CD11b Monoclonal Antibody (M1/70.15) | Invitrogen MA5-17857 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD11b Monoclonal Antibody (M1/70.15)

catalog :

MA5-17857

quantity :

250 ug

price :

US 292.00

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

M1/70.15

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, other

more info or order :

Invitrogen product webpage

citations: 82

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse	Bohannon C, Ende Z, Cao W, Mboko W, Ranjan P, Kumar A, et al. Influenza Virus Infects and Depletes Activated Adaptive Immune Responders. Adv Sci (Weinh). 2021;8:e2100693 pubmed publisher
immunohistochemistry; mouse; 1:400; loading ...; fig 1a	Niu H, Wang Q, Zhao W, Liu J, Wang D, Muhammad B, et al. IL-1β/IL-1R1 signaling induced by intranasal lipopolysaccharide infusion regulates alpha-Synuclein pathology in the olfactory bulb, substantia nigra and striatum. Brain Pathol. 2020;30:1102-1118 pubmed publisher
immunohistochemistry - frozen section; mouse; 1:1000; fig 4b	Klein J, Moses K, Zelinskyy G, Sody S, Buer J, Lang S, et al. Combined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth. Nat Commun. 2017;8:14600 pubmed publisher
flow cytometry; mouse; fig 1	Kaplan J, Marshall M, C McSkimming C, Harmon D, Garmey J, Oldham S, et al. Adipocyte progenitor cells initiate monocyte chemoattractant protein-1-mediated macrophage accumulation in visceral adipose tissue. Mol Metab. 2015;4:779-94 pubmed publisher
flow cytometry; human; 1:200; fig 4	Stasulli N, Eichelberger K, Price P, Pechous R, Montgomery S, Parker J, et al. Spatially distinct neutrophil responses within the inflammatory lesions of pneumonic plague. MBio. 2015;6:e01530-15 pubmed publisher
flow cytometry; mouse; 1:500; fig 4	Pechous R, Broberg C, Stasulli N, Miller V, Goldman W. In vivo transcriptional profiling of Yersinia pestis reveals a novel bacterial mediator of pulmonary inflammation. MBio. 2015;6:e02302-14 pubmed publisher
flow cytometry; mouse	DÃ¶ring M, Lessin I, Frenz T, Spanier J, Kessler A, Tegtmeyer P, et al. M27 expressed by cytomegalovirus counteracts effective type I interferon induction of myeloid cells but not of plasmacytoid dendritic cells. J Virol. 2014;88:13638-50 pubmed publisher
flow cytometry; mouse; fig s2	Pechous R, Sivaraman V, Price P, Stasulli N, Goldman W. Early host cell targets of Yersinia pestis during primary pneumonic plague. PLoS Pathog. 2013;9:e1003679 pubmed publisher
flow cytometry; mouse; tbl 2	Mandal M, Donnelly R, Elkabes S, Zhang P, Davini D, David B, et al. Maternal immune stimulation during pregnancy shapes the immunological phenotype of offspring. Brain Behav Immun. 2013;33:33-45 pubmed publisher
flow cytometry; mouse; fig 2	Zurita E, Moreno G, Errea A, Ormazabal M, Rumbo M, Hozbor D. The stimulated innate resistance event in Bordetella pertussis infection is dependent on reactive oxygen species production. Infect Immun. 2013;81:2371-8 pubmed publisher
immunocytochemistry; mouse; fig 3	Mills J, Kim D, Krenz A, Chen J, Bynoe M. A2A adenosine receptor signaling in lymphocytes and the central nervous system regulates inflammation during experimental autoimmune encephalomyelitis. J Immunol. 2012;188:5713-22 pubmed publisher
flow cytometry; mouse	Mathieu M, Cotta Grand N, Daudelin J, Boulet S, Lapointe R, Labrecque N. CD40-activated B cells can efficiently prime antigen-specific naïve CD8+ T cells to generate effector but not memory T cells. PLoS ONE. 2012;7:e30139 pubmed publisher
flow cytometry; mouse; fig 2	Haworth O, Cernadas M, Levy B. NK cells are effectors for resolvin E1 in the timely resolution of allergic airway inflammation. J Immunol. 2011;186:6129-35 pubmed publisher
flow cytometry; mouse	Solodova E, Jablonska J, Weiss S, Lienenklaus S. Production of IFN-? during Listeria monocytogenes infection is restricted to monocyte/macrophage lineage. PLoS ONE. 2011;6:e18543 pubmed publisher
