Nesprin 1 Monoclonal Antibody (MANNES1A(7A12)) | Invitrogen MA5-18077 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Nesprin 1 Monoclonal Antibody (MANNES1A(7A12))

catalog :

MA5-18077

quantity :

100 µL

price :

US 586

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

MANNES1A(7A12)

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry

more info or order :

Invitrogen product webpage

citations: 8

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human; loading ...; fig 5b western blot; human; 1:500; loading ...; fig 6a	Svobodová Kovaříková A, Bartova E, Kovarik A, Lukasova E. Spatiotemporal Mislocalization of Nuclear Membrane-Associated Proteins in γ-Irradiation-Induced Senescent Cells. Cells. 2020;9: pubmed publisher
immunocytochemistry; human; 1:50; loading ...; fig 2c	Hatch E, Hetzer M. Nuclear envelope rupture is induced by actin-based nucleus confinement. J Cell Biol. 2016;215:27-36 pubmed
	Sharma R, Hetzer M. Disulfide bond in SUN2 regulates dynamic remodeling of LINC complexes at the nuclear envelope. Life Sci Alliance. 2023;6: pubmed publisher
	Ulloa R, Corrales O, Cabrera Reyes F, Jara Wilde J, Saez J, Rivas C, et al. B Cells Adapt Their Nuclear Morphology to Organize the Immune Synapse and Facilitate Antigen Extraction. Front Immunol. 2021;12:801164 pubmed publisher
	Denis K, Cabe J, Danielsson B, Tieu K, Mayer C, Conway D. The LINC complex is required for endothelial cell adhesion and adaptation to shear stress and cyclic stretch. Mol Biol Cell. 2021;:mbcE20110698 pubmed publisher
	Yi X, Wright L, Pagnotti G, Uzer G, Powell K, Wallace J, et al. Mechanical suppression of breast cancer cell invasion and paracrine signaling to osteoclasts requires nucleo-cytoskeletal connectivity. Bone Res. 2020;8:40 pubmed publisher
	Nastały P, Purushothaman D, Marchesi S, Poli A, Lendenmann T, Kidiyoor G, et al. Role of the nuclear membrane protein Emerin in front-rear polarity of the nucleus. Nat Commun. 2020;11:2122 pubmed publisher
	Bersini S, Lytle N, Schulte R, Huang L, Wahl G, Hetzer M. Nup93 regulates breast tumor growth by modulating cell proliferation and actin cytoskeleton remodeling. Life Sci Alliance. 2020;3: pubmed publisher

product information

Product Type :

Antibody

Product Name :

Nesprin 1 Monoclonal Antibody (MANNES1A(7A12))

Catalog # :

MA5-18077

Quantity :

100 µL

Price :

US 586

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human, Mouse, Rabbit, Rat

Applications :

Immunocytochemistry: 1:200, Western Blot: 1:400-1:800

Species :

Human, Mouse, Rabbit, Rat

Clone :

MANNES1A(7A12)

Isotype :

IgG1

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Description :

There are two genes encoding members of a new family of type II integral membrane proteins. Both are ubiquitously expressed, and tissue-specific alternative mRNA initiation and splicing generate at least two major isoforms of each protein, with the smaller isoforms being truncated at the N-terminus. These proteins are called nesprin-l and -2 for nuclear _envelope _spectrin repeat, as they are characterized by the presence of multiple, clustered spectrin repeats, bipartite nuclear localization sequences and a conserved C-terminal, single transmembrane domain. Transient transfection of EGFP-fusion expression constructs demonstrated their localization to the nuclear membrane with a novel C-terminal, TM-domain-containing sequence essential for perinuclear localization. Nesprin-l is developmentally regulated in both smooth and skeletal muscle and is relocalized from the nuclear envelope to the nucleus and cytoplasm during C2Cl2 myoblast differentiation. Nesprins may function as 'dystrophins of the nucleus' to maintain nuclear organization and structura integrity.

Immunogen :

Recombinant full length Nesprin 1(Human)

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:200, Western Blot: 1:400-1:800

Aliases :

8B; A330049M09Rik; ARCA1; BE692247; C130039F11Rik; C6orf98; CPG2; CPG2 full length; dJ45H2.2; DKFZp781J13156; EDMD4; enaptin; enaptin165; FLJ30878; FLJ41140; KASH domain-containing protein 1; KASH1; KIAA0796; KIAA1262; KIAA1756; mKIAA1756; MYNE1; Myne-1; Myocyte nuclear envelope protein 1; Nesp1; nesprin 1; nesprin-1; Nuclear envelope spectrin repeat protein 1; RP1-130E4.2; SCAR8; spectrin repeat containing nuclear envelope protein 1; spectrin repeat containing, nuclear envelope 1; synaptic nuclear envelope 1; synaptic nuclear envelope protein 1; synaptic nuclei expressed gene 1; SYNE 1; SYNE1; Syne-1; syne-1 fragment

more info or order :

Invitrogen product webpage