product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD8 alpha Monoclonal Antibody (CT-CD8a), PE
catalog :
MA5-17600
quantity :
300 ug
price :
US 782.00
clonality :
monoclonal
host :
rat
conjugate :
PE
clone name :
CT-CD8a
reactivity :
mouse, fruit fly
application :
immunocytochemistry, flow cytometry
more info or order :
Invitrogen product webpage
citations: 21
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse
Yassai M, Cooley B, Gorski J. Developmental dynamics of post-selection thymic DN iNKT. PLoS ONE. 2012;7:e43509 pubmed publisher
  • flow cytometry; mouse
Chen X, Vodanovic Jankovic S, Johnson B, Keller M, Komorowski R, Drobyski W. Absence of regulatory T-cell control of TH1 and TH17 cells is responsible for the autoimmune-mediated pathology in chronic graft-versus-host disease. Blood. 2007;110:3804-13 pubmed
  • immunocytochemistry; fruit fly ; 1:100
Wu J, Luo L. A protocol for mosaic analysis with a repressible cell marker (MARCM) in Drosophila. Nat Protoc. 2006;1:2583-9 pubmed
  • flow cytometry; mouse
Tivol E, Komorowski R, Drobyski W. Emergent autoimmunity in graft-versus-host disease. Blood. 2005;105:4885-91 pubmed
  • flow cytometry; mouse
Gray P, Arimilli S, Palmer E, Parks G, Alexander Miller M. Altered function in CD8+ T cells following paramyxovirus infection of the respiratory tract. J Virol. 2005;79:3339-49 pubmed
  • flow cytometry; mouse
Mischenko V, Kapina M, Eruslanov E, Kondratieva E, Lyadova I, Young D, et al. Mycobacterial dissemination and cellular responses after 1-lobe restricted tuberculosis infection of genetically susceptible and resistant mice. J Infect Dis. 2004;190:2137-45 pubmed
  • flow cytometry; mouse
Cabarrocas J, Piaggio E, Zappulla J, Desbois S, Mars L, Lassmann H, et al. A transgenic mouse model for T-cell ignorance of a glial autoantigen. J Autoimmun. 2004;22:179-89 pubmed
  • flow cytometry; mouse
Eruslanov E, Majorov K, Orlova M, Mischenko V, Kondratieva T, Apt A, et al. Lung cell responses to M. tuberculosis in genetically susceptible and resistant mice following intratracheal challenge. Clin Exp Immunol. 2004;135:19-28 pubmed
  • flow cytometry; mouse
Morin J, Faideau B, Gagnerault M, Lepault F, Boitard C, Boudaly S. Passive transfer of flt-3L-derived dendritic cells delays diabetes development in NOD mice and associates with early production of interleukin (IL)-4 and IL-10 in the spleen of recipient mice. Clin Exp Immunol. 2003;134:388-95 pubmed
  • flow cytometry; mouse
Egan P, Lawlor K, Alexander W, Wicks I. Suppressor of cytokine signaling-1 regulates acute inflammatory arthritis and T cell activation. J Clin Invest. 2003;111:915-24 pubmed
  • flow cytometry; mouse
Hsu S, Wu C, Han J, Lai M. Involvement of p38 mitogen-activated protein kinase in different stages of thymocyte development. Blood. 2003;101:970-6 pubmed
  • flow cytometry; mouse
Yu C, Feng M, Shih H, Lai M. Increased p300 expression inhibits glucocorticoid receptor-T-cell receptor antagonism but does not affect thymocyte positive selection. Mol Cell Biol. 2002;22:4556-66 pubmed
  • flow cytometry; mouse
Martin P, Ruiz S, Del Hoyo G, Anjuere F, Vargas H, López Bravo M, et al. Dramatic increase in lymph node dendritic cell number during infection by the mouse mammary tumor virus occurs by a CD62L-dependent blood-borne DC recruitment. Blood. 2002;99:1282-8 pubmed
  • flow cytometry; mouse; fig 3
Izeradjene K, Revillard J, Genestier L. Inhibition of thymidine synthesis by folate analogues induces a Fas-Fas ligand-independent deletion of superantigen-reactive peripheral T cells. Int Immunol. 2001;13:85-93 pubmed
  • flow cytometry; mouse
Martin P, del Hoyo G, Anjuere F, Ruiz S, Arias C, Marín A, et al. Concept of lymphoid versus myeloid dendritic cell lineages revisited: both CD8alpha(-) and CD8alpha(+) dendritic cells are generated from CD4(low) lymphoid-committed precursors. Blood. 2000;96:2511-9 pubmed
  • flow cytometry; mouse
de Oca R, Buendia A, Del Rio L, Sanchez J, Salinas J, Navarro J. Polymorphonuclear neutrophils are necessary for the recruitment of CD8(+) T cells in the liver in a pregnant mouse model of Chlamydophila abortus (Chlamydia psittaci serotype 1) infection. Infect Immun. 2000;68:1746-51 pubmed
  • flow cytometry; mouse; fig 1
