GUK1 Monoclonal Antibody (4C3-1A7) | Invitrogen MA5-19046 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

GUK1 Monoclonal Antibody (4C3-1A7)

catalog :

MA5-19046

quantity :

100 µg

price :

US 446

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4C3-1A7

reactivity :

human

application :

western blot, ELISA, immunoprecipitation

product information

Product Type :

Antibody

Product Name :

GUK1 Monoclonal Antibody (4C3-1A7)

Catalog # :

MA5-19046

Quantity :

100 µg

Price :

US 446

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

ELISA: Assay-Dependent, Immunoprecipitation: Assay-Dependent, Western Blot: 1-5 µg/mL

Species :

Human

Clone :

4C3-1A7

Isotype :

IgG2a, kappa

Storage :

-20° C, Avoid Freeze/Thaw Cycles

Description :

Guanylate kinase (GK) catalyzes the ATP-dependent phosphorylation of GMP into GDP. It is essential for recycling GMP and indirectly, cGMP. In prokaryotes (such as Escherichia coli), lower eukaryotes (such as yeast) and in vertebrates, GK is a highly conserved monomeric protein of about 200 amino acids. GK has been shown to be structurally similar to protein A57R (or SalG2R) from various strains of Vaccinia virus. Proteins containing one or more copies of the DHR domain, an SH3 domain as well as a C-terminal GK-like domain, are collectively termed MAGUKs (membrane-associated guanylate kinase homologs) and include Drosophila lethal(1)discs large-1 tumor suppressor protein (gene dlg1); mammalian tight junction protein Zo-1; a family of mammalian synaptic proteins that seem to interact with the cytoplasmic tail of NMDA receptor subunits (SAP90/PSD-95, CHAPSYN-110/PSD-93, SAP97/DLG1 and SAP102); vertebrate 55 kD erythrocyte membrane protein (p55); C. elegans protein lin-2; rat protein CASK; and human proteins DLG2 and DLG3. There is an ATP-binding site (P-loop) in the N-terminal section of GK, which is not conserved in the GK-like domain of the above proteins. However these proteins retain the residues known, in GK, to be involved in the binding of MP.

Immunogen :

GUK1 (AAH06249, 1 a.a. ~ 197 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-Dependent, Immunoprecipitation: Assay-Dependent, Western Blot: 1-5 µg/mL

Aliases :

AA409738; AL033299; AL033300; ATP:GMP phosphotransferase; ATP:GMP-phosphotransferase; AV026611; GMK; GMP kinase; GMPK; Guanylate kinase; guanylate kinase 1; GUK1; Guk-1; RP11-520H14.2