Phospho-RNA pol II CTD (Ser2) Monoclonal Antibody | Invitrogen MA5-23510 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-RNA pol II CTD (Ser2) Monoclonal Antibody

catalog :

MA5-23510

quantity :

50 ug

price :

US 474.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunocytochemistry

more info or order :

Invitrogen product webpage

citations: 2

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig 6g	Niu Q, Liu Z, Alamer E, Fan X, Chen H, Endsley J, et al. Structure-guided drug design identifies a BRD4-selective small molecule that suppresses HIV. J Clin Invest. 2019;129:3361-3373 pubmed publisher
	Alamer E, Zhong C, Liu Z, Niu Q, Long F, Guo L, et al. Epigenetic Suppression of HIV in Myeloid Cells by the BRD4-Selective Small Molecule Modulator ZL0580. J Virol. 2020;94: pubmed publisher

product information

Product Type :

Antibody

Product Name :

Phospho-RNA pol II CTD (Ser2) Monoclonal Antibody

Catalog # :

MA5-23510

Quantity :

50 ug

Price :

US 474.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

ChIP Assay: 1-2 ug, ChIP-Sequencing: Assay-dependent, Immunocytochemistry: 1:500, Western Blot: 1:1,000

Species :

Human

Isotype :

IgG1

Storage :

-20 C or -80 C if preferred

Description :

RNA polymerase II is the enzyme responsible for the synthesis of mRNA and many non-coding RNAs. POLR2A encodes RNA polymerase II subunit B1 (RPB1), the largest subunit of RNA polymerase II. The C-terminal domain (CTD) of RPB1 contains tandem heptapeptide repeats with the consensus sequence YSPTSPS. Phosphorylation and other modifications within this sequence influence the recruitment of factors that regulate the transcription cycle. Recruitment of RNA processing factors to the elongation complex is coordinated by the phosphorylation of Serine-2 and Serine-5 residues within the CTD.

Immunogen :

Human YSPTSPS repeat in the B1 subunit of RNA polymerase II, phosphorylated at Ser2 of the repeat sequence.

Format :

Liquid

Applications w/Dilutions :

ChIP Assay: 1-2 ug, ChIP-Sequencing: Assay-dependent, Immunocytochemistry: 1:500, Western Blot: 1:1,000

Aliases :

220kDa; AW321876; DNA polymerase alpha 1 catalytic subunit; DNA polymerase alpha 1, 180 kDa; DNA polymerase alpha 1, catalytic subunit; DNA polymerase alpha catalytic subunit; DNA polymerase alpha catalytic subunit p180; DNA polymerase alpha p180 subunit; DNA polymerase alpha subunit I; DNA polymerase epsilon catalytic subunit; DNA polymerase epsilon catalytic subunit A; DNA polymerase II subunit A; DNA-directed RNA polymerase II largest subunit, RNA polymerase II 220 kd subunit; DNA-directed RNA polymerase II subunit A; DNA-directed RNA polymerase II subunit RPB1; DNA-directed RNA polymerase III largest subunit; DUN2; EC 2.7.7.6; G7a/Bat6Hom; hRPB220; hsRPB1; I79_002751; I79_016081; MGC75453; N0825; NSX; p180; Pol II S2p; POL2; Pola; Pola1; POLR2; POLR2A; POLRA; polymerase (DNA directed), alpha 1; polymerase (DNA directed), alpha 1, catalytic subunit; polymerase (DNA) alpha 1, catalytic subunit; polymerase (DNA-directed), alpha (70kD); Polymerase (RNA II (DNA directed), large polypeptide; polymerase (RNA) II (DNA directed) polypeptide A; polymerase (RNA) II (DNA directed) polypeptide A, 220kDa; polymerase (RNA) II subunit A; POLYMERASE II; polymerase, alpha 1; RNA; RNA POL2; RNA polymerase II 1; RNA polymerase II carboxy-terminal domain; RNA polymerase II C-terminal domain; RNA polymerase II largest subunit; RNA polymerase II subunit A; RNA polymerase II subunit B1; RNA-directed RNA polymerase II subunit RPB1; RP02; Rpb1; RPB220; RPBh1; Rpii215; RpIILS; RPO2; RPO21; Rpo2-1; RPOL2; SUA8; YNL262W

more info or order :

Invitrogen product webpage