

Antibody

Product Name :

5-hydroxymethylcytosine Monoclonal Antibody (3I7)

Catalog # :

MA5-23525

Quantity :

100 uL

Price :

US 524.00

Clonality :

Monoclonal

Purity :

Antigen affinity chromatography

Host :

Mouse

Reactivity :

Chemical

Applications :

Dot Blot: Assay-dependent, Immunohistochemistry (Frozen): Assay-dependent, Immunohistochemistry (Paraffin): 1:100-1:1,000, Immunomicroscopy: Assay-dependent, Methylated DNA Immunoprecipitation: Assay-dependent, Peptide array: Assay-dependent

Species :

Chemical

Clone :

3I7

Isotype :

IgG2b

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

5-hydroxymethylcytosine (5-hmC) has been recently discovered in mammalian DNA. 5-hmC results from the enzymatic conversion of 5-methylcytosine into 5-hydroxymethylcytosine by the TET family of oxygenases. Initially, the 5-hmC base had been identified in Purkinje neurons, in granule cells and embryonic stem cells where it is present at high levels (up to 0,6% of total nucleotides in Purkinje cells). A recent report indicates that 5-hmC is also abundant in brain tissue, especially in areas that are associated with higher cognitive functions.Early evidence suggests that 5-hmC may represent an intermediate in a new pathway which demethylates DNA, converting 5-mC to cytosine. Although its precise role has still to be shown, recent results indicate, however, that 5-hmC may play important roles distinct from 5-mC. This may open up entirely new perspectives in epigenetic studies.

Immunogen :

5-HydroxymethylCytosine / 5-hmC

Format :

Liquid

Applications w/Dilutions :

Aliases :

5hmc; 5-hmc; 5-HydroxymethylCytidine; C5H7N3O2