TCR beta Monoclonal Antibody (H57-597), Biotin | Invitrogen MA5-17649 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TCR beta Monoclonal Antibody (H57-597), Biotin

catalog :

MA5-17649

quantity :

100 ug

price :

US 181.00

clonality :

monoclonal

host :

hamsters

conjugate :

biotin

clone name :

H57-597

reactivity :

mouse

application :

immunohistochemistry, flow cytometry, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 2

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; loading ...; fig s2b	Zhou Y, Wang W, Zhao C, Wang Y, Wu H, Sun X, et al. Prostaglandin E2 Inhibits Group 2 Innate Lymphoid Cell Activation and Allergic Airway Inflammation Through E-Prostanoid 4-Cyclic Adenosine Monophosphate Signaling. Front Immunol. 2018;9:501 pubmed publisher
flow cytometry; mouse	Fucs R, Jesus J, Souza Junior P, Franco L, Verícimo M, Bellio M, et al. Frequency of natural regulatory CD4+CD25+ T lymphocytes determines the outcome of tolerance across fully mismatched MHC barrier through linked recognition of self and allogeneic stimuli. J Immunol. 2006;176:2324-9 pubmed

product information

Product Type :

Antibody

Product Name :

TCR beta Monoclonal Antibody (H57-597), Biotin

Catalog # :

MA5-17649

Quantity :

100 ug

Price :

US 181.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Armenian Hamster

Reactivity :

Mouse

Applications :

Flow Cytometry: 1.0 ug/1x10^6 cells, Immunohistochemistry (Frozen): Assay-dependent

Species :

Mouse

Clone :

H57-597

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease (ref5). T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.

Immunogen :

Affinity Purified D0-11.10 TCR

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1.0 ug/1x10^6 cells, Immunohistochemistry (Frozen): Assay-dependent

Aliases :

bTCR; FLJ22602; MGC117436; MGC22624; MGC23964; MGC71411; T cell receptor beta chain; t-cell antigen receptor; T-cell receptor; TCR beta; Tcra; Tcrb; TCRbeta; TCRD; Tib; TRA

more info or order :

Invitrogen product webpage