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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
TGF beta-1 Monoclonal Antibody (TB21)
catalog :
MA5-16949
quantity :
100 ug
price :
US 524.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
TB21
reactivity :
human, mouse, rat, domestic sheep, domestic rabbit
application :
western blot, ELISA, immunohistochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, blocking or activating experiments
more info or order :
Invitrogen product webpage
citations: 11
Published Application/Species/Sample/DilutionReference
  • blocking or activating experiments; human
Bourreau E, Ronet C, Couppie P, Sainte Marie D, Tacchini Cottier F, Launois P. IL-10 producing CD8+ T cells in human infection with Leishmania guyanensis. Microbes Infect. 2007;9:1034-41 pubmed
  • blocking or activating experiments; human
Kariminia A, Bourreau E, Pascalis H, Couppie P, Sainte Marie D, Tacchini Cottier F, et al. Transforming growth factor beta 1 production by CD4+ CD25+ regulatory T cells in peripheral blood mononuclear cells from healthy subjects stimulated with Leishmania guyanensis. Infect Immun. 2005;73:5908-14 pubmed
Menzele A, Aboalgasm H, Ballo R, Gwanyanya A. Hyperglycaemia-induced impairment of the autorhythmicity and gap junction activity of mouse embryonic stem cell-derived cardiomyocyte-like cells. Histochem Cell Biol. 2023;159:329-337 pubmed publisher
Lee Y, Heo S, Lee H, Oh S, Kim H, Lim S, et al. Combinatorial prophylactic effect of phlorotannins with photobiomodulation against tracheal stenosis. iScience. 2022;25:105405 pubmed publisher
Karagülle O, Yurttas A. Ozone combined with doxorubicin exerts cytotoxic and anticancer effects on Luminal-A subtype human breast cancer cell line. Rev Assoc Med Bras (1992). 2022;68:507-513 pubmed publisher
Kim B, Kim H, Park J, Cho C, Park S, Lim Y. Restoration of Homeostasis in the Tracheal Mucosa After Thyroid Surgery in a Rat Model. In Vivo. 2022;36:161-169 pubmed publisher
Zheng X, Li L, Yu C, Yang J, Zhao Y, Su C, et al. Establishment of a tumor immune microenvironment-based molecular classification system of breast cancer for immunotherapy. Aging (Albany NY). 2021;13:24313-24338 pubmed publisher
Nishad R, Mukhi D, Singh A, Motrapu M, Chintala K, Tammineni P, et al. Growth hormone induces mitotic catastrophe of glomerular podocytes and contributes to proteinuria. Cell Death Dis. 2021;12:342 pubmed publisher
Jia L, Xue K, Liu J, Habotta O, Hu L, Abdel Moneim A. Anticolitic Effect of Berberine in Rat Experimental Model: Impact of PGE2/p38 MAPK Pathways. Mediators Inflamm. 2020;2020:9419085 pubmed publisher
Roh S, Kim J, Cha H, Lim H, Park Y, Lee K, et al. Molecular Signatures of Sinus Node Dysfunction Induce Structural Remodeling in the Right Atrial Tissue. Mol Cells. 2020;43:408-418 pubmed publisher
Kim M, Kim S, Kim H, Hwang C, Man Choi J, Kang H. Development of a reproducible in vivo laser-induced scar model for wound healing study and management. Biomed Opt Express. 2019;10:1965-1977 pubmed publisher
product information
Product Type :
Antibody
Product Name :
TGF beta-1 Monoclonal Antibody (TB21)
Catalog # :
MA5-16949
Quantity :
100 ug
Price :
US 524.00
Clonality :
Monoclonal
Purity :
Protein G
Host :
Mouse
Reactivity :
Human, Mink, Mouse, Mustelid, Ovine, Rabbit, Rat
Applications :
ELISA: Assay-dependent, Flow Cytometry: Assay-dependent, Immunohistochemistry (Frozen): Assay-dependent, Immunohistochemistry (Paraffin): Assay-dependent, Western Blot: Assay-dependent
Species :
Human, Mink, Mouse, Mustelid, Ovine, Rabbit, Rat
Clone :
TB21
Isotype :
IgG1
Storage :
Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.
Description :
TGF beta-1 (TGFB1, Transforming Growth Factor Beta 1) is a polypeptide member of the transforming growth factor beta superfamily of cytokines, found almost ubiquitously in tissues. Transforming growth factor (TGF)-b is stored in the extracellular matrix as a latent complex with its pro-domain. Activation of TGF beta-1 requires the binding of aV integrin to an RGD sequence in the prodomain and exertion of force on this domain, which is held in the extracellular matrix by latent TGF-b binding proteins. Latent forms are complexes of TGF beta-1, an amino-terminal portion of the TGF-beta precursor, designated TGF-LAP (TGF-latency associated peptide), and a specific binding protein, known as LTBP. TGF beta-1 helps regulates proliferation, differentiation, adhesion, migration in many cell types. Many cells have TGF beta receptors, and the protein positively and negatively regulates many other growth factors. TGF beta-1 is cleaved into a latency-associated peptide and a mature TGF beta-1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGF beta-1 homodimer. The mature peptide may also form heterodimers with other TGF beta family members. The gene for TGF beta-1 is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease and cystic fibrosis.
Immunogen :
Human Transforming Growth Factor Beta 1 from platelets
Format :
Liquid
Applications w/Dilutions :
ELISA: Assay-dependent, Flow Cytometry: Assay-dependent, Immunohistochemistry (Frozen): Assay-dependent, Immunohistochemistry (Paraffin): Assay-dependent, Western Blot: Assay-dependent
Aliases :
CED; cytokine; DPD1; LAP; Latency-associated peptide; prepro-transforming growth factor beta-1; regulatory protein; TGF b; TGF b 1; TGF beta; tgf beta 1; tgf beta1; TGF beta-1; TGF beta-1 protein; TGF ß; TGF ß 1; TGF ß1; Tgfb; TGFB1; TGF-B1; Tgfb-1; TGFbeta; TGF-beta 1; TGF-beta 1 protein; TGFbeta1; TGF-beta1; TGF-beta-1; TGFß1; Transforming growth factor; transforming growth factor b1; transforming growth factor beta; transforming growth factor beta 1; transforming growth factor beta-1; Transforming growth factor beta-1 proprotein; transforming growth factor beta-1 proprotein; transforming growth factor beta-1; transforming growth factor ß1; transforming growth factor, beta 1; transforming growth factor, beta 1 (Camurati-Engelmann disease); transforming growth factor, beta-1; transforming growth factor-beta 1; transforming growth factor-beta I; transforming growth factor-beta-1; transforming growth factor-beta-1 precursor; unnamed protein product
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA