TLR1 Monoclonal Antibody (GD2.F4) | Invitrogen MA5-16691 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TLR1 Monoclonal Antibody (GD2.F4)

catalog :

MA5-16691

quantity :

200 ug

price :

US 700.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

GD2.F4

reactivity :

human

application :

flow cytometry

citations: 3

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; loading ...; fig 4a	Steiner M, Hawranek T, Schneider M, Ferreira F, Horejs Hoeck J, Harrer A, et al. Elevated Toll-Like Receptor-Induced CXCL8 Secretion in Human Blood Basophils from Allergic Donors Is Independent of Toll-Like Receptor Expression Levels. PLoS ONE. 2016;11:e0149275 pubmed publisher
	Hart B, Tapping R. Differential trafficking of TLR1 I602S underlies host protection against pathogenic mycobacteria. J Immunol. 2012;189:5347-55 pubmed publisher
	Sandor F, Latz E, Re F, Mandell L, Repik G, Golenbock D, et al. Importance of extra- and intracellular domains of TLR1 and TLR2 in NFkappa B signaling. J Cell Biol. 2003;162:1099-110 pubmed

product information

Product Type :

Antibody

Product Name :

TLR1 Monoclonal Antibody (GD2.F4)

Catalog # :

MA5-16691

Quantity :

200 ug

Price :

US 700.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: Assay Dependent

Species :

Human

Clone :

GD2.F4

Isotype :

IgG1

Storage :

4°C or -20°C if preferred

Description :

TLR1 protein is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. The Toll-like receptor (TLR) family in mammals are comprised of a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and an IL-1 receptor motif in the cytoplasmic domain. The TLRs could constitute an important and unrecognized component of innate immunity in humans. In mice, TLR1 interacts with TLR2 and co-expression of TLR1 and TLR2 enhance the NF-kappaB activation in response to a synthetic lipopeptide. They recognize the lipid configuration of the native mycobacterial lipoprotein as well as several tri-acylated lipopeptides. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for the TLR1 gene.

Immunogen :

CD281 (TLR1) Fc fusion protein.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay Dependent

Aliases :

Toll-like Receptor 1, TIL, TIL. LPRS5, rsc786, toll/interleukin-1 receptor-like protein