HIP2 Monoclonal Antibody (1D10) | Invitrogen MA5-19073 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

HIP2 Monoclonal Antibody (1D10)

catalog :

MA5-19073

quantity :

100 ug

price :

US 474.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1D10

reactivity :

human

application :

western blot, ELISA

product information

Product Type :

Antibody

Product Name :

HIP2 Monoclonal Antibody (1D10)

Catalog # :

MA5-19073

Quantity :

100 ug

Price :

US 474.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

ELISA: Assay-Dependent, Western Blot: 1-5 ug/mL

Species :

Human

Clone :

1D10

Isotype :

IgG2a, kappa

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1.

Immunogen :

UBE2K (-, 1 a.a. ~ 40 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-Dependent, Western Blot: 1-5 ug/mL

Aliases :

AW492011; D5Ertd601e; DKFZp564C1216; DKFZp686J24237; E2 ubiquitin-conjugating enzyme K; E2(25K); E2-25k; HIP2; HIP-2; huntingtin interacting protein 2; huntingtin-interacting protein 2; HYPG; LIG; UBC1; UBE2K; Ubiquitin carrier protein; ubiquitin conjugating enzyme E2 K; ubiquitin conjugating enzyme E2K; ubiquitin-conjugating enzyme E2 K; Ubiquitin-conjugating enzyme E2(25K); ubiquitin-conjugating enzyme E2-25 KDA; ubiquitin-conjugating enzyme E2-25K; ubiquitin-conjugating enzyme E2K; ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast); ubiquitin-protein ligase