This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
PMEL Monoclonal Antibody (HMB-45)
catalog :
MA5-16712
quantity :
1 mL
price :
US 910.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
HMB-45
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
citations: 23
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - frozen section; human; 1:150; loading ...; fig 1d
Osterburg A, Nelson R, Yaniv B, Foot R, Donica W, Nashu M, et al. NK cell activating receptor ligand expression in lymphangioleiomyomatosis is associated with lung function decline. JCI Insight. 2016;1:e87270 pubmed publisher
  • immunocytochemistry; mouse; fig 3o
Dennis M, Delevoye C, Acosta Ruiz A, Hurbain I, Romao M, Hesketh G, et al. BLOC-1 and BLOC-3 regulate VAMP7 cycling to and from melanosomes via distinct tubular transport carriers. J Cell Biol. 2016;214:293-308 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100
Di Marco M, Grassi E, Vecchiarelli S, Durante S, Macchini M, Biasco G. Retroperitoneal lymphangioma: A report of 2 cases and a review of the literature regarding the differential diagnoses of retroperitoneal cystic masses. Oncol Lett. 2016;11:3161-3166 pubmed
  • flow cytometry; mouse; fig s1
Dennis M, Mantegazza A, Snir O, Tenza D, Acosta Ruiz A, Delevoye C, et al. BLOC-2 targets recycling endosomal tubules to melanosomes for cargo delivery. J Cell Biol. 2015;209:563-77 pubmed publisher
  • immunohistochemistry; human
Jabbour M, Seoud M, Al Ahmadie H, Abdul Karim F, Zaatari G. ASPL-TFE3 translocation in vulvovaginal alveolar soft part sarcoma. Int J Gynecol Pathol. 2014;33:263-7 pubmed publisher
  • immunocytochemistry; human
  • western blot; human
Theos A, WATT B, Harper D, Janczura K, Theos S, Herman K, et al. The PKD domain distinguishes the trafficking and amyloidogenic properties of the pigment cell protein PMEL and its homologue GPNMB. Pigment Cell Melanoma Res. 2013;26:470-86 pubmed publisher
  • immunocytochemistry; human; 1:50
  • western blot; human
Leonhardt R, Vigneron N, Hee J, Graham M, Cresswell P. Critical residues in the PMEL/Pmel17 N-terminus direct the hierarchical assembly of melanosomal fibrils. Mol Biol Cell. 2013;24:964-81 pubmed publisher
  • immunohistochemistry; human; 1:100
Kim B, Bae Y, Kim S, Jeong H, Hong S, Yoon S. Usefulness of Ki-67 (MIB-1) immunostaining in the diagnosis of pulmonary sclerosing hemangiomas. APMIS. 2013;121:105-10 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:40
Niu H, Wang F, Zhang P, Bing Z. Cardiac Epithelioid PEComa: Report of Two Cases and Review of the Literature. Case Rep Med. 2012;2012:521678 pubmed publisher
  • immunohistochemistry; human; 1:40
Wang Z, Gong Q, Fan Q. Expression of E-cadherin in angiomyolipoma. Hum Pathol. 2012;43:2348-53 pubmed publisher
  • immunohistochemistry; human
Zhou Z, Yu M, Yang S, Zhou J, Sun R, Yang G. Dural angioleiomyoma of the middle cranial fossa: a case report and review of the literature. Brain Tumor Pathol. 2013;30:117-21 pubmed publisher
  • immunohistochemistry; human; 1:40
Clayton E, Furth E, Ziober A, Xu T, Yao Y, Hwang P, et al. A case of primary clear cell hepatocellular carcinoma in a non-cirrhotic liver: an immunohistochemical and ultrastructural study. Rare Tumors. 2012;4:e29 pubmed publisher
  • immunohistochemistry; mouse; 1:1000
Hooijkaas A, Gadiot J, van der Valk M, Mooi W, Blank C. Targeting BRAFV600E in an inducible murine model of melanoma. Am J Pathol. 2012;181:785-94 pubmed publisher
  • immunocytochemistry; mouse
Sitaram A, Dennis M, Chaudhuri R, De Jesus Rojas W, Tenza D, Setty S, et al. Differential recognition of a dileucine-based sorting signal by AP-1 and AP-3 reveals a requirement for both BLOC-1 and AP-3 in delivery of OCA2 to melanosomes. Mol Biol Cell. 2012;23:3178-92 pubmed
  • immunohistochemistry; human; 1:50
Yin W, Li J, Chan J. Sporadic haemangioblastoma of the kidney with rhabdoid features and focal CD10 expression: report of a case and literature review. Diagn Pathol. 2012;7:39 pubmed publisher
  • immunohistochemistry; human
Anbar T, El Sawy A, Attia S, Barakat M, Moftah N, El Ammawy T, et al. Effect of PUVA therapy on melanocytes and keratinocytes in non-segmental vitiligo: histopathological, immuno-histochemical and ultrastructural study. Photodermatol Photoimmunol Photomed. 2012;28:17-25 pubmed publisher
  • immunohistochemistry; human; 1:100
Jabbour M, Fedda F, Tawil A, Shabb N, Boulos F. Follicular dendritic cell sarcoma of the head and neck expressing thyroid transcription factor-1: a case report with clinicopathologic and immunohistochemical literature review. Appl Immunohistochem Mol Morphol. 2014;22:705-12 pubmed publisher
  • immunocytochemistry; human; fig 3
  • western blot; human; fig 1
Leonhardt R, Vigneron N, Rahner C, Cresswell P. Proprotein convertases process Pmel17 during secretion. J Biol Chem. 2011;286:9321-37 pubmed publisher
  • immunocytochemistry; mouse
Setty S, Tenza D, Truschel S, Chou E, Sviderskaya E, Theos A, et al. BLOC-1 is required for cargo-specific sorting from vacuolar early endosomes toward lysosome-related organelles. Mol Biol Cell. 2007;18:768-80 pubmed
Li Z, Wang C, Deng H, Wu J, Huang H, Sun R, et al. Robust Photodynamic Therapy Using 5-ALA-Incorporated Nanocomplexes Cures Metastatic Melanoma through Priming of CD4+CD8+ Double Positive T Cells. Adv Sci (Weinh). 2019;6:1802057 pubmed publisher
Ozaki Y, Shindoh J, Miura Y, Nakajima H, Oki R, Uchiyama M, et al. Serial pseudoprogression of metastatic malignant melanoma in a patient treated with nivolumab: a case report. BMC Cancer. 2017;17:778 pubmed publisher
Yu W, Wang Y, Jiang Y, Zhang W, Li Y. Distinct immunophenotypes and prognostic factors in renal cell carcinoma with sarcomatoid differentiation: a systematic study of 19 immunohistochemical markers in 42 cases. BMC Cancer. 2017;17:293 pubmed publisher
Berson J, Theos A, Harper D, Tenza D, Raposo G, Marks M. Proprotein convertase cleavage liberates a fibrillogenic fragment of a resident glycoprotein to initiate melanosome biogenesis. J Cell Biol. 2003;161:521-33 pubmed
product information
Product Type :
Antibody
Product Name :
PMEL Monoclonal Antibody (HMB-45)
Catalog # :
MA5-16712
Quantity :
1 mL
Price :
US 910.00
Clonality :
Monoclonal
Purity :
purified
Host :
Mouse
Reactivity :
Human
Applications :
Immunohistochemistry (Frozen): 1:40, Immunohistochemistry (Paraffin): 1:40
Species :
Human
Clone :
HMB-45
Isotype :
IgG1
Storage :
4°C or -20°C if preferred
Description :
Melanoma is a malignant tumor of melanocytes which are found predominantly in skin but also in the bowel and the eye (see uveal melanoma). It is one of the rarer types of skin cancer but causes the majority of skin cancer related deaths.
Immunogen :
Extract of pigmented melanoma metastases from lymph nodes.
Format :
Liquid
Applications w/Dilutions :
Immunohistochemistry (Frozen): 1:40, Immunohistochemistry (Paraffin): 1:40
Aliases :
95 kDa melanocyte-specific secreted glycoprotein; 95kDa melanocyte-specific secreted glycoprotein; D10H12S53E; D12S53E; D12S53Eh; gp100; gp87; M-alpha; M-beta; ME20; ME20M; ME20-M; ME20-S; Melanocyte lineage specific antigen GP100; melanocyte protein mel 17; melanocyte protein PMEL; Melanocyte protein Pmel 17; melanocytes lineage-specific antigen GP100; Melanoma-associated ME20 antigen; melanosomal matrix protein17; P1; P100; P26; PMEL; Pmel 17; PMEL17; premelanosome protein; Secreted melanoma-associated ME20 antigen; SI; SIL; SILV; silver homolog; silver locus protein; silver locus protein homolog; silver, mouse, homolog of
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA