LDHA Monoclonal Antibody (AF14A11) | Invitrogen MA5-17247 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

LDHA Monoclonal Antibody (AF14A11)

catalog :

MA5-17247

quantity :

100 µL

price :

US 456

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

AF14A11

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunoprecipitation

citations: 1

Reference
Kaushik D, Bhattacharya A, Mirzaei R, Rawji K, Ahn Y, Rho J, et al. Enhanced glycolytic metabolism supports transmigration of brain-infiltrating macrophages in multiple sclerosis. J Clin Invest. 2019;129:3277-3292 pubmed publisher

product information

Product Type :

Antibody

Product Name :

LDHA Monoclonal Antibody (AF14A11)

Catalog # :

MA5-17247

Quantity :

100 µL

Price :

US 456

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Applications :

ELISA: Assay Dependent, Immunoprecipitation: 2 µg, Western Blot: 0.1 µg/mL

Species :

Human, Mouse, Rat

Clone :

AF14A11

Isotype :

IgG2b

Storage :

-20°C

Description :

Lactate dehydrogenase (LDH) is the enzyme in the glycolytic pathway that converts pyruvate to lactate with concomitant interconversion of NADH and NAD+. In mammals, the enzyme is encoded by three genes: LDHA (M or muscle form), LDHB (H or heart form), and LDHC (X or testis form). The three human LDHs have 84-89% sequence similarities and 69-75% amino acid identities. There are five different LDH isoenzymes based on the proportion of M and H chains existing in the LDH tetrameric structure. The LDHA is hypoxia inducible and its expression is directly controlled by the transcriptional activity of the hypoxia inducible factor 1a (HIF1a). LDHB is also known to be upregulated in many cancers. Mutations in the LDHA gene can lead to Glycogen storage disease 11 (GSD11).

Immunogen :

Recombinant human protein purified from E.coli (His-LDHA)

Format :

liquid

Applications w/Dilutions :

ELISA: Assay Dependent, Immunoprecipitation: 2 µg, Western Blot: 0.1 µg/mL

Aliases :

cell proliferation-inducing gene 19 protein; epididymis secretory sperm binding protein Li 133P; GSD11; HEL-S-133P; l7R2; Lactate Dehydrogenase; lactate dehydrogenase 1, A chain; lactate dehydrogenase A; lactate dehydrogenase A4; lactate dehydrogenase A-like; lactate dehydrogenase M; lactate dehydrogenase-A; lactate dehydrogenase-M; Lactic Dehydrogenase; LDH; LDH muscle subunit; Ldh1; Ldh-1; Ldha; LDH-A; ldha protein; ldha1; LDH-A4 muscle-specific isozyme; glycolytic enzyme; LDHM; LDH-M; L-lactate dehydrogenase; L-lactate dehydrogenase A chain; M-LDH; OTTHUMP00000165206; PIG19; proliferation-inducing gene 19; renal carcinoma antigen NY-REN-59