This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
IGF2R Monoclonal Antibody (MEM-238), Alexa Fluor 647
catalog :
MA5-18132
quantity :
100 Tests
price :
US 370.00
clonality :
monoclonal
host :
mouse
conjugate :
AF647
clone name :
MEM-238

The same clone is also sold as:
reactivity :
human
application :
western blot, flow cytometry
product information
Product Type :
Antibody
Product Name :
IGF2R Monoclonal Antibody (MEM-238), Alexa Fluor 647
Catalog # :
MA5-18132
Quantity :
100 Tests
Price :
US 370.00
Clonality :
Monoclonal
Purity :
Size-exclusion chromatography
Host :
Mouse
Reactivity :
Human, Non-human primate
Applications :
Flow Cytometry: 4 uLx100 uL whole blood or 10^6 cells, Western Blot: Assay-dependent
Species :
Human, Non-human primate
Clone :
MEM-238
Isotype :
IgG1
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
Lysosomal enzymes containing one or two mannose 6-phosphate (man6P) moieties are moved about in the cell by two distinct but interconnected cycles by means of approximately 300 kDa cation independent mannose 6-phospate receptors (CI-MPR). The biosynthetic cycle refers to the MPR transport of newly synthesized lysosomal enzymes from the trans Golgi network to late endosomes or early lysosomes. The endocytic cycle transports extracellular lysosomal enzymes from the plasma membrane via clathrin-coated vesicles to early endosomes. The entire pool of MPRs cycles between these cellular compartments every 3 hours. The steady state distribution of MPR's is predominantly within late endosomes, fewer in the trans Golgi network and approximately 10 % at cell surface. In addition to its man6P binding activity, the MPR contains a separate binding site for the type II insulin-like growth factor and is capable of binding both man6P and IGF-II simultaneously. An approximately 240 kDa soluble, truncated form, representing the extracellular domain of the protein, has also been found circulating in serum and is capable of binding both ligands.
Immunogen :
Recombinant Vaccinia virus encoding CD222
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 4 uLx100 uL whole blood or 10^6 cells, Western Blot: Assay-dependent
Aliases :
300 kDa mannose 6-phosphate receptor; AI661837; cation-independent mannose 6-phosphate receptor; cation-independent mannose 6-phosphate receptor protein; cation-independent mannose-6-phosphate receptor; cation-independent MPR; CD222; CI Man-6-P receptor; CI-M6PR; CIMPR; CI-MPR; Igf2r; IGF-II receptor; IGF-II/CI-MPR; Igfr2; insulin like growth factor 2 receptor; insulin-like growth factor 2 receptor; Insulin-like growth factor II receptor; insulin-like growth factor receptor type 2; M6P; M6P/IGF2 receptor; M6P/IGF2R; M6PR; M6P-R; mannose-6-phosphate receptor, cation independent; mannose-6-phosphate/insulin-like growth factor II receptor; MPR 300; MPR1; MPR300; MPRI; similar to mannose-6-phosphate/insulin-like growth factor II receptor
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA