CD206 Monoclonal Antibody (MR5D3), FITC | Invitrogen MA5-16870 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD206 Monoclonal Antibody (MR5D3), FITC

catalog :

MA5-16870

quantity :

100 ug

price :

US 437.00

clonality :

monoclonal

host :

rat

conjugate :

FITC

clone name :

MR5D3

reactivity :

mouse

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 16

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; 1:50; loading ...; fig s2	Okamura T, Hashimoto Y, Mori J, Yamaguchi M, Majima S, Senmaru T, et al. ILC2s Improve Glucose Metabolism Through the Control of Saturated Fatty Acid Absorption Within Visceral Fat. Front Immunol. 2021;12:669629 pubmed publisher
flow cytometry; mouse; 2.5 ug/ml; fig 9	Su S, Zhao Q, He C, Huang D, Liu J, Chen F, et al. miR-142-5p and miR-130a-3p are regulated by IL-4 and IL-13 and control profibrogenic macrophage program. Nat Commun. 2015;6:8523 pubmed publisher
	Chen L, Pan D, Zhang Y, Zhang E, Ma L. C-C Motif Chemokine 2 Regulates Macrophage Polarization and Contributes to Myocardial Infarction Healing. J Interferon Cytokine Res. 2024;44:68-79 pubmed publisher
	Chen Z, Li Y, Yuan Y, Lai K, Ye K, Lin Y, et al. Single-cell sequencing reveals homogeneity and heterogeneity of the cytopathological mechanisms in different etiology-induced AKI. Cell Death Dis. 2023;14:318 pubmed publisher
	Okamura T, Hamaguchi M, Hasegawa Y, Hashimoto Y, Majima S, Senmaru T, et al. Oral Exposure to Polystyrene Microplastics of Mice on a Normal or High-Fat Diet and Intestinal and Metabolic Outcomes. Environ Health Perspect. 2023;131:27006 pubmed publisher
	Chen Y, Lowery A, Lin S, Walker A, Chen K. Tumor cell-derived asymmetric dimethylarginine regulates macrophage functions and polarization. Cancer Cell Int. 2022;22:351 pubmed publisher
	Shi L, Zhang P, Jin R, Chen X, Dong L, Chen W. Dioscin ameliorates inflammatory bowel disease by up-regulating miR-125a-5p to regulate macrophage polarization. J Clin Lab Anal. 2022;36:e24455 pubmed publisher
	Phelps D, Chinchilli V, Yang L, Shearer D, Weisz J, Zhang X, et al. The alveolar macrophage toponome of female SP-A knockout mice differs from that of males before and after SP-A1 rescue. Sci Rep. 2022;12:5039 pubmed publisher
	Liu C, Su B, Chen J. Tilapia Piscidin 4 (TP4) Reprograms M1 Macrophages to M2 Phenotypes in Cell Models of Gardnerella vaginalis-Induced Vaginosis. Front Immunol. 2021;12:773013 pubmed publisher
	Harada T, Tsuboi I, Hino H, Yuda M, Hirabayashi Y, Hirai S, et al. Age-related exacerbation of hematopoietic organ damage induced by systemic hyper-inflammation in senescence-accelerated mice. Sci Rep. 2021;11:23250 pubmed publisher
	Zhu Q, Yuan J, He Y, Hu Y. The Effect of miR-520b on Macrophage Polarization and T Cell Immunity by Targeting PTEN in Breast Cancer. J Oncol. 2021;2021:5170496 pubmed publisher
	Mittal A, Wang M, Vidyarthi A, Yanez D, Pizzurro G, Thakral D, et al. Topical arginase inhibition decreases growth of cutaneous squamous cell carcinoma. Sci Rep. 2021;11:10731 pubmed publisher
	Chen J, He Y, Zhong X, Cai Z, Lyu Y, Zhao Z, et al. Ribonuclease T2 from Aspergillus fumigatus promotes T helper type 2 responses through M2 polarization of macrophages. Int J Mol Med. 2020;46:718-728 pubmed publisher
	Okamura T, Hamaguchi M, Bamba R, Nakajima H, Yoshimura Y, Kimura T, et al. Immune modulating effects of additional supplementation of estradiol combined with testosterone in murine testosterone-deficient NAFLD model. Am J Physiol Gastrointest Liver Physiol. 2020;318:G989-G999 pubmed publisher
	Zhao X, Tang X, Guo N, An Y, Chen X, Shi C, et al. Biochanin a Enhances the Defense Against Salmonella enterica Infection Through AMPK/ULK1/mTOR-Mediated Autophagy and Extracellular Traps and Reversing SPI-1-Dependent Macrophage (MΦ) M2 Polarization. Front Cell Infect Microbiol. 2018;8:318 pubmed publisher
	Yang C, Sun Y, Yu W, Yin X, Weng J, Feng B. Modulation of macrophage phenotype through controlled release of interleukin-4 from gelatine coatings on titanium surfaces. Eur Cell Mater. 2018;36:15-29 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD206 Monoclonal Antibody (MR5D3), FITC

Catalog # :

MA5-16870

Quantity :

100 ug

Price :

US 437.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: Neat

Species :

Mouse

Clone :

MR5D3

Isotype :

IgG2a

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles. Store in the dark.

Description :

CD206 (MSR, Mannose receptor, MRC1) is a 175 kDa transmembrane protein belonging to the group of pattern recognition receptors. CD206 is predominantly expressed in tissue macrophages, dendritic cells, a subpopulation of endothelial cells and sperm cells. CD206 is thought to play a role in the innate and adaptive immune response. CD206 is also expressed on microglia and mato cells of the brain but not astrocytes or neurons. CD206 also mediate the recognition and uptake of a variety of macromolecules, including modified lipoproteins, advanced glycation end (AGEs) products and amyloid b-protein (Abeta). While the normal role of CD206 is associated with cell adhesion and host defense mechanisms, it also has been implicated in the development of atherosclerosis and Amyloid beta deposition in Alzheimer's disease (AD). CD206’s gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. CD206 has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. Other diseases associated with CD206 dysfunction include leprosy and Gaucher’s Disease.

Immunogen :

Chimaeric CRD4-7-Fc protein.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Neat

Aliases :

AW259686; bA541I19.1; CD206; CELE_Y39A3CR.4; CLEC13D; CLEC13DL; C-type lectin domain family 13 member D; C-type lectin domain family 13 member D-like; ddp-1; hMR; Human mannose receptor; macrophage mannose receptor 1; Macrophage mannose receptor 1-like protein 1; mannose receptor, C type 1; mannose receptor, C type 1-like 1; Mitochondrial import inner membrane translocase subunit Tim8; MMR; MR; MRC1; MRC1L1; tim-8; Y39A3CR.4

more info or order :

Invitrogen product webpage