CD3e Monoclonal Antibody (145-2C11), Biotin | Invitrogen MA5-17657 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD3e Monoclonal Antibody (145-2C11), Biotin

catalog :

MA5-17657

quantity :

300 ug

price :

US 329

clonality :

monoclonal

host :

hamsters

conjugate :

biotin

clone name :

145-2C11

reactivity :

mouse

application :

western blot, immunohistochemistry, flow cytometry, immunohistochemistry - frozen section, blocking or activating experiments

citations: 2

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; loading ...; fig s1e	Baumgartner C, Toifl S, Farlik M, Halbritter F, Scheicher R, Fischer I, et al. An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion. Cell Stem Cell. 2018;22:879-892.e6 pubmed publisher
blocking or activating experiments; mouse; 5 ug/ml	Gwack Y, Srikanth S, Oh Hora M, Hogan P, Lamperti E, Yamashita M, et al. Hair loss and defective T- and B-cell function in mice lacking ORAI1. Mol Cell Biol. 2008;28:5209-22 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD3e Monoclonal Antibody (145-2C11), Biotin

Catalog # :

MA5-17657

Quantity :

300 ug

Price :

US 329

Clonality :

Monoclonal

Purity :

Protein G

Host :

Armenian Hamster

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.2 µg/1x10^6 cells, Immunohistochemistry (Frozen): Assay Dependent, Western Blot: Assay Dependent

Species :

Mouse

Clone :

145-2C11

Isotype :

IgG

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Description :

The CD3 subunit complex which is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules and this association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. The genes encoding the CD3 epsilon, gamma and delta polypeptides are located on chromosome 11. Defects in the CD3 gene are associated with CD3 immunodeficiency.

Immunogen :

H-2Kb sp

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.2 µg/1x10^6 cells, Immunohistochemistry (Frozen): Assay Dependent, Western Blot: Assay Dependent

Aliases :

FLJ18683, T3E, TCRE, CD3-epsilon, CD3e antigen, epsilon polypeptide TiT3 complex, T-cell antigen receptor complex, epsilon subunit of T3, T-cell surface antigen T3/Leu-4 epsilon chain, T-cell surface glycoprotein CD3 epsilon chain