flow cytometry; mouse; fig 5	Asensio C, Gaillard M, Moreno G, Bottero D, Zurita E, Rumbo M, et al. Outer membrane vesicles obtained from Bordetella pertussis Tohama expressing the lipid A deacylase PagL as a novel acellular vaccine candidate. Vaccine. 2011;29:1649-56 pubmed publisher
flow cytometry; mouse; fig 1	Zumsteg A, Baeriswyl V, Imaizumi N, Schwendener R, Ruegg C, Christofori G. Myeloid cells contribute to tumor lymphangiogenesis. PLoS ONE. 2009;4:e7067 pubmed publisher
flow cytometry; mouse	Siegemund S, Hartl A, von Buttlar H, Dautel F, Raue R, Freudenberg M, et al. Conventional bone marrow-derived dendritic cells contribute to toll-like receptor-independent production of alpha/beta interferon in response to inactivated parapoxvirus ovis. J Virol. 2009;83:9411-22 pubmed publisher
flow cytometry; mouse	Velaga S, Herbrand H, Friedrichsen M, Jiong T, Dorsch M, Hoffmann M, et al. Chemokine receptor CXCR5 supports solitary intestinal lymphoid tissue formation, B cell homing, and induction of intestinal IgA responses. J Immunol. 2009;182:2610-9 pubmed publisher
flow cytometry; mouse; fig 2, 4	Rogers N, Lees M, Gabriel L, Maniati E, Rose S, Potter P, et al. A defect in Marco expression contributes to systemic lupus erythematosus development via failure to clear apoptotic cells. J Immunol. 2009;182:1982-90 pubmed publisher
flow cytometry; mouse	Muller U, Stenzel W, Kohler G, Polte T, Blessing M, Mann A, et al. A gene-dosage effect for interleukin-4 receptor alpha-chain expression has an impact on Th2-mediated allergic inflammation during bronchopulmonary mycosis. J Infect Dis. 2008;198:1714-21 pubmed publisher
immunohistochemistry - frozen section; mouse	Fukushima A, Sumi T, Ishida W, Yamada J, Iwakura Y, Ueno H. Endogenous IL-17 does not play a significant role in the development of experimental murine allergic conjunctivitis. Int Arch Allergy Immunol. 2008;147:206-12 pubmed publisher
flow cytometry; mouse; fig 1	Ikehara Y, Shiuchi N, Kabata Ikehara S, Nakanishi H, Yokoyama N, Takagi H, et al. Effective induction of anti-tumor immune responses with oligomannose-coated liposome targeting to intraperitoneal phagocytic cells. Cancer Lett. 2008;260:137-45 pubmed
flow cytometry; mouse	Muller U, Stenzel W, Kohler G, Werner C, Polte T, Hansen G, et al. IL-13 induces disease-promoting type 2 cytokines, alternatively activated macrophages and allergic inflammation during pulmonary infection of mice with Cryptococcus neoformans. J Immunol. 2007;179:5367-77 pubmed
flow cytometry; mouse	Chen H, ORDOG T, Chen J, YOUNG D, Bardsley M, Redelman D, et al. Differential gene expression in functional classes of interstitial cells of Cajal in murine small intestine. Physiol Genomics. 2007;31:492-509 pubmed
flow cytometry; mouse; fig 2	Noel G, Guo X, Wang Q, Schwemberger S, Byrum D, Ogle C. Postburn monocytes are the major producers of TNF-alpha in the heterogeneous splenic macrophage population. Shock. 2007;27:312-9 pubmed
flow cytometry; mouse	Chen H, Redelman D, Ro S, Ward S, ORDOG T, Sanders K. Selective labeling and isolation of functional classes of interstitial cells of Cajal of human and murine small intestine. Am J Physiol Cell Physiol. 2007;292:C497-507 pubmed
flow cytometry; mouse	Sudres M, Norol F, Trenado A, Gregoire S, Charlotte F, Levacher B, et al. Bone marrow mesenchymal stem cells suppress lymphocyte proliferation in vitro but fail to prevent graft-versus-host disease in mice. J Immunol. 2006;176:7761-7 pubmed
flow cytometry; mouse	Silver K, Ferry H, Crockford T, Cornall R. TLR4, TLR9 and MyD88 are not required for the positive selection of autoreactive B cells into the primary repertoire. Eur J Immunol. 2006;36:1404-12 pubmed
flow cytometry; mouse; fig 7	Haque A, Easton A, Smith D, O GARRA A, Van Rooijen N, Lertmemongkolchai G, et al. Role of T cells in innate and adaptive immunity against murine Burkholderia pseudomallei infection. J Infect Dis. 2006;193:370-9 pubmed
flow cytometry; mouse; fig 4	Grisaru D, Pick M, Perry C, Sklan E, Almog R, Goldberg I, et al. Hydrolytic and nonenzymatic functions of acetylcholinesterase comodulate hemopoietic stress responses. J Immunol. 2006;176:27-35 pubmed
immunohistochemistry - frozen section; mouse; fig 1f	Sato K, Komatsu N, Higashi N, Imai Y, Irimura T. Granulation tissue formation by nonspecific inflammatory agent occurs independently of macrophage galactose-type C-type lectin-1. Clin Immunol. 2005;115:47-50 pubmed
flow cytometry; mouse	Gomariz R, Arranz A, Abad C, Torroba M, Martinez C, Rosignoli F, et al. Time-course expression of Toll-like receptors 2 and 4 in inflammatory bowel disease and homeostatic effect of VIP. J Leukoc Biol. 2005;78:491-502 pubmed
other; mouse; 1:10 flow cytometry; mouse; 1:10	Sato K, Imai Y, Higashi N, Kumamoto Y, Mukaida N, Irimura T. Redistributions of macrophages expressing the macrophage galactose-type C-type lectin (MGL) during antigen-induced chronic granulation tissue formation. Int Immunol. 2005;17:559-68 pubmed
flow cytometry; mouse; 1 ug/ml	Sato K, Imai Y, Higashi N, Kumamoto Y, Onami T, Hedrick S, et al. Lack of antigen-specific tissue remodeling in mice deficient in the macrophage galactose-type calcium-type lectin 1/CD301a. Blood. 2005;106:207-15 pubmed
flow cytometry; mouse; fig 1b	Cavassani K, Aliberti J, Dias A, Silva J, Ferreira B. Tick saliva inhibits differentiation, maturation and function of murine bone-marrow-derived dendritic cells. Immunology. 2005;114:235-45 pubmed
immunohistochemistry; mouse; fig 4	Wang T, Town T, Alexopoulou L, Anderson J, Fikrig E, Flavell R. Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis. Nat Med. 2004;10:1366-73 pubmed
flow cytometry; mouse; 4 ug/ml; fig 2	ORDOG T, Redelman D, Horváth V, Miller L, Horowitz B, Sanders K. Quantitative analysis by flow cytometry of interstitial cells of Cajal, pacemakers, and mediators of neurotransmission in the gastrointestinal tract. Cytometry A. 2004;62:139-49 pubmed
flow cytometry; mouse	Zheng S, Jiang J, Shen H, Chen Y. Reduced apoptosis and ameliorated listeriosis in TRAIL-null mice. J Immunol. 2004;173:5652-8 pubmed
flow cytometry; mouse; fig 4	Mattner J, Wandersee Steinhäuser A, Pahl A, Rollinghoff M, Majeau G, Hochman P, et al. Protection against progressive leishmaniasis by IFN-beta. J Immunol. 2004;172:7574-82 pubmed
flow cytometry; mouse; fig 4	Yuan Y, Shen H, Franklin D, Scadden D, Cheng T. In vivo self-renewing divisions of haematopoietic stem cells are increased in the absence of the early G1-phase inhibitor, p18INK4C. Nat Cell Biol. 2004;6:436-42 pubmed
flow cytometry; mouse; fig 1	Dogusan Z, Montecino Rodriguez E, Dorshkind K. Macrophages and stromal cells phagocytose apoptotic bone marrow-derived B lineage cells. J Immunol. 2004;172:4717-23 pubmed
flow cytometry; mouse; fig 5	Ohse T, Ota T, Kieran N, Godson C, Yamada K, Tanaka T, et al. Modulation of interferon-induced genes by lipoxin analogue in anti-glomerular basement membrane nephritis. J Am Soc Nephrol. 2004;15:919-27 pubmed
flow cytometry; mouse; fig 6	Schleicher U, Mattner J, Blos M, Schindler H, Rollinghoff M, Karaghiosoff M, et al. Control of Leishmania major in the absence of Tyk2 kinase. Eur J Immunol. 2004;34:519-29 pubmed
immunohistochemistry; mouse; fig 3	Ozaki A, Ishida W, Fukata K, Fukushima A, Ueno H. Detection of antigen-specific T cells in experimental immune-mediated blepharoconjunctivitis in DO11.10 T cell receptor transgenic mice. Microbiol Immunol. 2004;48:39-48 pubmed
flow cytometry; mouse; fig 3	ORDOG T, Redelman D, Miller L, Horváth V, Zhong Q, Almeida Porada G, et al. Purification of interstitial cells of Cajal by fluorescence-activated cell sorting. Am J Physiol Cell Physiol. 2004;286:C448-56 pubmed
flow cytometry; mouse; fig 3	Morin J, Chimènes A, Boitard C, Berthier R, Boudaly S. Granulocyte-dendritic cell unbalance in the non-obese diabetic mice. Cell Immunol. 2003;223:13-25 pubmed
flow cytometry; mouse; fig 6, 7	Blos M, Schleicher U, Soares Rocha F, Meissner U, Rollinghoff M, Bogdan C. Organ-specific and stage-dependent control of Leishmania major infection by inducible nitric oxide synthase and phagocyte NADPH oxidase. Eur J Immunol. 2003;33:1224-34 pubmed
