P-Selectin Monoclonal Antibody (AK-6) | Invitrogen MA5-16567 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

P-Selectin Monoclonal Antibody (AK-6)

catalog :

MA5-16567

quantity :

200 ug

price :

US 518.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

AK-6

reactivity :

human, rhesus macaque

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 2

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; loading ...; fig 6	Wang J, Xiong G, Luo B, Choo C, Yuan S, Tan N, et al. Surface modification of PVDF using non-mammalian sources of collagen for enhancement of endothelial cell functionality. J Mater Sci Mater Med. 2016;27:45 pubmed publisher
	Granai M, Warm V, Vogelsberg A, Milla J, GREIF K, Vogel U, et al. Impact of P-selectin-PSGL-1 Axis on Platelet-Endothelium-Leukocyte Interactions in Fatal COVID-19. Lab Invest. 2023;103:100179 pubmed publisher

product information

Product Type :

Antibody

Product Name :

P-Selectin Monoclonal Antibody (AK-6)

Catalog # :

MA5-16567

Quantity :

200 ug

Price :

US 518.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human, Rhesus Monkey

Applications :

Flow Cytometry: 1:10-1:100, Immunocytochemistry: Assay-dependent, Immunohistochemistry (Frozen): 1:1,000-1:5,000, Immunohistochemistry (Paraffin): 1:500-1:2,000, Western Blot: Assay-dependent

Species :

Human, Rhesus Monkey

Clone :

AK-6

Isotype :

IgG1

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

P-selectin (Selectin P, GMP-140, LECAM3, CD62 antigen-like family member) is a 140 kDa type 1 transmembrane glycoprotein, and is one of the most commonly studied proteins that regulate cell rolling. P-selectin is stored in the Weibel-Palade bodies of endothelial cells, as well as in a-granules of platelets. From there, it can be rapidly brought to the cell surface after exposure to thrombin, histamine, complement 5a, Ca21 ionophores, or adenosine diphosphate. P-selectin protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. P-selectin plays an important role in adhesive processes between leucocytes and endothelial cells, and is a calcium dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens found on neutrophils and monocytes. P-selectin is constitutively expressed in inflammation and contributes to atherogenesis, thrombosis and tissue destruction. Clinically, P-selectin is used to distinguish heparin induced thrombocytopenia with and without thrombosis.

Immunogen :

Human platelet membrane glycoproteins

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1:10-1:100, Immunocytochemistry: Assay-dependent, Immunohistochemistry (Frozen): 1:1,000-1:5,000, Immunohistochemistry (Paraffin): 1:500-1:2,000, Western Blot: Assay-dependent

Aliases :

CD62; CD62 antigen-like family member P; CD62P; CD62P antigen; CD62P; CD62 homolog; FLJ45155; GMP140; GMP-140; GMRP; Granule membrane protein 140; granule membrane protein 140kDa; granulocyte membrane protein; Grmp; LECAM3; leukocyte-endothelial cell adhesion molecule 3; PADGEM; Platelet activation dependent granule-external membrane protein; platelet alpha-granule membrane protein; PSEL; PSELECT; P-selectin; P-selectin precursor; RP1-86F14.2; selectin P; selectin P (granule membrane protein 140kDa, antigen CD62); selectin, platelet; Selp

more info or order :

Invitrogen product webpage