ALDH2 Monoclonal Antibody (4G6A3) | Invitrogen MA5-17029 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

ALDH2 Monoclonal Antibody (4G6A3)

catalog :

MA5-17029

quantity :

100 ug

price :

US 520.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4G6A3

The same clone is also sold as:

Novus Biologicals: NBP2-37397

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

citations: 5

Reference
Yao P, Zhang Z, Liu H, Jiang P, Li W, Du W. p53 protects against alcoholic fatty liver disease via ALDH2 inhibition. EMBO J. 2023;42:e112304 pubmed publisher
Pan G, Roy B, Harding P, Lanigan T, Hilgarth R, Thandavarayan R, et al. Effects of intracardiac delivery of aldehyde dehydrogenase 2 gene in myocardial salvage. Gene Ther. 2023;30:115-121 pubmed publisher
Roy B, Palaniyandi S. A role for aldehyde dehydrogenase (ALDH) 2 in angiotensin II-mediated decrease in angiogenesis of coronary endothelial cells. Microvasc Res. 2021;135:104133 pubmed publisher
Ruan L, McNamara J, Zhang X, Chang A, Zhu J, Dong Y, et al. Solid-phase inclusion as a mechanism for regulating unfolded proteins in the mitochondrial matrix. Sci Adv. 2020;6:eabc7288 pubmed publisher
Sanchez A, Li C, Andrews B, Asenjo J, Samulski R. AAV Gene Therapy for Alcoholism: Inhibition of Mitochondrial Aldehyde Dehydrogenase Enzyme Expression in Hepatoma Cells. Hum Gene Ther. 2017;28:717-725 pubmed publisher

product information

Product Type :

Antibody

Product Name :

ALDH2 Monoclonal Antibody (4G6A3)

Catalog # :

MA5-17029

Quantity :

100 ug

Price :

US 520.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human, Mouse, Non-human primate, Rat

Applications :

Flow Cytometry: 1:200 - 1:400, Immunocytochemistry: 1:75, Immunohistochemistry (Paraffin): Assay-dependent, Western Blot: 1 ug/mL

Species :

Human, Mouse, Non-human primate, Rat

Clone :

4G6A3

Isotype :

IgG1

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

ALDH2 belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Asians have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Asians than among Caucasians could be related to the absence of the mitochondrial isozyme.

Immunogen :

Purified recombinant fragment of human ALDH2 (amino acids: 317-517) expressed in E. Coli.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1:200 - 1:400, Immunocytochemistry: 1:75, Immunohistochemistry (Paraffin): Assay-dependent, Western Blot: 1 ug/mL

Aliases :

acetaldehyde dehydrogenase 2; Ahd1; Ahd-1; Ahd5; Ahd-5; AHD-M1; aldehyde dehydrogenase 2 family (mitochondrial); aldehyde dehydrogenase 2, mitochondrial; aldehyde dehydrogenase, mitochondrial; ALDH class 2; ALDH1; ALDH2; ALDH-E2; ALDHI; ALDM; EC 1.2.1.3; liver mitochondrial ALDH; MGC1806; mitochondrial aldehyde dehydrogenase; nucleus-encoded mitochondrial aldehyde dehydrogenase 2