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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD8 alpha Monoclonal Antibody (CT-CD8a)
catalog :
MA5-17594
quantity :
200 ug
price :
US 471.00
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
CT-CD8a
reactivity :
mouse, fruit fly
application :
immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 72
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| Wells J, Cowled C, Farzaneh F, Noble A. Combined triggering of dendritic cell receptors results in synergistic activation and potent cytotoxic immunity. J Immunol. 2008;181:3422-31 pubmed
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| Chen X, Vodanovic Jankovic S, Johnson B, Keller M, Komorowski R, Drobyski W. Absence of regulatory T-cell control of TH1 and TH17 cells is responsible for the autoimmune-mediated pathology in chronic graft-versus-host disease. Blood. 2007;110:3804-13 pubmed
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| Moulton R, Mashruwala M, Smith A, Lindsey D, Wetsel R, Haviland D, et al. Complement C5a anaphylatoxin is an innate determinant of dendritic cell-induced Th1 immunity to Mycobacterium bovis BCG infection in mice. J Leukoc Biol. 2007;82:956-67 pubmed
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| Lepenies B, Cramer J, Burchard G, Wagner H, Kirschning C, Jacobs T. Induction of experimental cerebral malaria is independent of TLR2/4/9. Med Microbiol Immunol. 2008;197:39-44 pubmed
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| Wu J, Luo L. A protocol for dissecting Drosophila melanogaster brains for live imaging or immunostaining. Nat Protoc. 2006;1:2110-5 pubmed
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| Wu J, Luo L. A protocol for mosaic analysis with a repressible cell marker (MARCM) in Drosophila. Nat Protoc. 2006;1:2583-9 pubmed
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| Hamm S, Heit A, Koffler M, Huster K, Akira S, Busch D, et al. Immunostimulatory RNA is a potent inducer of antigen-specific cytotoxic and humoral immune response in vivo. Int Immunol. 2007;19:297-304 pubmed
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| de Jersey J, Snelgrove S, Palmer S, Teteris S, Mullbacher A, Miller J, et al. Beta cells cannot directly prime diabetogenic CD8 T cells in nonobese diabetic mice. Proc Natl Acad Sci U S A. 2007;104:1295-300 pubmed
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| Fukatsu K, Sakamoto S, Hara E, Ueno C, Maeshima Y, Matsumoto I, et al. Gut ischemia-reperfusion affects gut mucosal immunity: a possible mechanism for infectious complications after severe surgical insults. Crit Care Med. 2006;34:182-7 pubmed
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| Tsunoda I, Kuang L, Kobayashi Warren M, Fujinami R. Central nervous system pathology caused by autoreactive CD8+ T-cell clones following virus infection. J Virol. 2005;79:14640-6 pubmed
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| Garcia Ojeda M, Dejbakhsh Jones S, Chatterjea Matthes D, Mukhopadhyay A, BitMansour A, Weissman I, et al. Stepwise development of committed progenitors in the bone marrow that generate functional T cells in the absence of the thymus. J Immunol. 2005;175:4363-73 pubmed
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| Koyama K. Dendritic cell expansion occurs in mesenteric lymph nodes of B10.BR mice infected with the murine nematode parasite Trichuris muris. Parasitol Res. 2005;97:186-90 pubmed
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| Tivol E, Komorowski R, Drobyski W. Emergent autoimmunity in graft-versus-host disease. Blood. 2005;105:4885-91 pubmed
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| Gray P, Arimilli S, Palmer E, Parks G, Alexander Miller M. Altered function in CD8+ T cells following paramyxovirus infection of the respiratory tract. J Virol. 2005;79:3339-49 pubmed
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| Mischenko V, Kapina M, Eruslanov E, Kondratieva E, Lyadova I, Young D, et al. Mycobacterial dissemination and cellular responses after 1-lobe restricted tuberculosis infection of genetically susceptible and resistant mice. J Infect Dis. 2004;190:2137-45 pubmed
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| van Santen H, Benoist C, Mathis D. Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells. J Exp Med. 2004;200:1221-30 pubmed
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| Zheng S, Jiang J, Shen H, Chen Y. Reduced apoptosis and ameliorated listeriosis in TRAIL-null mice. J Immunol. 2004;173:5652-8 pubmed
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| Dalton J, Howell G, Pearson J, Scott P, Carding S. Fas-Fas ligand interactions are essential for the binding to and killing of activated macrophages by gamma delta T cells. J Immunol. 2004;173:3660-7 pubmed
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| Mattner J, Wandersee Steinhäuser A, Pahl A, Rollinghoff M, Majeau G, Hochman P, et al. Protection against progressive leishmaniasis by IFN-beta. J Immunol. 2004;172:7574-82 pubmed
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| Hequet O, Vocanson M, Saint Mezard P, Kaiserlian D, Nicolas J, Berard F. CD4+ T cells prevent skin autoimmunity during chronic autologous graft-versus-host-disease. Am J Transplant. 2004;4:872-8 pubmed
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| Yuan Y, Shen H, Franklin D, Scadden D, Cheng T. In vivo self-renewing divisions of haematopoietic stem cells are increased in the absence of the early G1-phase inhibitor, p18INK4C. Nat Cell Biol. 2004;6:436-42 pubmed
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| Cabarrocas J, Piaggio E, Zappulla J, Desbois S, Mars L, Lassmann H, et al. A transgenic mouse model for T-cell ignorance of a glial autoantigen. J Autoimmun. 2004;22:179-89 pubmed
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| Steptoe R, Stankovic S, Lopaticki S, Jones L, Harrison L, Morahan G. Persistence of recipient lymphocytes in NOD mice after irradiation and bone marrow transplantation. J Autoimmun. 2004;22:131-8 pubmed
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| Ishihara K, Sawa S, Ikushima H, Hirota S, Atsumi T, Kamimura D, et al. The point mutation of tyrosine 759 of the IL-6 family cytokine receptor gp130 synergizes with HTLV-1 pX in promoting rheumatoid arthritis-like arthritis. Int Immunol. 2004;16:455-65 pubmed
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| Chen B, Cui X, Sempowski G, Domen J, Chao N. Hematopoietic stem cell dose correlates with the speed of immune reconstitution after stem cell transplantation. Blood. 2004;103:4344-52 pubmed
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| Schleicher U, Mattner J, Blos M, Schindler H, Rollinghoff M, Karaghiosoff M, et al. Control of Leishmania major in the absence of Tyk2 kinase. Eur J Immunol. 2004;34:519-29 pubmed
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| Turley S, Poirot L, Hattori M, Benoist C, Mathis D. Physiological beta cell death triggers priming of self-reactive T cells by dendritic cells in a type-1 diabetes model. J Exp Med. 2003;198:1527-37 pubmed
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| Choi E, Chen J, Wooldridge L, Salio M, Lissina A, Lissin N, et al. High avidity antigen-specific CTL identified by CD8-independent tetramer staining. J Immunol. 2003;171:5116-23 pubmed
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| Chen B, Cui X, Sempowski G, Chao N. Growth hormone accelerates immune recovery following allogeneic T-cell-depleted bone marrow transplantation in mice. Exp Hematol. 2003;31:953-8 pubmed
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| Richards M, Liu F, Iwasaki H, Akashi K, Link D. Pivotal role of granulocyte colony-stimulating factor in the development of progenitors in the common myeloid pathway. Blood. 2003;102:3562-8 pubmed
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| Chatterjea Matthes D, Garcia Ojeda M, Dejbakhsh Jones S, Jerabek L, Manz M, Weissman I, et al. Early defect prethymic in bone marrow T cell progenitors in athymic nu/nu mice. J Immunol. 2003;171:1207-15 pubmed
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| Norris H, Lybarger L, Martin A, Andersen H, Chervenak D, Chervenak R. TCRbeta enhancer activation occurs in some but not all cells with T cell lineage developmental potential. Cell Immunol. 2003;222:164-74 pubmed
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| Blos M, Schleicher U, Soares Rocha F, Meissner U, Rollinghoff M, Bogdan C. Organ-specific and stage-dependent control of Leishmania major infection by inducible nitric oxide synthase and phagocyte NADPH oxidase. Eur J Immunol. 2003;33:1224-34 pubmed
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| Hsu S, Wu C, Han J, Lai M. Involvement of p38 mitogen-activated protein kinase in different stages of thymocyte development. Blood. 2003;101:970-6 pubmed
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| Litvinova E, Maury S, Boyer O, Bruel S, Benard L, Boisserie G, et al. Graft-versus-leukemia effect after suicide-gene-mediated control of graft-versus-host disease. Blood. 2002;100:2020-5 pubmed
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| Carrithers M, Visintin I, Viret C, Janeway C. Role of genetic background in P selectin-dependent immune surveillance of the central nervous system. J Neuroimmunol. 2002;129:51-7 pubmed
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| Yu C, Feng M, Shih H, Lai M. Increased p300 expression inhibits glucocorticoid receptor-T-cell receptor antagonism but does not affect thymocyte positive selection. Mol Cell Biol. 2002;22:4556-66 pubmed
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| Martin P, Ruiz S, Del Hoyo G, Anjuere F, Vargas H, López Bravo M, et al. Dramatic increase in lymph node dendritic cell number during infection by the mouse mammary tumor virus occurs by a CD62L-dependent blood-borne DC recruitment. Blood. 2002;99:1282-8 pubmed
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| Martinez del Hoyo G, Martin P, Arias C, Marín A, Ardavin C. CD8alpha+ dendritic cells originate from the CD8alpha- dendritic cell subset by a maturation process involving CD8alpha, DEC-205, and CD24 up-regulation. Blood. 2002;99:999-1004 pubmed
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| Wu T, Lee J, Lai Y, Hsu J, Tsai C, Lee Y, et al. Reduced expression of Bcl-2 in CD8+ T cells deficient in the IL-15 receptor alpha-chain. J Immunol. 2002;168:705-12 pubmed
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| Chen B, Cui X, Sempowski G, Gooding M, Liu C, Haynes B, et al. A comparison of murine T-cell-depleted adult bone marrow and full-term fetal blood cells in hematopoietic engraftment and immune reconstitution. Blood. 2002;99:364-71 pubmed
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| Roach D, Martin E, Bean A, Rennick D, Briscoe H, Britton W. Endogenous inhibition of antimycobacterial immunity by IL-10 varies between mycobacterial species. Scand J Immunol. 2001;54:163-70 pubmed
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| Zhang J, Kabra N, Cado D, Kang C, Winoto A. FADD-deficient T cells exhibit a disaccord in regulation of the cell cycle machinery. J Biol Chem. 2001;276:29815-8 pubmed
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| Shimizu C, Kawamoto H, Yamashita M, Kimura M, Kondou E, Kaneko Y, et al. Progression of T cell lineage restriction in the earliest subpopulation of murine adult thymus visualized by the expression of lck proximal promoter activity. Int Immunol. 2001;13:105-17 pubmed
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| Martin P, del Hoyo G, Anjuere F, Ruiz S, Arias C, Marín A, et al. Concept of lymphoid versus myeloid dendritic cell lineages revisited: both CD8alpha(-) and CD8alpha(+) dendritic cells are generated from CD4(low) lymphoid-committed precursors. Blood. 2000;96:2511-9 pubmed
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| Feng C, Britton W, Palendira U, Groat N, Briscoe H, Bean A. Up-regulation of VCAM-1 and differential expansion of beta integrin-expressing T lymphocytes are associated with immunity to pulmonary Mycobacterium tuberculosis infection. J Immunol. 2000;164:4853-60 pubmed
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| de Oca R, Buendia A, Del Rio L, Sanchez J, Salinas J, Navarro J. Polymorphonuclear neutrophils are necessary for the recruitment of CD8(+) T cells in the liver in a pregnant mouse model of Chlamydophila abortus (Chlamydia psittaci serotype 1) infection. Infect Immun. 2000;68:1746-51 pubmed
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| Lepault F, Gagnerault M. Characterization of peripheral regulatory CD4+ T cells that prevent diabetes onset in nonobese diabetic mice. J Immunol. 2000;164:240-7 pubmed
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| Zeng D, Lewis D, Dejbakhsh Jones S, Lan F, Garcia Ojeda M, Sibley R, et al. Bone marrow NK1.1(-) and NK1.1(+) T cells reciprocally regulate acute graft versus host disease. J Exp Med. 1999;189:1073-81 pubmed
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| Bix M, Wang Z, Thiel B, Schork N, Locksley R. Genetic regulation of commitment to interleukin 4 production by a CD4(+) T cell-intrinsic mechanism. J Exp Med. 1998;188:2289-99 pubmed
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| Salomon B, Cohen J, Masurier C, Klatzmann D. Three populations of mouse lymph node dendritic cells with different origins and dynamics. J Immunol. 1998;160:708-17 pubmed
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Kocks J, Davalos Misslitz A, Hintzen G, Ohl L, Forster R. Regulatory T cells interfere with the development of bronchus-associated lymphoid tissue. J Exp Med. 2007;204:723-34 pubmed
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Galkina E, Tanousis K, Preece G, Tolaini M, Kioussis D, Florey O, et al. L-selectin shedding does not regulate constitutive T cell trafficking but controls the migration pathways of antigen-activated T lymphocytes. J Exp Med. 2003;198:1323-35 pubmed
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Moron G, Rueda P, Casal I, Leclerc C. CD8alpha- CD11b+ dendritic cells present exogenous virus-like particles to CD8+ T cells and subsequently express CD8alpha and CD205 molecules. J Exp Med. 2002;195:1233-45 pubmed
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Moser J, Altman J, Lukacher A. Antiviral CD8+ T cell responses in neonatal mice: susceptibility to polyoma virus-induced tumors is associated with lack of cytotoxic function by viral antigen-specific T cells. J Exp Med. 2001;193:595-606 pubmed
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Bhandoola A, Dolnick B, Fayad N, Nussenzweig A, Singer A. Immature thymocytes undergoing receptor rearrangements are resistant to an Atm-dependent death pathway activated in mature T cells by double-stranded DNA breaks. J Exp Med. 2000;192:891-7 pubmed
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product information
Product Type :
Antibody
Product Name :
CD8 alpha Monoclonal Antibody (CT-CD8a)
Catalog # :
MA5-17594
Quantity :
200 ug
Price :
US 471.00
Clonality :
Monoclonal
Purity :
Protein G
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 1.0 ug/1x10^6 cells, Immunohistochemistry (Frozen): Assay-dependent, Immunohistochemistry (Paraffin): Assay-dependent, T-Cell Activation: Assay-dependent
Species :
Mouse
Clone :
CT-CD8a
Isotype :
IgG2a
Storage :
Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.
Description :
Cluster of differentiation 8 (CD8), a type I transmembrane glycoprotein of the immunoglobulin family of receptors, plays an integral role in signal transduction, and T cell differentiation and activation. CD8 is predominantly expressed on T cells as a disulfide-linked heterodimer of CD8alpha and CD8beta, where it functions as a co-receptor, along with T cell receptor (TCR), for major histocompatibilty complex class I (MHC-I) molecules; whereas its counterpart, CD4, acts as a co-receptor for MHC-II molecules. CD8 exists on the cell surface, where the CD8alpha chain is essential for binding to MHC-I. CD8 is also expressed on a subset of T cells, NK cells, monocytes and dendritic cells as disulfide-linked homodimers of CD8alpha. Ligation of MHC-I/peptide complexes presented by antigen-presenting cells (APCs), triggers the recruitment of lymphocyte-specific protein tyrosine kinase (Lck), which leads to lymphokine production, motility and cytotoxic T lymphocyte (CTL) activation. Once activated, CTLs play a crucial role in the clearance of pathogens and tumor cells. Differentiation of naive CD8+ T cells into CTLs is strongly enhanced by IL-2, IL-12 and TGF-beta1.
Immunogen :
Mouse CD8a
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1.0 ug/1x10^6 cells, Immunohistochemistry (Frozen): Assay-dependent, Immunohistochemistry (Paraffin): Assay-dependent, T-Cell Activation: Assay-dependent
Aliases :
BB154331; CD8; CD8 alpha; CD8 alpha chain; CD8 alpha chain precursor; CD8 antigen; CD8 antigen 32 kDa chain; CD8 antigen 37 kDa chain; CD8 antigen alpha polypeptide; CD8 antigen alpha protein; CD8 antigen alpha protein precursor; CD8 antigen alpha-chain; CD8 antigen beta polypeptide; CD8 antigen beta polypeptide precursor; CD8 antigen beta-chain; CD8 antigen, alpha chain; CD8 antigen, alpha polypeptide; CD8 antigen, alpha polypeptide (p32); CD8 antigen, alpha-chain; CD8 antigen, beta chain; CD8 antigen, beta chain 1; CD8 antigen, beta polypeptide; CD8 antigen, beta polypeptide 1 (p37); CD8 antigen, beta-chain; CD8 beta; CD8 beta chain; CD8 beta-2; CD8a; CD8A antigen alpha; CD8a molecule; CD8A; T-cell surface glycoprotein; CD8alpha; CD8B; CD8b antigen; CD8b molecule; CD8b molecule pseudogene; Cd8b1; CD8beta; CD8BP; fCD8; LEU2; Leu-2; Leu2 T-lymphocyte antigen; leu-2a; Ly-2; LY3; Ly-3; Ly-35; Ly-B; Ly-C; Lymphocyte antigen 3; Lyt2; Lyt-2; Lyt-2.1 lymphocyte differentiation antigen (AA at 100); Lyt3; Lyt-3; MAL; membrane glycoprotein; membrane protein; OKT8 T-cell antigen; OX-8 membrane antigen; p32; P37; RHACD8-4; T cell co-receptor; T lymphocyte surface glycoprotein beta chain; T8 T-cell antigen; T-cell antigen Leu2; T-cell membrane glycoprotein Ly-3; T-cell surface glycoprotein; T-cell surface glycoprotein CD8 alpha chain; T-cell surface glycoprotein CD8 beta chain; T-cell surface glycoprotein Lyt-2; T-cell surface glycoprotein Lyt-3; T-cell surface molecule; T-lymphocyte differentiation antigen T8/Leu-2; type I transmembrane glycoprotein
more info or order :
company information

Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com81 Wyman Street
Waltham, MA USA 02451
800-678-5599
headquarters: USA
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