CD34 Monoclonal Antibody (QBEND/10) | Invitrogen MA5-18091 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD34 Monoclonal Antibody (QBEND/10)

catalog :

MA5-18091

quantity :

100 µL

price :

US 582

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

QBEND/10

reactivity :

human, mouse, domestic rabbit

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 52

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human; 1:250; fig 5d	Hauke M, Eckenstaler R, Ripperger A, Ender A, Braun H, Benndorf R. Active RhoA Exerts an Inhibitory Effect on the Homeostasis and Angiogenic Capacity of Human Endothelial Cells. J Am Heart Assoc. 2022;11:e025119 pubmed publisher
immunohistochemistry - paraffin section; human; 1 ug/ml; loading ...; fig 4b	Fathy E, Shafiek H, Morsi T, El Sabaa B, Elnekidy A, Elhoffy M, et al. Image-enhanced bronchoscopic evaluation of bronchial mucosal microvasculature in COPD. Int J Chron Obstruct Pulmon Dis. 2016;11:2447-2455 pubmed
immunohistochemistry; human; 1:100; fig 1	Feng J, Zhu R, Chang C, Yu L, Cao F, Zhu G, et al. CK19 and Glypican 3 Expression Profiling in the Prognostic Indication for Patients with HCC after Surgical Resection. PLoS ONE. 2016;11:e0151501 pubmed publisher
immunohistochemistry - paraffin section; human; 1:100	Jung M, Ryu Y, Kang G. Investigation of the origin of stromal and endothelial cells at the desmoplastic interface in xenograft tumor in mice. Pathol Res Pract. 2015;211:925-30 pubmed publisher
immunohistochemistry - paraffin section; human; 1:50	Chen S, Wang W, Wang L, Lin Q, Zhao G, Xu G, et al. Glioneuronal tumours with features of rosette-forming glioneuronal tumours of the fourth ventricle and dysembryoplastic neuroepithelial tumours: a report of three cases. Histopathology. 2016;68:378-87 pubmed publisher
immunohistochemistry - paraffin section; human; 1:200	Li L, Fan X, Xia Q, Rao Q, Liu B, Yu B, et al. Concurrent loss of INI1, PBRM1, and BRM expression in epithelioid sarcoma: implications for the cocontributions of multiple SWI/SNF complex members to pathogenesis. Hum Pathol. 2014;45:2247-54 pubmed publisher
immunohistochemistry; human; 1:200	Tasli F, Vardar E, Argon A, Kabat T, Deniz S, Nart A, et al. Histochemical and immunohistochemical characteristics of elastofibromas. Pol J Pathol. 2014;65:120-4 pubmed
immunocytochemistry; human	Yuan S, Guo Y, Zhou X, Shen W, Chen H. PDGFR-? (+) perivascular cells from infantile hemangioma display the features of mesenchymal stem cells and show stronger adipogenic potential in vitro and in vivo. Int J Clin Exp Pathol. 2014;7:2861-70 pubmed
immunohistochemistry; human; 1:50	Altinay S, Kusaslan R. Gastrointestinal autonomic nerve tumour of jejunum presenting as a perforated mass. J Pak Med Assoc. 2014;64:461-4 pubmed
immunohistochemistry; human; 1:200	Muică Nagy Bota M, Pap Z, Dénes L, Ghizdavăţ A, Brînzaniuc K, Lup Coşarcă A, et al. Immunohistochemical study of Ki67, CD34 and p53 expression in human tooth buds. Rom J Morphol Embryol. 2014;55:43-8 pubmed
immunohistochemistry; human; 1:100	San Martin R, Barron D, Tuxhorn J, Ressler S, Hayward S, Shen X, et al. Recruitment of CD34(+) fibroblasts in tumor-associated reactive stroma: the reactive microvasculature hypothesis. Am J Pathol. 2014;184:1860-70 pubmed publisher
immunohistochemistry; human; 1:4000	Rizzardi A, Rosener N, Koopmeiners J, Isaksson Vogel R, Metzger G, Forster C, et al. Evaluation of protein biomarkers of prostate cancer aggressiveness. BMC Cancer. 2014;14:244 pubmed publisher
immunohistochemistry; domestic rabbit	Sevim K, Yazar M, Irmak F, Tekkesin M, Yildiz K, Sirvan S. Use of platelet-rich plasma solution applied with composite chondrocutaneous graft technique: an experimental study in rabbit model. J Oral Maxillofac Surg. 2014;72:1407-19 pubmed publisher
immunohistochemistry; human; 1:200	Benedek Lázár E, Köpeczi J, Tunyogi A, Kakucs E, Horváth E, Turcu M, et al. Histopathological, immunophenotypic and clinical particularities and evolution of a case of hepatosplenic T-cell lymphoma in transformation to leukemia. Rom J Morphol Embryol. 2013;54:1135-9 pubmed
immunohistochemistry; human; 1:400	Chang I, Hsu C, Lin J, Hung C. The prognostic impact of MGMT expression on low-grade gangliogliomas: a clinicopathological and immunohistochemical study. Folia Neuropathol. 2013;51:275-82 pubmed
immunohistochemistry; human; 1:400	Schaefer I, Strobel P, Cameron S, Beham A, Otto C, Schildhaus H, et al. Rhabdoid morphology in gastrointestinal stromal tumours (GISTs) is associated with PDGFRA mutations but does not imply aggressive behaviour. Histopathology. 2014;64:421-30 pubmed publisher
immunohistochemistry; mouse; 1:200; fig 4	Kawano K, Hattori Y, Iwakura H, Akamizu T, Maitani Y. Combination therapy with gefitinib and doxorubicin inhibits tumor growth in transgenic mice with adrenal neuroblastoma. Cancer Med. 2013;2:286-95 pubmed publisher
immunohistochemistry; human	D AMICO L, Patane S, Grange C, Bussolati B, Isella C, Fontani L, et al. Primary breast cancer stem-like cells metastasise to bone, switch phenotype and acquire a bone tropism signature. Br J Cancer. 2013;108:2525-36 pubmed publisher
immunohistochemistry; human; 1:50	Kara T, Serinsoz E, Arpaci R, Gubur O, Orekici G, Ata A, et al. Contribution of DOG1 expression to the diagnosis of gastrointestinal stromal tumors. Pathol Res Pract. 2013;209:413-7 pubmed publisher
immunohistochemistry; human	Witjes C, ten Kate F, Verhoef C, de Man R, Ijzermans J. Immunohistochemical characteristics of hepatocellular carcinoma in non-cirrhotic livers. J Clin Pathol. 2013;66:687-91 pubmed publisher
immunohistochemistry; human; 1:800	Shelekhova K, Calonje E, Grossmann P, Kacerovska D, Koudela K, Mirka H, et al. Superficial soft tissue biphasic synovial sarcoma with apocrine differentiation in the glandular component: a report of two cases. Am J Dermatopathol. 2014;36:847-52 pubmed publisher
immunohistochemistry; human; 1:30	Tiberio L, Nascimbeni R, Villanacci V, Casella C, Fra A, Vezzoli V, et al. The decrease of mineralcorticoid receptor drives angiogenic pathways in colorectal cancer. PLoS ONE. 2013;8:e59410 pubmed publisher
immunohistochemistry; human	Su T, Hwang M, Li C, Wang S, Lee C, Chen C. A rare malignant tumor of scalp in a 3-month-old Taiwanese infancy: case report of primitive myxoid mesenchymal tumor of infancy with molecular study. Med Mol Morphol. 2013;46:109-13 pubmed publisher
immunohistochemistry; human; 1:200	Calibasi G, Baskin Y, Alyuruk H, Cavas L, Oztop I, Sagol O, et al. Molecular analysis of the KIT gene in gastrointestinal stromal tumors with novel mutations. Appl Immunohistochem Mol Morphol. 2014;22:37-45 pubmed publisher
immunohistochemistry; human	Wu S, Yu L, Wang D, Zhou L, Cheng Z, Chai D, et al. Aberrant expression of CD133 in non-small cell lung cancer and its relationship to vasculogenic mimicry. BMC Cancer. 2012;12:535 pubmed publisher
immunohistochemistry; human; 1:500	Pardo J, Panizo A, Sola I, Queipo F, Martínez Peñuela A, Carias R. Prognostic value of clinical, morphologic, and immunohistochemical factors in patients with bronchiolitis obliterans-organizing pneumonia. Hum Pathol. 2013;44:718-24 pubmed publisher
immunohistochemistry; human	Pagano L, Valentini C, Pulsoni A, Fisogni S, Carluccio P, Mannelli F, et al. Blastic plasmacytoid dendritic cell neoplasm with leukemic presentation: an Italian multicenter study. Haematologica. 2013;98:239-46 pubmed publisher
immunohistochemistry; human; 1:100	Bartoloni G, Pucci A, Giorlandino A, Berretta M, Mignosa C, Italia F, et al. Incidental Epstein-Barr virus associated atypical lymphoid proliferation arising in a left atrial myxoma: a case of long survival without any postsurgical treatment and review of the literature. Cardiovasc Pathol. 2013;22:e5-10 pubmed publisher
immunohistochemistry; human; 1:1500	Kim H, Sung J, Park W, Kim Y. Gastrointestinal stromal tumors of the stomach with extensive calcification: report of two cases. Intern Med. 2012;51:2555-8 pubmed
immunohistochemistry; human	Zhou Z, Yu M, Yang S, Zhou J, Sun R, Yang G. Dural angioleiomyoma of the middle cranial fossa: a case report and review of the literature. Brain Tumor Pathol. 2013;30:117-21 pubmed publisher
immunohistochemistry; human; 1:100	Kandemir N, Barut F, Gun B, Tekin N, Keser S, Ozdamar S. Histopathological analysis of vesicular and bullous lesions in Kaposi sarcoma. Diagn Pathol. 2012;7:101 pubmed publisher
immunohistochemistry; human	Liu J, Su T, Shen K, Lin S, Wang H, Hsu J, et al. Vaginal superficial myofibroblastoma: a rare mesenchymal tumor of the lower female genital tract and a study of its association with viral infection. Med Mol Morphol. 2012;45:110-4 pubmed publisher
immunohistochemistry; human	Wallenfels I, Chlumska A. Vaginal myofibroblastoma with glands expressing mammary and prostatic antigens. Cesk Patol. 2012;48:40-3 pubmed
immunohistochemistry; human	Wu S, Yu L, Cheng Z, Song W, Zhou L, Tao Y. Expression of maspin in non-small cell lung cancer and its relationship to vasculogenic mimicry. J Huazhong Univ Sci Technolog Med Sci. 2012;32:346-352 pubmed publisher
immunohistochemistry; human; 1:100	Jiang J, Jin M, Suo J, Wang Y, He L, Cao X. Evaluation of malignancy using Ki-67, p53, EGFR and COX-2 expressions in gastrointestinal stromal tumors. World J Gastroenterol. 2012;18:2569-75 pubmed publisher
immunohistochemistry; human; 1:80	Yin W, Li J, Chan J. Sporadic haemangioblastoma of the kidney with rhabdoid features and focal CD10 expression: report of a case and literature review. Diagn Pathol. 2012;7:39 pubmed publisher
immunohistochemistry; human	Barut A, Barut F, Kandemir N, Aktunc E, Arikan I, Harma M, et al. Placental chorangiosis: the association with oxidative stress and angiogenesis. Gynecol Obstet Invest. 2012;73:141-51 pubmed publisher
immunohistochemistry; human; fig 6	Reuwer A, Nowak Sliwinska P, Mans L, van der Loos C, von der Thüsen J, Twickler M, et al. Functional consequences of prolactin signalling in endothelial cells: a potential link with angiogenesis in pathophysiology?. J Cell Mol Med. 2012;16:2035-48 pubmed publisher
immunohistochemistry; human; 2 ug/ml	Tomić T, Gustavsson H, Wang W, Jennbacken K, Welén K, Damber J. Castration resistant prostate cancer is associated with increased blood vessel stabilization and elevated levels of VEGF and Ang-2. Prostate. 2012;72:705-12 pubmed publisher
immunocytochemistry; human	Yuan S, Chen R, Shen W, Chen H, Zhou X. Mesenchymal stem cells in infantile hemangioma reside in the perivascular region. Pediatr Dev Pathol. 2012;15:5-12 pubmed publisher
immunohistochemistry - paraffin section; human	Petrilli G, Lorenzi L, Paracchini R, Ubiali A, Schumacher R, Cabassa P, et al. Epstein-Barr virus-associated adrenal smooth muscle tumors and disseminated diffuse large B-cell lymphoma in a child with common variable immunodeficiency: a case report and review of the literature. Int J Surg Pathol. 2014;22:712-21 pubmed publisher
immunohistochemistry - paraffin section; human; 1:400; tbl 3	Damiani S, Eusebi V, Peterse J. Malignant neoplasms infiltrating pseudoangiomatous' stromal hyperplasia of the breast: an unrecognized pathway of tumour spread. Histopathology. 2002;41:208-15 pubmed
flow cytometry; human	Greenberg A, Kerr W, Hammer D. Relationship between selectin-mediated rolling of hematopoietic stem and progenitor cells and progression in hematopoietic development. Blood. 2000;95:478-86 pubmed
	Ouhaddi Y, Charbonnier B, Porge J, Zhang Y, Garcia I, Gbureck U, et al. Development of Neovasculature in Axially Vascularized Calcium Phosphate Cement Scaffolds. J Funct Biomater. 2023;14: pubmed publisher
	Niu Y, Stadler F, Yang X, Deng F, Liu G, Xia H. HA-coated collagen nanofibers for urethral regeneration via in situ polarization of M2 macrophages. J Nanobiotechnology. 2021;19:283 pubmed publisher
	Cha M, Seo J, Kim H, Kim M, Yoon H, Jo S, et al. Early Changes in Rat Heart After High-Dose Irradiation: Implications for Antiarrhythmic Effects of Cardiac Radioablation. J Am Heart Assoc. 2021;10:e019072 pubmed publisher
	Webber B, Lonetree C, Kluesner M, Johnson M, Pomeroy E, Diers M, et al. Highly efficient multiplex human T cell engineering without double-strand breaks using Cas9 base editors. Nat Commun. 2019;10:5222 pubmed publisher
	Lane R, Femel J, Breazeale A, Loo C, Thibault G, Kaempf A, et al. IFNγ-activated dermal lymphatic vessels inhibit cytotoxic T cells in melanoma and inflamed skin. J Exp Med. 2018;215:3057-3074 pubmed publisher
	Dallinga M, Yetkin Arik B, Kayser R, Vogels I, Nowak Sliwinska P, Griffioen A, et al. IGF2 and IGF1R identified as novel tip cell genes in primary microvascular endothelial cell monolayers. Angiogenesis. 2018;21:823-836 pubmed publisher
	Chen Y, Jing J, Mo Y, Ma J, Yang L, Chen L, et al. Presence of hepatitis B virus in synovium and its clinical significance in rheumatoid arthritis. Arthritis Res Ther. 2018;20:130 pubmed publisher
	Alessandrini L, Clemente N, Perin T, Giorda G, Canzonieri V, Sopracordevole F. Extramammary Paget disease of the vulva: immunohistochemical analysis of neoangiogenesis and epithelial-mesenchymal transition markers expression. Diagn Pathol. 2018;13:2 pubmed publisher
	Koumarianou A, Economopoulou P, Katsaounis P, Laschos K, Arapantoni Dadioti P, Martikos G, et al. Gastrointestinal Stromal Tumors (GIST): A Prospective Analysis and an Update on Biomarkers and Current Treatment Concepts. Biomark Cancer. 2015;7:1-7 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD34 Monoclonal Antibody (QBEND/10)

Catalog # :

MA5-18091

Quantity :

100 µL

Price :

US 582

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human, Non-human primate

Applications :

Flow Cytometry: 1:50, Immunohistochemistry (Frozen): Assay-dependent, Immunohistochemistry (Paraffin): 1:50-1:100, Immunoprecipitation: Assay-dependent, Western Blot: 1:1,000

Species :

Human, Non-human primate

Clone :

QBEND/10

Isotype :

IgG1

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Description :

CD34 is a highly glycosylated monomeric with a molecular weight range of 111-115 kDa surface protein that is present on many stem cell populations. CD34 is a stem cell marker although its expression on human hematopoietic stem cells is reversible. CD34 may serve as a surface receptor that undergoes receptor-mediated endocytosis and regulates adhesion, differentiation and proliferation of hematopoietic stem cells and other progenitors. CD34 expression is likely to represent a specific state of hematopoietic development that may have altered adhering properties with expanding and differentiating capabilities in both in vitro and in vivo conditions. CD34 is possibly an adhesion molecule with a putative role for mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Further, CD34 could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. CD34 is thought to have a role in presenting carbohydrate ligands to selectins. The intracellular chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C suggesting a putative role in signal transduction. Diseases associated with CD34 dysfunction include dermatofibrosarcoma and neurofibroma.

Immunogen :

Human endothelial vesicles

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1:50, Immunohistochemistry (Frozen): Assay-dependent, Immunohistochemistry (Paraffin): 1:50-1:100, Immunoprecipitation: Assay-dependent, Western Blot: 1:1,000

Aliases :

(E3-independent) E2 ubiquitin-conjugating enzyme R1; AU040960; CD34; CD34 antigen; CD34 molecule; CDC34; cell division cycle 34; cell division cycle 34 homolog; cluster designation 34; cluster of differentiation antigen 34; E2 ubiquitin-conjugating enzyme R1; E2-CDC34; hematopoietic progenitor cell antigen CD34; hematopoietic progenitor cell marker CD34; Mucosialin; RP11-328D5.2; sialomucin protein; type 1 transmembrane protein; UBC3; UBCH3; UBE2R1; ubiquitin carrier protein; ubiquitin conjugating enzyme E2 R1; ubiquitin-conjugating enzyme E2 R1; Ubiquitin-conjugating enzyme E2-32 kDa complementing; ubiquitin-conjugating enzyme E2-CDC34; Ubiquitin-protein ligase R1

more info or order :

Invitrogen product webpage