flow cytometry; mouse	Gilbert K, Boger S, Fifer E. Butyric acid derivative induces allospecific T cell anergy and prevents graft-versus-host disease. Immunopharmacol Immunotoxicol. 2003;25:13-27 pubmed
flow cytometry; mouse; fig 3	Roach D, Bean A, Demangel C, France M, Briscoe H, Britton W. TNF regulates chemokine induction essential for cell recruitment, granuloma formation, and clearance of mycobacterial infection. J Immunol. 2002;168:4620-7 pubmed
flow cytometry; mouse	Simmons W, Simms M, Chiarle R, Mackay F, Tsiagbe V, Browning J, et al. Induction of germinal centers by MMTV encoded superantigen on B cells. Dev Immunol. 2001;8:201-11 pubmed
flow cytometry; mouse; fig 8	Saio M, Radoja S, Marino M, Frey A. Tumor-infiltrating macrophages induce apoptosis in activated CD8(+) T cells by a mechanism requiring cell contact and mediated by both the cell-associated form of TNF and nitric oxide. J Immunol. 2001;167:5583-93 pubmed
immunohistochemistry - frozen section; mouse; 1 ug/ml	Matsuoka Y, Picciano M, Malester B, LaFrancois J, Zehr C, Daeschner J, et al. Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer's disease. Am J Pathol. 2001;158:1345-54 pubmed
flow cytometry; mouse	Panus J, McHeyzer Williams L, McHeyzer Williams M. Antigen-specific T helper cell function: differential cytokine expression in primary and memory responses. J Exp Med. 2000;192:1301-16 pubmed
flow cytometry; mouse; fig 4	Heisterkamp N, Voncken J, Senadheera D, Gonzalez Gomez I, Reichert A, Haataja L, et al. Reduced oncogenicity of p190 Bcr/Abl F-actin-binding domain mutants. Blood. 2000;96:2226-32 pubmed
flow cytometry; mouse	Rodewald H, Brocker T, Haller C. Developmental dissociation of thymic dendritic cell and thymocyte lineages revealed in growth factor receptor mutant mice. Proc Natl Acad Sci U S A. 1999;96:15068-73 pubmed
flow cytometry; mouse	Mikszta J, McHeyzer Williams L, McHeyzer Williams M. Antigen-driven selection of TCR In vivo: related TCR alpha-chains pair with diverse TCR beta-chains. J Immunol. 1999;163:5978-88 pubmed
flow cytometry; mouse; tbl 4	Saitoh T, Morimoto K, Kumagai T, Tsuboi I, Aikawa S, Horie T. Comparison of erythropoietic response to androgen in young and old senescence accelerated mice. Mech Ageing Dev. 1999;109:125-39 pubmed
flow cytometry; mouse; fig 3	Shepherd D, Kerkvliet N. Disruption of CD154:CD40 blocks generation of allograft immunity without affecting APC activation. J Immunol. 1999;163:2470-7 pubmed
flow cytometry; mouse	Penttilä J, Anttila M, Varkila K, Puolakkainen M, Sarvas M, Makela P, et al. Depletion of CD8+ cells abolishes memory in acquired immunity against Chlamydia pneumoniae in BALB/c mice. Immunology. 1999;97:490-6 pubmed
flow cytometry; mouse	McHeyzer Williams L, Panus J, Mikszta J, McHeyzer Williams M. Evolution of antigen-specific T cell receptors in vivo: preimmune and antigen-driven selection of preferred complementarity-determining region 3 (CDR3) motifs. J Exp Med. 1999;189:1823-38 pubmed
flow cytometry; mouse; fig 4	Contractor N, Bassiri H, Reya T, Park A, Baumgart D, Wasik M, et al. Lymphoid hyperplasia, autoimmunity, and compromised intestinal intraepithelial lymphocyte development in colitis-free gnotobiotic IL-2-deficient mice. J Immunol. 1998;160:385-94 pubmed
flow cytometry; mouse	Reya T, Contractor N, Couzens M, Wasik M, Emerson S, Carding S. Abnormal myelocytic cell development in interleukin-2 (IL-2)-deficient mice: evidence for the involvement of IL-2 in myelopoiesis. Blood. 1998;91:2935-47 pubmed
flow cytometry; mouse; fig 4	Postel Vinay M, de Mello Coelho V, Gagnerault M, Dardenne M. Growth hormone stimulates the proliferation of activated mouse T lymphocytes. Endocrinology. 1997;138:1816-20 pubmed
flow cytometry; mouse; fig 1	Lin K, Abraham K. Targets of p56(lck) activity in immature thymoblasts: stimulation of the Ras/Raf/MAPK pathway. Int Immunol. 1997;9:291-306 pubmed