Lepault F, Gagnerault M. Characterization of peripheral regulatory CD4+ T cells that prevent diabetes onset in nonobese diabetic mice. J Immunol. 2000;164:240-7 pubmed
  • flow cytometry; mouse
Dejbakhsh Jones S, Strober S. Identification of an early T cell progenitor for a pathway of T cell maturation in the bone marrow. Proc Natl Acad Sci U S A. 1999;96:14493-8 pubmed
  • flow cytometry; mouse; fig 4
Samoilova E, Horton J, Hilliard B, Liu T, Chen Y. IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: roles of IL-6 in the activation and differentiation of autoreactive T cells. J Immunol. 1998;161:6480-6 pubmed
Gilman K, Matiatos A, Cracchiolo M, Moon A, Davini D, Simpson R, et al. Multiagent Intratumoral Immunotherapy Can Be Effective in A20 Lymphoma Clearance and Generation of Systemic T Cell Immunity. Cancers (Basel). 2023;15: pubmed publisher
Newrzela S, Cornils K, Heinrich T, Schläger J, Yi J, Lysenko O, et al. Retroviral insertional mutagenesis can contribute to immortalization of mature T lymphocytes. Mol Med. 2011;17:1223-32 pubmed publisher
product information
Product Type :
Antibody
Product Name :
CD8 alpha Monoclonal Antibody (CT-CD8a), PE
Catalog # :
MA5-17600
Quantity :
300 ug
Price :
US 782.00
Clonality :
Monoclonal
Purity :
Protein G
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 1.0 ug/1x10^6 cells
Species :
Mouse
Clone :
CT-CD8a
Isotype :
IgG2a
Storage :
4 C, do not freeze
Description :
Cluster of differentiation 8 (CD8), a type I transmembrane glycoprotein of the immunoglobulin family of receptors, plays an integral role in signal transduction, and T cell differentiation and activation. CD8 is predominantly expressed on T cells as a disulfide-linked heterodimer of CD8alpha and CD8beta, where it functions as a co-receptor, along with T cell receptor (TCR), for major histocompatibilty complex class I (MHC-I) molecules; whereas its counterpart, CD4, acts as a co-receptor for MHC-II molecules. CD8 exists on the cell surface, where the CD8alpha chain is essential for binding to MHC-I. CD8 is also expressed on a subset of T cells, NK cells, monocytes and dendritic cells as disulfide-linked homodimers of CD8alpha. Ligation of MHC-I/peptide complexes presented by antigen-presenting cells (APCs), triggers the recruitment of lymphocyte-specific protein tyrosine kinase (Lck), which leads to lymphokine production, motility and cytotoxic T lymphocyte (CTL) activation. Once activated, CTLs play a crucial role in the clearance of pathogens and tumor cells. Differentiation of naive CD8+ T cells into CTLs is strongly enhanced by IL-2, IL-12 and TGF-beta1.
Immunogen :
Mouse CD8a
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1.0 ug/1x10^6 cells
Aliases :
BB154331; CD8; CD8 alpha; CD8 alpha chain; CD8 alpha chain precursor; CD8 antigen; CD8 antigen 32 kDa chain; CD8 antigen 37 kDa chain; CD8 antigen alpha polypeptide; CD8 antigen alpha protein; CD8 antigen alpha protein precursor; CD8 antigen alpha-chain; CD8 antigen beta polypeptide; CD8 antigen beta polypeptide precursor; CD8 antigen beta-chain; CD8 antigen, alpha chain; CD8 antigen, alpha polypeptide; CD8 antigen, alpha polypeptide (p32); CD8 antigen, alpha-chain; CD8 antigen, beta chain; CD8 antigen, beta chain 1; CD8 antigen, beta polypeptide; CD8 antigen, beta polypeptide 1 (p37); CD8 antigen, beta-chain; CD8 beta; CD8 beta chain; CD8 beta-2; CD8a; CD8A antigen alpha; CD8a molecule; CD8A; T-cell surface glycoprotein; CD8alpha; CD8B; CD8b antigen; CD8b molecule; CD8b molecule pseudogene; Cd8b1; CD8beta; CD8BP; fCD8; LEU2; Leu-2; Leu2 T-lymphocyte antigen; leu-2a; Ly-2; LY3; Ly-3; Ly-35; Ly-B; Ly-C; Lymphocyte antigen 3; Lyt2; Lyt-2; Lyt-2.1 lymphocyte differentiation antigen (AA at 100); Lyt3; Lyt-3; MAL; membrane glycoprotein; membrane protein; OKT8 T-cell antigen; OX-8 membrane antigen; p32; P37; RHACD8-4; T cell co-receptor; T lymphocyte surface glycoprotein beta chain; T8 T-cell antigen; T-cell antigen Leu2; T-cell membrane glycoprotein Ly-3; T-cell surface glycoprotein; T-cell surface glycoprotein CD8 alpha chain; T-cell surface glycoprotein CD8 beta chain; T-cell surface glycoprotein Lyt-2; T-cell surface glycoprotein Lyt-3; T-cell surface molecule; T-lymphocyte differentiation antigen T8/Leu-2; type I transmembrane glycoprotein
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA