MCP-1 Monoclonal Antibody (2D8) | Invitrogen MA5-17040 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

MCP-1 Monoclonal Antibody (2D8)

catalog :

MA5-17040

quantity :

100 ug

price :

US 480.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2D8

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 24

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; 1:400; loading ...; fig 6c	Song M, YEKU O, Rafiq S, Purdon T, Dong X, Zhu L, et al. Tumor derived UBR5 promotes ovarian cancer growth and metastasis through inducing immunosuppressive macrophages. Nat Commun. 2020;11:6298 pubmed publisher
western blot; mouse; fig 3	Wagner J, Jaurich H, Wallner C, Abraham S, Becerikli M, Dadras M, et al. Diminished bone regeneration after debridement of posttraumatic osteomyelitis is accompanied by altered cytokine levels, elevated B cell activity, and increased osteoclast activity. J Orthop Res. 2017;35:2425-2434 pubmed publisher
	Tang H, Wang J, Fang Y, Yin Y, Liu W, Hu Y, et al. Hepatic transcriptome discloses the potential targets of Xuefu Zhuyu Decoction ameliorating non-alcoholic fatty liver disease induced by high-fat diet. J Tradit Complement Med. 2024;14:135-147 pubmed publisher
	Sommer J, Ehnis H, Seitz T, Schneider J, Wild A, Moceri S, et al. Four-and-a-Half LIM-Domain Protein 2 (FHL2) Induces Neuropeptide Y (NPY) in Macrophages in Visceral Adipose Tissue and Promotes Diet-Induced Obesity. Int J Mol Sci. 2023;24: pubmed publisher
	Wen D, Hu L, Shan J, Zhang H, Hu L, Yuan A, et al. Mechanical injury accentuates lipid deposition in ApoE-/- mice and advance aortic valve stenosis: A novel modified aortic valve stenosis model. Front Cardiovasc Med. 2023;10:1119746 pubmed publisher
	Doppler C, Messner B, Mimler T, Schachner B, Rezk M, Ganh xf6 r C, et al. Noncanonical atherosclerosis as the driving force in tricuspid aortic valve associated aneurysms - A trace collection. J Lipid Res. 2023;64:100338 pubmed publisher
	Juin S, Pushpakumar S, Tyagi S, Sen U. Glucosidase inhibitor, Nimbidiol ameliorates renal fibrosis and dysfunction in type-1 diabetes. Sci Rep. 2022;12:21707 pubmed publisher
	Gong P, Ding Y, Sun R, Jiang Z, Li W, Su X, et al. Mesenchymal stem cells alleviate systemic sclerosis by inhibiting the recruitment of pathogenic macrophages. Cell Death Discov. 2022;8:466 pubmed publisher
	Lee P, Sui Y, Liu T, Tsang N, Huang C, Lin T, et al. Epstein-Barr viral product-containing exosomes promote fibrosis and nasopharyngeal carcinoma progression through activation of YAP1/FAPα signaling in fibroblasts. J Exp Clin Cancer Res. 2022;41:254 pubmed publisher
	Jang J, Cho E, Cho Y, Ganzorig B, Kim K, Kim M, et al. Environment-Sensitive Ectodomain Shedding of Epithin/PRSS14 Increases Metastatic Potential of Breast Cancer Cells by Producing CCL2. Mol Cells. 2022;45:564-574 pubmed publisher
	Ammer Herrmenau C, Wolf L, Nasrin S, Ramu I, Roggiolani R, Goetze R, et al. Activity of acute pancreatitis is modified by secreted protein acidic and rich in cysteine ablation. United European Gastroenterol J. 2022;10:544-555 pubmed publisher
	Vallecillo Z xfa niga M, Poulson P, Luddington J, Arnold C, Rathgeber M, Kartchner B, et al. Therapeutic Benefit of Galectin-1: Beyond Membrane Repair, a Multifaceted Approach to LGMD2B. Cells. 2021;10: pubmed publisher
	Devocelle A, Lecru L, Ferlicot S, Bessede T, Candelier J, Giron Michel J, et al. IL-15 Prevents Renal Fibrosis by Inhibiting Collagen Synthesis: A New Pathway in Chronic Kidney Disease?. Int J Mol Sci. 2021;22: pubmed publisher
	Kozlowska U, Klimczak A, Bednarowicz K, Zalewski T, Rozwadowska N, Chojnacka K, et al. Assessment of Immunological Potential of Glial Restricted Progenitor Graft In Vivo-Is Immunosuppression Mandatory?. Cells. 2021;10: pubmed publisher
	Masselli E, Carubbi C, Pozzi G, Percesepe A, Campanelli R, Villani L, et al. Impact of the rs1024611 Polymorphism of CCL2 on the Pathophysiology and Outcome of Primary Myelofibrosis. Cancers (Basel). 2021;13: pubmed publisher
	Fields L, Ito T, Kobayashi K, Ichihara Y, Podaru M, Hussain M, et al. Epicardial placement of human MSC-loaded fibrin sealant films for heart failure: Preclinical efficacy and mechanistic data. Mol Ther. 2021;29:2554-2570 pubmed publisher
	Moruzzi M, Kl xf6 ting N, Bl xfc her M, Martinelli I, Tayebati S, Gabrielli M, et al. Tart Cherry Juice and Seeds Affect Pro-Inflammatory Markers in Visceral Adipose Tissue of High-Fat Diet Obese Rats. Molecules. 2021;26: pubmed publisher
	Li X, Wen J, Dong Y, Zhang Q, Guan J, Liu F, et al. Wnt5a promotes renal tubular inflammation in diabetic nephropathy by binding to CD146 through noncanonical Wnt signaling. Cell Death Dis. 2021;12:92 pubmed publisher
	Tavora B, Mederer T, Wessel K, Ruffing S, Sadjadi M, Missmahl M, et al. Tumoural activation of TLR3-SLIT2 axis in endothelium drives metastasis. Nature. 2020;586:299-304 pubmed publisher
	Gelsomino L, Naimo G, Malivindi R, Augimeri G, Panza S, Giordano C, et al. Knockdown of Leptin Receptor Affects Macrophage Phenotype in the Tumor Microenvironment Inhibiting Breast Cancer Growth and Progression. Cancers (Basel). 2020;12: pubmed publisher
	Su W, Han H, Wang Y, Zhang B, Zhou B, Cheng Y, et al. The Polycomb Repressor Complex 1 Drives Double-Negative Prostate Cancer Metastasis by Coordinating Stemness and Immune Suppression. Cancer Cell. 2019;36:139-155.e10 pubmed publisher
	Fisher B, Green R, Brown R, Wood M, Hensley McBain T, Fisher C, et al. Liver macrophage-associated inflammation correlates with SIV burden and is substantially reduced following cART. PLoS Pathog. 2018;14:e1006871 pubmed publisher
	Rhys H, Dell accio F, Pitzalis C, Moore A, Norling L, Perretti M. Neutrophil Microvesicles from Healthy Control and Rheumatoid Arthritis Patients Prevent the Inflammatory Activation of Macrophages. EBioMedicine. 2018;29:60-69 pubmed publisher
	Li D, Fu H, Tong J, Li Y, Qu L, Wang P, et al. Cholinergic anti-inflammatory pathway inhibits neointimal hyperplasia by suppressing inflammation and oxidative stress. Redox Biol. 2018;15:22-33 pubmed publisher

product information

Product Type :

Antibody

Product Name :

MCP-1 Monoclonal Antibody (2D8)

Catalog # :

MA5-17040

Quantity :

100 ug

Price :

US 480.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human, Mouse, Non-human primate

Applications :

ELISA: 1:10,000, Flow Cytometry: 1:200-1:400, Immunocytochemistry: 1:200-1:1,000, Immunohistochemistry (Paraffin): 1:200-1:1,000, Western Blot: 1:500-1:2,000

Species :

Human, Mouse, Non-human primate

Clone :

2D8

Isotype :

IgG1

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4.

Immunogen :

Purified recombinant fragment of human CCL2 expressed in E. Coli.

Format :

Liquid

Applications w/Dilutions :

ELISA: 1:10,000, Flow Cytometry: 1:200-1:400, Immunocytochemistry: 1:200-1:1,000, Immunohistochemistry (Paraffin): 1:200-1:1,000, Western Blot: 1:500-1:2,000

Aliases :

Acidic seminal fluid protein; AI323594; C-C motif chemokine 2; C-C motif chemokine ligand 2; Ccl2; chemokine (C-C motif) ligand 2; GDCF-2; HC11; H-MCP-1; HSMCR30; immediate-early serum-responsive JE protein; immediate-early serum-responsive protein JE; Je; MCAF; Mcp1; MCP-1; MCP1A; MCP-1A; MGC9434; Monocyte chemoattractant protein 1; monocyte chemoattractant protein-1; monocyte chemotactic and activating factor; Monocyte chemotactic protein 1; monocyte chemotactic protein 1A; Monocyte secretory protein JE; monocyte-chemoattractant protein-1 precursor; platelet-derived growth factor-inducible protein JE; RP23-350G1.3; SCYA2; Sigje; small inducible cytokine A2; small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je); small inducible cytokine subfamily A (Cys-Cys), member 2; small inducible gene JE; small-inducible cytokine A2; SMC-CF

more info or order :

Invitrogen product webpage