IL-10 Monoclonal Antibody (JES3-9D7) | Invitrogen MA5-16749 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IL-10 Monoclonal Antibody (JES3-9D7)

catalog :

MA5-16749

quantity :

500 ug

price :

US 582.00

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

JES3-9D7

reactivity :

African green monkey, human, rhesus macaque

application :

western blot, ELISA, flow cytometry

more info or order :

Invitrogen product webpage

citations: 17

Published Application/Species/Sample/Dilution	Reference
ELISA; human; loading ...; fig 5c	Otsuka Y, Watanabe E, Shinya E, Okura S, Saeki H, Geijtenbeek T, et al. Differentiation of Langerhans Cells from Monocytes and Their Specific Function in Inducing IL-22-Specific Th Cells. J Immunol. 2018;201:3006-3016 pubmed publisher
flow cytometry; human; loading ...; fig 3b	Pizzolla A, Nguyen T, Sant S, Jaffar J, Loudovaris T, Mannering S, et al. Influenza-specific lung-resident memory T cells are proliferative and polyfunctional and maintain diverse TCR profiles. J Clin Invest. 2018;128:721-733 pubmed publisher
flow cytometry; human; loading ...; tbl 1	Sumatoh H, Teng K, Cheng Y, Newell E. Optimization of mass cytometry sample cryopreservation after staining. Cytometry A. 2017;91:48-61 pubmed publisher
flow cytometry; rhesus macaque; fig 6f flow cytometry; human; fig 1e	Miles B, Miller S, Folkvord J, Levy D, Rakasz E, Skinner P, et al. Follicular Regulatory CD8 T Cells Impair the Germinal Center Response in SIV and Ex Vivo HIV Infection. PLoS Pathog. 2016;12:e1005924 pubmed publisher
flow cytometry; human; loading ...; fig 6c	Neumann L, Mueller M, Moos V, Heller F, Meyer T, Loddenkemper C, et al. Mucosal Inducible NO Synthase-Producing IgA+ Plasma Cells in Helicobacter pylori-Infected Patients. J Immunol. 2016;197:1801-8 pubmed publisher
flow cytometry; human; loading ...; fig s1	Chu H, Khosravi A, Kusumawardhani I, Kwon A, Vasconcelos A, Cunha L, et al. Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease. Science. 2016;352:1116-20 pubmed publisher
flow cytometry; African green monkey; loading ...; fig 5a	Phuah J, Wong E, Gideon H, Maiello P, Coleman M, Hendricks M, et al. Effects of B Cell Depletion on Early Mycobacterium tuberculosis Infection in Cynomolgus Macaques. Infect Immun. 2016;84:1301-1311 pubmed publisher
flow cytometry; African green monkey; fig 3	de Campos S, Souza Lemos C, Teva A, Porrozzi R, Grimaldi G. Systemic and compartmentalised immune responses in a Leishmania braziliensis-macaque model of self-healing cutaneous leishmaniasis. Vet Immunol Immunopathol. 2010;137:149-54 pubmed publisher
flow cytometry; human; fig 3	Della Bella S, Giannelli S, Taddeo A, Presicce P, Villa M. Application of six-color flow cytometry for the assessment of dendritic cell responses in whole blood assays. J Immunol Methods. 2008;339:153-64 pubmed publisher
ELISA; human; fig 4	Prehn J, Landers C, Targan S. A soluble factor produced by lamina propria mononuclear cells is required for TNF-alpha enhancement of IFN-gamma production by T cells. J Immunol. 1999;163:4277-83 pubmed
	Chen D, Xie J, Fiskesund R, Dong W, Liang X, Lv J, et al. Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype. Nat Commun. 2018;9:873 pubmed publisher
	Roux C, Saviane G, Pini J, Belaïd N, Dhib G, Voha C, et al. Immunosuppressive Mesenchymal Stromal Cells Derived from Human-Induced Pluripotent Stem Cells Induce Human Regulatory T Cells In Vitro and In Vivo. Front Immunol. 2017;8:1991 pubmed publisher
	Vargas Hernandez A, Mace E, Zimmerman O, Zerbe C, Freeman A, Rosenzweig S, et al. Ruxolitinib partially reverses functional natural killer cell deficiency in patients with signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations. J Allergy Clin Immunol. 2018;141:2142-2155.e5 pubmed publisher
	Powell R, Lissauer D, Tamblyn J, Beggs A, Cox P, Moss P, et al. Decidual T Cells Exhibit a Highly Differentiated Phenotype and Demonstrate Potential Fetal Specificity and a Strong Transcriptional Response to IFN. J Immunol. 2017;199:3406-3417 pubmed publisher
	Schwerd T, Twigg S, Aschenbrenner D, Manrique S, Miller K, Taylor I, et al. A biallelic mutation in IL6ST encoding the GP130 co-receptor causes immunodeficiency and craniosynostosis. J Exp Med. 2017;214:2547-2562 pubmed publisher
	Sulzer D, Alcalay R, Garretti F, Cote L, Kanter E, Agin Liebes J, et al. T cells from patients with Parkinson's disease recognize α-synuclein peptides. Nature. 2017;546:656-661 pubmed publisher
	Reignat S, Webster G, Brown D, Ogg G, King A, Seneviratne S, et al. Escaping high viral load exhaustion: CD8 cells with altered tetramer binding in chronic hepatitis B virus infection. J Exp Med. 2002;195:1089-101 pubmed

product information

Product Type :

Antibody

Product Name :

IL-10 Monoclonal Antibody (JES3-9D7)

Catalog # :

MA5-16749

Quantity :

500 ug

Price :

US 582.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Rat

Reactivity :

Human

Applications :

ELISA: Assay-dependent, Flow Cytometry: 1:10-1:50, Functional Assay: Assay-dependent, Western Blot: 1:100

Species :

Human

Clone :

JES3-9D7

Isotype :

IgG1

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

IL-10 encodes a protein that acts as a cytokine and is primarily produced by monocytes, with some production by lymphocytes. This cytokine has various effects on immunoregulation and inflammation, including down-regulating the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. Additionally, IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice have suggested that this cytokine is an essential immunoregulator in the intestinal tract. Mutations in this gene have been associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. Diseases associated with IL10 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1.

Immunogen :

Recombinant human IL-10

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Flow Cytometry: 1:10-1:50, Functional Assay: Assay-dependent, Western Blot: 1:100

Aliases :

CSIF; cytokine; Cytokine synthesis inhibitory factor; GVHDS; H-IL-10; il 10; IL10; IL-10; IL-10 precursor; IL10A; IL10X; ILN; Interleukin; interleukin 10; Interleukin10; interleukin-10; MGC126450; MGC126451; RP11-262N9.1; T-cell growth inhibitory factor; TGIF

more info or order :

Invitrogen product webpage