I-Ap Monoclonal Antibody (7-16.17), FITC | Invitrogen MA5-17769 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

I-Ap Monoclonal Antibody (7-16.17), FITC

catalog :

MA5-17769

quantity :

100 µg

price :

US 239

clonality :

monoclonal

host :

mouse

conjugate :

FITC

clone name :

7-16.17

reactivity :

mouse

application :

flow cytometry

product information

Product Type :

Antibody

Product Name :

I-Ap Monoclonal Antibody (7-16.17), FITC

Catalog # :

MA5-17769

Quantity :

100 µg

Price :

US 239

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.5 µg/1x10^6 cells

Species :

Mouse

Clone :

7-16.17

Isotype :

IgG2a

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark.

Description :

MHC Class II (I-Ap) is a protein complex found on the surface of cells in vertebrates. Its main function is to present peptides derived from extracellular proteins to T cells for immune recognition. MHC Class II (I-Ap) is composed of an alpha and beta chain, both of which contribute to the peptide-binding groove. MHC Class II (I-Ap) is primarily restricted to antigen-presenting cells, including dendritic cells, macrophages, and B cells. These cells are responsible for capturing and processing antigens from the extracellular environment. Once the antigens are internalized, they are broken down into smaller peptides, which then bind to MHC Class II molecules within the endosomal compartments of these cells. MHC Class II (I-Ap) consists of an extracellular domain, a transmembrane domain, and a cytoplasmic tail. The extracellular domain is responsible for interacting with the antigenic peptides, while the transmembrane domain anchors the MHC Class II molecule to the cell membrane. The cytoplasmic tail plays a role in intracellular signaling events. HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.

Immunogen :

B10.p

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.5 µg/1x10^6 cells

Aliases :

cell surface glycoprotein; H-2 class II histocompatibility antigen, I-E beta chain; H2Eb; H-2Eb; H2-Eb1; histocompatibility 2, class II antigen E beta; Ia4; Ia-4; I-E beta MHC class II; major histocompatibility complex H-2E beta chain; MHC class II IE-b; MHC H2-IE-beta cell surface glycoprotein