CD35 Monoclonal Antibody (To5), Biotin | Invitrogen MA5-17713 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD35 Monoclonal Antibody (To5), Biotin

catalog :

MA5-17713

quantity :

100 ug

price :

US 414.00

clonality :

monoclonal

host :

mouse

conjugate :

biotin

clone name :

To5

The same clone is also sold as:

Santa Cruz Biotechnology: sc-20055 AC, sc-20055 HRP, sc-20055

reactivity :

human

application :

western blot, immunohistochemistry, flow cytometry, immunohistochemistry - frozen section

product information

Product Type :

Antibody

Product Name :

CD35 Monoclonal Antibody (To5), Biotin

Catalog # :

MA5-17713

Quantity :

100 ug

Price :

US 414.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 0.5 ug/1x10^6 cells, Immunohistochemistry (Frozen): Assay-dependent, Western Blot: Assay-dependent

Species :

Human

Clone :

To5

Isotype :

IgG1

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

CD35 (CR1, Complement Receptor 1) is a cell membrane-bound, monomeric glycoprotein and its primary function is to serve as the cellular receptor for C3b and C4b, the most important components of the complement system leading to clearance of foreign macromolecules. CD35 protein mediates cellular binding to particles and immune complexes that have activated complement. The CD35 complex is four different allotypes (C,A,B,D) C is 160 kDa; A is 190 kDa; B is 220 kDa and D is 250 kDa. CD35 is involved in the processing of immune complexes, promoting of binding and phagocytosis of C3b complexes and inhibition of complement activation. CD35 is on neutrophils, eosinophils, monocytes, B-cells, some NK-cells, erythrocytes, myeloid leukemias, follicular dendritic reticulum cells and is negative on basophils. Decreases in expression of CD35 protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in the CD35 gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants encoding different isoforms of CD35 have been characterized. An additional secreted form of CD35 have also been described but has not been fully characterized.

Immunogen :

Mouse monoclonal antibodies raised against human C3b receptor-enriched precipitates from tonsil cell membranes.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.5 ug/1x10^6 cells, Immunohistochemistry (Frozen): Assay-dependent, Western Blot: Assay-dependent

Aliases :

C3 binding protein; C3b/C4b receptor; C3-binding protein; C3BR; C4BR; CD35; CD35 antigen; complement component (3b/4b) receptor 1 (Knops blood group); Complement Component (3b/4b) receptor 1 including Knops blood group system; complement component 3b/4b receptor 1 (Knops blood group); complement receptor type 1; CR1; KN; Knops blood group antigen