immunoprecipitation; mouse	Goodell M, Brose K, Paradis G, Conner A, Mulligan R. Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo. J Exp Med. 1996;183:1797-806 pubmed
flow cytometry; mouse	Voncken J, Kaartinen V, Pattengale P, Germeraad W, Groffen J, Heisterkamp N. BCR/ABL P210 and P190 cause distinct leukemia in transgenic mice. Blood. 1995;86:4603-11 pubmed
flow cytometry; mouse	Horio F, Fukuda M, Katoh H, Petruzzelli M, Yano N, Rittershaus C, et al. Reactive oxygen intermediates in autoimmune islet cell destruction of the NOD mouse induced by peritoneal exudate cells (rich in macrophages) but not T cells. Diabetologia. 1994;37:22-31 pubmed
flow cytometry; mouse	Shinomiya N, Tsuru S, Katsura Y, Kayashima S, Nomoto K. Enhanced resistance against Listeria monocytogenes achieved by pretreatment with granulocyte colony-stimulating factor. Infect Immun. 1991;59:4740-3 pubmed
immunohistochemistry - paraffin section; mouse; 1:100	Cole G, Saha K, Seshan K, Lynn K, Franco M, Wong P. Retrovirus-induced immunodeficiency in mice exacerbates gastrointestinal candidiasis. Infect Immun. 1992;60:4168-78 pubmed
other; mouse flow cytometry; mouse immunoprecipitation; mouse	Springer T, Galfre G, Secher D, Milstein C. Mac-1: a macrophage differentiation antigen identified by monoclonal antibody. Eur J Immunol. 1979;9:301-6 pubmed
other; mouse; tbl 1	Springer T, Galfre G, Secher D, Milstein C. Monoclonal xenogeneic antibodies to murine cell surface antigens: identification of novel leukocyte differentiation antigens. Eur J Immunol. 1978;8:539-51 pubmed
	Muhammad B, Li H, Gu Y, Xue S, Gao Y, Xu Z, et al. IL-1β/IL-1R1 signaling is involved in the propagation of α-synuclein pathology of the gastrointestinal tract to the brain. J Neurochem. 2023;166:830-846 pubmed publisher
	Nascimento Da Conceicao V, Sun Y, Ramachandran K, Chauhan A, Raveendran A, Venkatesan M, et al. Resolving macrophage polarization through distinct Ca2+ entry channel that maintains intracellular signaling and mitochondrial bioenergetics. iScience. 2021;24:103339 pubmed publisher
	Candas Green D, Xie B, Huang J, Fan M, Wang A, Menaa C, et al. Dual blockade of CD47 and HER2 eliminates radioresistant breast cancer cells. Nat Commun. 2020;11:4591 pubmed publisher
	Clark P, Sriramaneni R, Jin W, Jagodinsky J, Bates A, Jaquish A, et al. In situ vaccination at a peripheral tumor site augments response against melanoma brain metastases. J Immunother Cancer. 2020;8: pubmed publisher
	Simon N, Antignani A, Hewitt S, Gadina M, Alewine C, Fitzgerald D. Tofacitinib enhances delivery of antibody-based therapeutics to tumor cells through modulation of inflammatory cells. JCI Insight. 2019;4: pubmed publisher
	Taghavie Moghadam P, Waseem T, Hattler J, Glenn L, Dobrian A, Kaplan M, et al. STAT4 Regulates the CD8+ Regulatory T Cell/T Follicular Helper Cell Axis and Promotes Atherogenesis in Insulin-Resistant Ldlr-/- Mice. J Immunol. 2017;199:3453-3465 pubmed publisher
	Peterson L, Philip N, DeLaney A, Wynosky Dolfi M, Asklof K, Gray F, et al. RIPK1-dependent apoptosis bypasses pathogen blockade of innate signaling to promote immune defense. J Exp Med. 2017;214:3171-3182 pubmed publisher
	Liu X, Jiang X, Liu R, Wang L, Qian T, Zheng Y, et al. B cells expressing CD11b effectively inhibit CD4+ T-cell responses and ameliorate experimental autoimmune hepatitis in mice. Hepatology. 2015;62:1563-75 pubmed publisher
	Ma C, Kapanadze T, Gamrekelashvili J, Manns M, Korangy F, Greten T. Anti-Gr-1 antibody depletion fails to eliminate hepatic myeloid-derived suppressor cells in tumor-bearing mice. J Leukoc Biol. 2012;92:1199-206 pubmed publisher
	Obst R, van Santen H, Mathis D, Benoist C. Antigen persistence is required throughout the expansion phase of a CD4(+) T cell response. J Exp Med. 2005;201:1555-65 pubmed
	Rodewald H, Waskow C, Haller C. Essential requirement for c-kit and common gamma chain in thymocyte development cannot be overruled by enforced expression of Bcl-2. J Exp Med. 2001;193:1431-7 pubmed

product information

Product Type :

Antibody

Product Name :

CD11b Monoclonal Antibody (M1/70.15)

Catalog # :

MA5-17857

Quantity :

250 ug

Price :

US 292.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.1 ug/1x10^6 cells, Functional Assay: Assay-dependent, Immunohistochemistry (Frozen): Assay-dependent, Immunohistochemistry (Paraffin): Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: Assay-dependent

Species :

Mouse

Clone :

M1/70.15

Isotype :

IgG2b

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

CD11b (integrin alpha-M, ITGAM, integrin alpha-X, ITGAX) is a 165 kDa adhesion molecule that associates non-covalently with integrin beta-2 (CD18). The CD11b/CD18 heterodimeric complex is also known as integrin alpha-M beta-2, Mac-1, and CR3 (complement receptor 3). CD11b is expressed on the surface of monocytes/macrophages, granulocytes, activated lymphocytes, a subset of NK cells, a subset of dendritic cells, and microglia in the brain. CD11b/CD18 functions as the receptor for ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), CD14, CD50, CD23, heparin, iC3b, fibrinogen, and Factor X -these adhesions are critical for cell-cell and cell-matrix interactions. CD11b is expressed on 8% of spleen cells, 44% of bone marrow cells, and less than 1% of thymocytes, and is commonly used as a microglial marker in nervous tissue. The expression of CD11b increases during monocyte maturation and expression levels vary on tissue macrophages. Further, peritoneal macrophages are reported to express higher levels of CD11b than splenic macrophages. Diseases associated with CD11b dysfunction include systemic lupus erythematosus 6 and ITGAM-related susceptibility to systemic lupus erythematosus.

Immunogen :

C57BL/6 spleen cell enriched for T lymphocytes

Format :

Liquid

Applications w/Dilutions :

Aliases :

antigen CD11b (p170); antigen CD11b (p170); macrophage antigen alpha polypeptide; CD11 antigen-like family member B; CD11b; CD11B (p170); CD11b/CD18; cell surface glycoprotein MAC-1 alpha subunit; cell surface glycoprotein MAC-1 subunit alpha; complement component 3 receptor 3 subunit; complement component receptor 3 alpha-a; complement receptor type 3; CR3; CR-3 alpha chain; CR3A; F730045J24Rik; integrin alpha M; integrin alpha-M; integrin subunit alpha M; integrin, alpha M; integrin, alpha M (complement component 3 receptor 3 subunit); ITGAM; Leukocyte adhesion receptor MO1; leukocyte integrin alpha-M chain; LOC100351865; Ly-40; MAC1; Mac-1; Mac-1 alpha; Mac-1 alpha (Mac1A); MAC-1 alpha subunit; MAC1A; Mac-1a; macrophage antigen alpha; macrophage antigen alpha polypeptide; MGC117044; MO1A; Neutrophil adherence receptor; neutrophil adherence receptor alpha-M subunit; SLEB6; unnamed protein product

more info or order :

Invitrogen product webpage